Chip-based waveguides for high-sensitivity biosensing and super-resolution imaging

2020, Volume 21, Issue 8

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Frontiers of Information Technology & Electronic Engineering >> 2020, Volume 21, Issue 8 doi: 10.1631/FITEE.1900211

Chip-based waveguides for high-sensitivity biosensing and super-resolution imaging

Affiliation(s): State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China; Deparment of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China; State Key Laboratory of Modern Optical Instrumentation, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310058, China; Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006, China; less

Received: 2019-04-24 Accepted: 2020-08-10 Available online: 2020-08-10

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Abstract

In this review, we introduce some chip-based waveguide biosensing and imaging techniques, which significantly reduce the complexity of the entire system. These techniques use a well-confined evanescent field to interact with the surrounding materials and achieve high sensitivity sensing and high signal-to-noise ratio (SNR) super-resolution imaging. The fabrication process of these chips is simple and compatible with conventional semiconductor fabrication methods, allowing high-yield production. Combined with recently developed chip-based light sources, these techniques offer the possibility of biosensing and super-resolution imaging based on integrated circuits.

Keywords

Waveguide-based sensing ; Waveguide-based imaging ; Evanescent illumination ; Frequency shifting and stitching

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