Frontiers of Chemical Science and Engineering
>> 2014,
Volume 8,
Issue 4
doi:
10.1007/s11705-014-1452-8
RESEARCH ARTICLE
Controlled drug release of 5-amino salicylic acid by poly(2-hydroxyethylmethacrylate) grafted agar
Department of Chemistry, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India
Accepted: 2014-12-11
Available online: 2015-01-14
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Abstract
The utilization of poly (2-hydroxyethylmethacrylate) grafted agar (Ag-g-P(HEMA)) as a matrix for the controlled release of 5-aminosalicylic acid was investigated. Grafted copolymers of 2-hydroxyethylmethacrylate (HEMA) monomers on agar were synthesized by microwave assisted method. drug release studies were performed at pH values of 2 and 7 in order to investigate the possibility of pH triggered release for colon targeted drug delivery. Further, the percent grafting . (the time taken for release of 50% of the enclosed drug) value was studied and the results indicate that it may be possible to develop a programmable drug release matrix based on grafted polysaccharide. Ag-g-P(HEMA) appears to be a useful matrix for controlled release.
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