Isolation of microbe for asymmetric reduction of prochiral aromatic ketone and its reaction characters

2007, Volume 1, Issue 4

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Frontiers of Chemical Science and Engineering >> 2007, Volume 1, Issue 4 doi: 10.1007/s11705-007-0076-7

Isolation of microbe for asymmetric reduction of prochiral aromatic ketone and its reaction characters

1.College of Chemical Engineering and Technology, Wuhan University of Science and Technology, Wuhan 430081, China; 2.College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China; 3.Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou 310027, China

Available online: 2007-12-05

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Abstract

The favorable microbes for the asymmetric reduction of prochiral aromatic ketones was isolated from soil using acetophenone as the sole carbon source, when the asymmetric reduction of acetophenone (ACP) to chiral ?-phenethyl alcohol (PEA) was chosen as the model reaction. Two microbe strains with excellent catalytic activity were obtained. They were and identified by bacteria identification. The product of the asymmetric reduction of ACP catalyzed by was mainly R-PEA and that by was mainly S-PEA. The yield and enantiomeric excesses (e.e.) could respectively reach 75% and 90% for , and 80% and 70% for , much higher than those catalyzed by baker s yeast.

Keywords

excellent catalytic ; prochiral aromatic ; enantiomeric ; -phenethyl ; catalytic activity

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