Hydroxyl radical-involved cancer therapy via Fenton reactions

2022, Volume 16, Issue 3

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Frontiers of Chemical Science and Engineering >> 2022, Volume 16, Issue 3 doi: 10.1007/s11705-021-2077-3

Hydroxyl radical-involved cancer therapy via Fenton reactions

Available online: 2021-09-09

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Abstract

The tumor microenvironment features over-expressed hydrogen peroxide (H₂O₂). Thus, versatile therapeutic strategies based on H₂O₂ as a reaction substrate to generate hydroxyl radical (•OH) have been used as a prospective therapeutic method to boost anticancer efficiency. However, the limited Fenton catalysts and insufficient endogenous H₂O₂ content in tumor sites greatly hinder •OH production, failing to achieve the desired therapeutic effect. Therefore, supplying Fenton catalysts and elevating H₂O₂ levels into cancer cells are effective strategies to improve •OH generation. These therapeutic strategies are systematically discussed in this review. Furthermore, the challenges and future developments of hydroxyl radical-involved cancer therapy are discussed to improve therapeutic efficacy.

Keywords

hydroxyl radical ; Fenton catalyst ; hydrogen peroxide ; cancer therapy

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