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2009, Volume 3, Issue 2

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Frontiers of Chemical Science and Engineering >> 2009, Volume 3, Issue 2 doi: 10.1007/s11705-009-0051-6

β-Cyclodextrin promoted oxidation of primary amines to nitriles in water

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China

Available online: 2009-06-05
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Abstract

A facile, efficient and substrate-selective oxidation of the primary amines with NaClO as oxidant catalyzed by cyclodextrin ( CD) has been developed in water for the first time, and the behavior of cyclodextrin that catalyzed the primary amines to nitriles in water was investigated. It was found that the primary amines which could form host-guest complexes with cyclodextrin were oxidized to nitriles with excellent yields at ambient temperature. The results show that cyclodextrin worked not only as a solubilizing agent but also as a catalyst in these reactions.

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