Journal Home Online First Current Issue Archive For Authors Journal Information 中文版

Engineering >> 2021, Volume 7, Issue 7 doi: 10.1016/j.eng.2020.02.013

Design, Characterization, and 3D Printing of Cardiovascular Stents with Zero Poisson’s Ratio in Longitudinal Deformation

a Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China
b Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Beijing 100084, China
c “Biomanufacturing and Engineering Living Systems” Innovation International Talents Base (111 Base), Beijing 100084, China
d Department of Mechanical Engineering, Drexel University, Philadelphia, PA 19104, USA

Received: 2019-07-30 Revised: 2020-01-13 Accepted: 2020-02-13 Available online: 2020-07-24

Next Previous

Abstract

Inherent drawbacks associated with drug-eluting stents have prompted the development of bioresorbable cardiovascular stents. Additive manufacturing (3-dimentional (3D) printing) has been widely applied in medical devices. In this study, we develop a novel screw extrusion-based 3D printing system with a new designed mini-screw extruder to fabricate stents. A stent with a zero Poisson’s ratio (ZPR) structure is designed, and a preliminary monofilament test is conducted to investigate appropriate fabrication parameters. 3D-printed stents with different geometric structures are fabricated and analyzed by observation of the surface morphology. An evaluation of the mechanical properties and a preliminary biological evaluation of 3D-printed stents with different parameters are carried out. In conclusion, the screw extrusion-based 3D printing system shows potential for customizable stent fabrication.

Figures

Fig. 1

Fig. 2

Fig. 3

Fig. 4

Fig. 5

Fig. 6

Fig. 7

Fig. 8

Fig. 9

Fig. 10

Fig. 11

References

[ 1 ] Stettler C, Wandel S, Allemann S, Kastrati A, Morice MC, Schömig A, et al. Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysis. Lancet 2007;370:937–48. link1

[ 2 ] Zhang Y, Bourantas CV, Farooq V, Muramatsu T, Diletti R, Onuma Y, et al. Bioresorbable scaffolds in the treatment of coronary artery disease. Med Devices Evid Res 2013;6:37–48. link1

[ 3 ] Wiebe J, Nef HM, Hamm CW. Current status of bioresorbable scaffolds in the treatment of coronary artery disease. J Am Coll Cardiol 2014;64:2541–51. link1

[ 4 ] Ang HY, Bulluck H, Wong P, Venkatraman SS, Huang Y, Foin N. Bioresorbable stents: current and upcoming bioresorbable technologies. Int J Cardiol 2017;228:931–9. link1

[ 5 ] Joner M, Finn AV, Farb A, Mont EK, Kolodgie FD, Ladich E, et al. Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol 2006;48:193–202. link1

[ 6 ] Onuma Y, Ormiston J, Serruys PW. Bioresorbable scaffold technologies. Circ J 2011;75:509–20. link1

[ 7 ] Iqbal J, Onuma Y, Ormiston J, Abizaid A, Waksman R, Serruys P. Bioresorbable scaffolds: rationale, current status, challenges, and future. Eur Heart J 2014;35:765–76. link1

[ 8 ] Stepak B, Anton´ czak AJ, Bartkowiak-Jowsa M, Filipiak J, Pezowicz C, Abramski KM. Fabrication of a polymer-based biodegradable stent using a CO2 laser. Arch Civ Mech Eng 2014;14:317–26. link1

[ 9 ] Guerra AJ, Farjas J, Ciurana J. Fibre laser cutting of polycaprolactone sheet for stents manufacturing: a feasibility study. Opt Laser Technol 2017;95:113–23. link1

[10] Guerra AJ, Ciurana J. 3D-printed bioabsordable polycaprolactone stent: the effect of process parameters on its physical features. Mater Des 2018;137:430–7. link1

[11] Martinez AW, Chaikof EL. Microfabrication and nanotechnology in stent design. WIREs Nanomed Nanobiotechnol 2011;3:256–68. link1

[12] Kaesemeyer WH, Sprankle KG, Kremsky JN, Lau W, Helmus MN, Ghatnekar GS. Bioresorbable polystatin fourth-generation stents. Coron Artery Dis 2013;24:516–21. link1

[13] Park SA, Lee SJ, Lim KS, Bae IH, Lee JH, Kim WD, et al. In vivo evaluation and characterization of a bio-absorbable drug-coated stent fabricated using a 3Dprinting system. Mater Lett 2015;141:355–8. link1

