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2018, Volume 12, Issue 1

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Frontiers of Chemical Science and Engineering >> 2018, Volume 12, Issue 1 doi: 10.1007/s11705-017-1678-3

Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer

. Department of Chemical Engineering, Nagoya University, Nagoya 464-8603, Japan.. Department of Chemical Engineering and Food Technology, Institute of Technology of Cambodia, Phnom Penh, Cambodia.. Department of Materials Process Engineering, Nagoya University, Nagoya 464-8603, Japan.. Research Institute for Chemical Engineering Process Technology, National Institute of Advanced Industrial Science and Technology, Sendai 983-8551, Japan

Accepted: 2017-11-03 Available online: 2018-02-26
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Abstract

Curcumin is a hydrophobic polyphenol compound exhibiting a wide range of biological activities such as anti-inflammatory, anti-bacterial, anti-fungal, anti-carcinogenic, anti-human immunodeficiency virus, and anti-microbial activity. In this work, a swirl mixer was employed to produce the micronized curcumin with polyvinylpyrrolidone (PVP) by the supercritical anti-solvent process to improve the bioavailability of curcumin. The effects of operating parameters such as curcumin/PVP ratio, feed concentration, temperature, pressure, and CO flow rate were investigated. The characterization and solubility of particles were determined by using scanning electron microscopy, Fourier Transform Infrared spectroscopy, and ultra-violet-visible spectroscopy. The result shows that the optimal condition for the production of curcumin/PVP particles is at curcumin/PVP ratio of 1:30, feed concentration of 5 mg·mL , temperature of 40 °C, pressure of 15 MPa, and CO flow rate of 15 mL·min . Moreover, the dissolution of curcumin/PVP particles is faster than that of raw curcumin.

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