CdSe nanocrystals (NCs) have great application prospects in various fields due to their novel properties. Some high-cost and toxic materials such as --octylphosphine oxide (TOPO) are used in the popular method to synthesize CdSe NCs. Based on this, a new low-cost, environment-friendly and safe solvent was introduced in the synthesis of CdSe NCs in this paper. The prepared CdSe NCs were characterized by ultraviolet-visible spectra (UV-Vis), photoluminescence (PL), transmission electron micrograph (TEM), energy disperse X-ray spectra (EDX) and X-ray diffraction (XRD). The CdSe NCs obtained which show a good PL property are monodisperse, size-tunable and of high crystallinity. It indicates that the new solvent A is a good substitute for the solvent used in the classic route and achieves a greener synthesis of CdSe NCs.