[14] Wu Z, Zhao J, Wu W, Wang P, Wang B, Li G, et al. Radial compressive property and the proof-of-concept study for realizing self-expansion of 3D printing polylactic acid vascular stents with negative poisson’s ratio structure. Materials 2018;11(8):1357. link1

[15] Wang WQ, Liang DK, Yang DZ, Qi M. Analysis of the transient expansion behavior and design optimization of coronary stents by finite element method. J Biomech 2006;39:21–32. link1

[16] Stoeckel D, Bonsignore C, Duda S. A survey of stent designs. Minim Invasive Ther Allied Technol 2002;11:137–47. link1

[17] Attard D, Grima JN. Modelling of hexagonal honeycombs exhibiting zero Poisson’s ratio. Phys Status Solidi Basic Res 2011;248:52–9. link1

[18] Masters IG, Evans KE. Models for the elastic deformation of honeycombs. Compos Struct 1996;35:403–22. link1

[19] Young WC, Budynas RG. Roark’s formulas for stress and strain. 7th ed. Beijing: Tsinghua University Press; 2003. Chinese. link1

[20] Grima JN, Oliveri L, Attard D, Ellul B, Gatt R, Cicala G, et al. Hexagonal honeycombs with zero Poisson’s ratios and enhanced stiffness. Adv Eng Mater 2010;12:855–62. link1

[21] Venkataraman N, Rangarajan S, Matthewson MJ, Harper B, Safari A, Danforth SC, et al. Feedstock material property—process relationships in fused deposition of ceramics (FDC). Rapid Prototyp J 2000;6:244–52. link1

[22] Liu B, Xie Y, Wu M. Research on the micro-extrusion characteristic of mini-screw in the screw extruding spray head. Polym Bull 2010;64: 727–38. link1

[23] Wang F, Shor L, Darling A, Khalil S, Sun W, Güçeri S, et al. Precision extruding deposition and characterization of cellular poly-e-caprolactone tissue scaffolds. Rapid Prototyp J 2004;10:42–9. link1

[24] Capone C, Di Landro L, Inzoli F, Penco M, Sartore L. Thermal and mechanical degradation during polymer extrusion processing. Polym Eng Sci 2007;47:1813–9. link1

[25] Liu C, Li Y, Zhang L, Mi S, Xu Y, Sun W. Development of a novel lowtemperature deposition machine using screw extrusion to fabricate poly(Llactide-co-glycolide) acid scaffolds. Proc Inst Mech Eng Part H J Eng Med 2014;228:593–606. link1

[26] F2606-08 Standard guide for three-point bending of balloon expandable vascular stents and stent systems. US Standard. West Conshohocken: American Society of Testing Materials; 2014.

[27] F3067-14 Guide for radial loading of balloon expandable and self expanding vascular stents. US Standard. West Conshohocken: American Society of Testing Materials; 2014.

[28] Wang Q, Fang G, Zhao Y, Wang G, Cai T. Computational and experimental investigation into mechanical performances of poly-L-lactide acid (PLLA) coronary stents. J Mech Behav Biomed Mater 2017;65:415–27. link1

[29] Schmidt W, Behrens P, Brandt-Wunderlich C, Siewert S, Grabow N, Schmitz KP. In vitro performance investigation of bioresorbable scaffolds—standard tests for vascular stents and beyond. Cardiovasc Revascularization Med 2016;17:375–83. link1

[30] Schmidt W, Lanzer P, Behrens P, Topoleski LDT, Schmitz KP. A comparison of the mechanical performance characteristics of seven drug-eluting stent systems. Catheter Cardiovasc Interv 2009;73:350–60. link1

[31] Colombo A, Stankovic G, Moses JW. Selection of coronary stents. J Am Coll Cardiol 2002;40:1021–33. link1

[32] F756-17 Standard practice for assessment of hemolytic properties of materials. US Standard. West Conshohocken: American Society of Testing Materials; 2017.

[33] Im SH, Kim CY, Jung Y, Jang Y, Kim SH. Biodegradable vascular stents with high tensile and compressive strength: a novel strategy for applying monofilaments via solid-state drawing and shaped-annealing processes. Biomater Sci 2017;5:422–31. link1

[34] ISO 10993-5:2009 Biological evaluation of medical devices—part 5: tests for in vitro cytotoxicity. EN Standard. Geneva: International Organization for Standardization; 2009.

Related Research