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Frontiers of Chemical Science and Engineering >> 2014, Volume 8, Issue 1 doi: 10.1007/s11705-014-1412-3

Materials and surface engineering to control bacterial adhesion and biofilm formation: A review of recent advances

1. Department of Biomedical and Chemical Engineering, Syracuse Biomaterials Institute, Syracuse University, Syracuse, NY 13244, USA; 2. Department of Civil and Environmental Engineering, Department of Biology, Syracuse University, Syracuse, NY 13244, USA

Available online: 2014-03-05

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Abstract

Bacterial adhesion to surfaces and subsequent biofilm formation are a leading cause of chronic infections and biofouling. These processes are highly sensitive to environmental factors and present a challenge to research using traditional approaches with uncontrolled surfaces. Recent advances in materials research and surface engineering have brought exciting opportunities to pattern bacterial cell clusters and to obtain synthetic biofilms with well-controlled cell density and morphology of cell clusters. In this article, we will review the recent achievements in this field and comment on the future directions.

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