Frontiers of Environmental Science & Engineering >> 2019, Volume 13, Issue 4 doi: 10.1007/s11783-019-1143-2
Ozonation of the 5-fluorouracil anticancer drug and its prodrug capecitabine: Reaction kinetics, oxidation mechanisms, and residual toxicity
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Abstract
Specific second-order rate constants were determined for 5-FU and CAP with ozone. Reaction sites were confirmed by kinetics, Fukui analysis, and products. The olefin moiety was the main ozone reaction site for 5-FU and CAP. Carboxylic acids comprised most of the residual TOC for 5-FU. Ozonation removed the toxicity associated with 5-FU and products but not CAP.
Keywords
Ozone ; 5-fluorouracil ; Capecitabine ; Hydroxyl radicals ; Chemotherapy agents ; Toxicity