Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

2017, Volume 11, Issue 4

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Abstract

Keywords

Frontiers of Chemical Science and Engineering >> 2017, Volume 11, Issue 4 doi: 10.1007/s11705-017-1640-4

Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

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. Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.. Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

Accepted: 2017-05-10 Available online: 2017-11-06

Abstract

Despite limited successes in clinical development, therapeutic cancer vaccines have experienced resurgence in recent years due to an enhanced emphasis upon co-mitigating factors underlying immune response. Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety of cellular and molecular signaling mechanisms, has become fundamental toward enhancing therapeutic efficacy. Therein, our lab has implemented various nano-vaccines based on the lipid-coated calcium phosphate platform for combined immunotherapy, in which antigenic, epitope-associated peptides as well as immune-suppression inhibitors can be co-delivered, often functioning through the same formulation. In probing the mechanism of action of such systems and , an improved effect synergy can be elucidated, inspiring future preclinical efforts and hope for clinical success.

Keywords

vaccine ; nanoparticle ; tumor ; immunotherapy ; microenvironment

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