ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC REVIEW
1. Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujibur Rahman Science & Technology University, Gopalganj 8100, Bangladesh.
2. Department of Microbiology and Biochemistry, North South University, Dhaka 1229, Bangladesh.
3. Department of Genetic Engineering and Biotechnology, Jashore University of Science and Technology, Jashore 7408, Bangladesh.
4. Department of Microbiology, University of Dhaka, Dhaka 1000, Bangladesh.
5. Department of Naval Architecture and Marine Engineering, Bangladesh University of Engineering and Technology, Dhaka 1205, Bangladesh.
6. Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh.
7. Department of Mechanical and Production Engineering, Islamic University of Technology, Gazipur 1704, Bangladesh.
8. School of Biotechnology, Jiangnan University, Wuxi 214122, China.
9. Department of Mathematics and Natural Sciences, Brac University, Dhaka 1212, Bangladesh.
10. Department of Pharmacy, Comilla University, Comilla 3506, Bangladesh.
11. Department of Biomedical Technology, Tampere University, Tampere 33100, Finland.
The COVID-19 infections caused by SARS-CoV-2 have resulted in millions of people being infected and thousands of deaths globally since November 2019. To date, no unique therapeutic agent has been developed to slow the progression of this pandemic. Despite possessing antiviral traits the potential of bacteriocins to combat SARS-CoV-2 infection has not been fully investigated. This review summarizes the mechanisms by which bacteriocins can be manipulated and implemented as effective virus entry blockers with infection suppression potential properties to highly transmissible viruses through comprehensive immune modulations that are potentially effective against COVID-19. These antimicrobial peptides have been suggested as effective antiviral therapeutics and therapeutic supplements to prevent rapid virus transmission. This review also provides a new insight into the cellular and molecular alterations which have made SARS-CoV-2 self-modified with diversified infection patterns. In addition, the possible applications of antimicrobial peptides through both natural and induced mechanisms in infection prevention perspectives on changeable virulence cases are comprehensively analyzed. Specific attention is given to the antiviral mechanisms of the molecules along with their integrative use with synthetic biology and nanosensor technology for rapid detection. Novel bacteriocin based therapeutics with cutting-edge technologies might be potential substitutes for existing time-consuming and expensive approaches to fight this newly emerged global threat.