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2022, Volume 16, Issue 1

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Frontiers of Chemical Science and Engineering >> 2022, Volume 16, Issue 1 doi: 10.1007/s11705-021-2075-5

Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging

Available online：2021-09-09
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Abstract

The design of three novel fatty nitrogen mustard-based anticancer agents with fluorophores incorporated into the alkene structure (CXL 118, CXL121, and CXL122) is described in this report. The results indicated that these compounds are selectively located in lysosomes and exhibit effective antitumour activity. Notably, these compounds can directly serve as both reporting and imaging agents in vitro and in vivo without the need to add other fluorescent tagging agents.

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