Designer enzyme for green materials innovation: Lactate-polymerizing enzyme as a key catalyst

2017, Volume 11, Issue 1

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Frontiers of Chemical Science and Engineering >> 2017, Volume 11, Issue 1 doi: 10.1007/s11705-017-1636-0

Designer enzyme for green materials innovation: Lactate-polymerizing enzyme as a key catalyst

. Graduate School of Engineering, Hokkaido University, Hokkaido 060-0808, Japan.. JST, CREST, 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan

Available online: 2017-03-17

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Abstract

Establishment of the regeneratable whole-cell catalyst platform for the?production of biobased polymeric materials is a?typical topic of synthetic biology. In this commentary, discovery story of a “lactate-polymerizing enzyme” (LPE)?and LPE-based?achievements for creating a new variety of polyesters with incorporated unnatural monomers are presented. Besides the importance of microbial platform itself is discussed referring to the “ballooning”- .

Keywords

synthetic biology ; enzyme evolutionary engineering ; polyhydroxyalkanoate

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