Traditional on-site fault diagnosis means cannot meet the needs of large rotating machinery for its performance and complexity. Remote monitoring and diagnosis technology is a new fault diagnosis mode combining computer technology, communication technology, and fault diagnosis technology. The designed remote monitoring and diagnosis and prediction system for large rotating machinery integrates the distributed resources in different places and breaks through shortcomings as the offline and decentralized information. The system can make further implementation of equipment prediction technology research based on condition monitoring and fault diagnosis, provide on-site analysis results, and carry out online actual verification of the results. The system monitors real-time condition of the equipment and achieves early fault prediction with great significance to guarantee safe operation, saves maintenance costs, and improves utilization and management of the equipment.