Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

2009, Volume 3, Issue 3

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Frontiers of Chemical Science and Engineering >> 2009, Volume 3, Issue 3 doi: 10.1007/s11705-009-0021-z

Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; 2. Schools of Life Science and Environmental Science, Shanghai Normal University, Shanghai 200234, China; 3. Institute of Green Chemistry and Fine Chemicals, Beijing University of Technology, Beijing 100022, China

Available online: 2009-09-05

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Abstract

A series of new benzimidazole derivatives were designed and synthesized. Their chemical structures were testified by H NMR, infrared spectroscopy (IR), mass spectrography (MS), and elemental analysis. Their potent antiviral properties indicated the prospect of new drugs. Compound , , , , , , and were identified as novel antivirus with much better selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B in VERO cells.

Keywords

benzimidazole ; coxsackie virus B₃ ; antiviral properties

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