Frontiers of Chemical Science and Engineering
>> 2011,
Volume 5,
Issue 1
doi:
10.1007/s11705-010-0537-2
RESEARCH ARTICLE
Synthesis and characterization of norfloxacin biomonomer
1. Department of Chemistry and Environmental Science, Ningde normal University, Ningde 352100, China; 2. College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China; 3. Fujian Provincial Key Laboratory of Polymer Materials, Fuzhou University, Fuzhou 350108, China
Available online: 2011-03-05
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Abstract
A novel drug agent named norfloxacin biomonomer was developed in order to solve the problem of low drug content, uneven drug distribution, low molecular weight, and wide molecular weight distribution of polymer drug, based on polyurethane, which was used as an antibacterial agent to control the bacterial infection associated with biofilm formation on polymeric materials used in biologic environments. In this research, norfloxacin biomonomer was synthesized by esterifying the compound of norfloxacin. High-performance liquid chromatography system was used to analyze the purity of the final product and intermediate products, and Fourier transform infrared spectrometer and mass spectrum were used to verify the final product and intermediate products. The results showed that the objective product was developed successfully. The final product of norfloxacin biomonomer could be incorporated into the polyurethane as chain extender.
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