Based on accelerated carbonation test, 1D, 2D and 3D carbonation of high performance concrete with different fly ash contents (0%, 15%, 20%, 40%, 60%) were studied. The interaction coefficients of 2D and 3D carbonation are defined. The time-dependent coefficient of carbon dioxide diffusion and the interaction coefficients of 2D and 3D carbonation are analyzed. The mathematical model which includes and is deduced. The experiments indicate that 2D and 3D carbonation have obvious interaction. Interaction coefficients obey the attenuation function through time . The mathematical model of 2D and 3D carbonation life prediction based on Fick scattering law can be solved by Fourier expansion. The life prediction of concrete of Sutong Bridge beam shows that the 1D, 2D, 3D carbonation prediction life are 1595 a, 882 a and 758 a, respectively, 2D and 3D carbonation life predicted are reduced clearly.