Enhanced penetration strategies for transdermal delivery

2020, Volume 14, Issue 3

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Frontiers of Chemical Science and Engineering >> 2020, Volume 14, Issue 3 doi: 10.1007/s11705-019-1913-1

Enhanced penetration strategies for transdermal delivery

. Pharmacology, Department of Basic Medical Sciences, Faculty of Medical Science, Jinan University, Guangzhou 510632, China.. Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou 510060, China.. Department of Orthopaedics, First Affiliated Hospital of Jinan University, Guangzhou 510632, China

Accepted: 2020-03-06 Available online: 2020-03-06

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Abstract

Transdermal delivery offers several advantages in drug distribution, including convenience, painless administration, avoidance of first-pass metabolism, and ease of termination. However, the natural protective barriers of the skin, such as the stratum corneum, the topmost layer of skin, limit the systemic absorption of external therapeutics via transdermal delivery. Therefore, extensive application of transdermal delivery in medical treatment has been limited. Over the past few years, many formulation strategies and physical technologies, therefore, have been developed to enhance transdermal delivery. This review summarizes various formulation strategies proposed for transdermal delivery and their application in medical treatment.

Keywords

transdermal delivery ; stratum corneum ; enhanced penetration ; therapeutics

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