Journal Home Online First Current Issue Archive For Authors Journal Information 中文版

Strategic Study of CAE >> 2001, Volume 3, Issue 11

Fastigial Nucleus Electrical Stimulation and Central Neurogenic Neuroprotection

Institute of neurology of Chongqing medical university, Chongqing 400016, China

Funding project:国家自然科学基金重点项目(39730170);国家自然科学基金面上项目(39370261) Received: 2001-07-19 Revised: 2001-08-06 Available online: 2001-11-20

Next Previous

Abstract

Brian can protect itself from ischemia and/or hypoxia by two distinct mechanisms which probably involve two separate systems of neurons in the CNS. The first ome mediates a reflex neurogenic neuroprotection, which is associated with oxygen-sensitive sympathoexcitatory reticulospinal neurons of rostral ventrolateral medula oblongata. It can be excited within seconds by reduction in blood flow or oxygen and initiate an oxygen conserving reflex. The second is conditioned central neurogenic neuroprotection, which is represented in intrinsic neurons in cerebellar fastigial nucleus. It can be initiated by electrical excitation of intrinsic neurons of fastigial nucleus and afford a persisting for almost two weeks neuroprotection. This mode of neuroprotection is not restricted to focal ischmia,it also protects the brain against global ischemia and excitotoxic cell injury. The ne-oruprotective mechanism of the system is associated with reduced excitability of cortical neurons, inhibition of the onset of necrosis and apoptosis of ischemic neurons, reduced expression of many detrimental factors including Caspase-3 and NF-kappaB, and reduced immunoreactivity of cerebral microvessels. Fastigial neucleus stimulation can also promote the recovery of neurological deficits and can somewhat improve the cognitive function. Some prelimilary observations of clinical application of fastigial nucleus electrical stimulation on protecting neurons from ischemic injury and treating patients with stroke are presented. Recommendations of further research on fastigial nucleus stimulation before its broad clinical practice are provided.

Figures

图1

图2

图3

图4

图5

图6

图7

References

[ 1 ] ReisDJ , GolanovEV , GaleaE , atalCentralneuro genicneuroprotection:centralnevoussystemsthatprotectthebrainfromhypoxiaandischemia[J].AnnNYAcadSci, 1997, 19 (835) :168~186

[ 2 ] 夏一鲁, 罗 勇, 董为伟, 等.电刺激小脑顶核对脑卒中大鼠的治疗作用与机制[J].中风与神经疾病杂志, 1999, 16 (1) :3~5 link1

[ 3 ] GolanovEV , ChristensenJD , ReisDJ.Roleofpotas siumchannelsinthecentralneurogenicneuroprotectionelicitedbycerebellarstimulationinrat[J].BrainRes, 1999, 842 (2) :496~500

[ 4 ] GolanovEV , ReisDJ.Neuroprotectiveelectricalstim ulationofcerebellarfastigialnucleusattenuatesexpres sionofperiinfarctiondepolarizingwaves (PIDS) andin hibitscorticalspreadingdepression[J].BrainRes, 1999, 818 (2) :304~15

[ 5 ] GlicksteinSB , GolanovEVandReisDJ .Intrinsicneuronsoffastigialnucleusmediateneurogenicneuro protectionagainstexcitotoxicandischemicneuronalin juryinrat[J].JNeurosci, 1999, 19 (10) :412~54

[ 6 ] 余 刚, 董为伟, 彭国光, 等.预刺激小脑顶核对脑缺血神经元凋亡的防治作用[J].现代康复, 2001, 5 (1) :60~61 link1

[ 7 ] GaleaE , GlicksteinSB , FeinsteinDL , etal.Stimula tionofcerebellarfastigialnucleuinhibitsinterleukin1beta inducedcerebrovascularinflammation[J].AmJPhysiol, 1998, 275 (6Pt2) :H2053~63

[ 8 ] 杨 军, 张拥波, 董为伟, 等.电刺激小脑治疗脑血管疾病的疗效初步观察[J].临床神经病学杂志, 1997, 10 (6) :370~372 link1

[ 9 ] 冯爱玉, 宋承伟, 杨 红, 等.急性脑梗死电刺激小脑对肢体运功能恢复的疗效[J].第二军医大学学报, 1999, 20 (10) :817~818 link1

[10] 吴方霞, 张 强, 宋素君, 等.小脑顶核电刺激对脑外伤患者脑血流速度和颅内压的影响[J].中风与神经疾病杂志, 2000, 17 (3) :147~148 link1

[11] 王 红, 张 虹, 王 菲, 等.电刺激小脑顶核治疗视网膜中央动脉阻塞疗效的观察[J].卒中与神经疾病, 2000, 7 (3) :170~172 link1

[12] 李长清, 董为伟.大脑半球卒中患者的心脏自主神经活性与心电图改变[J].中国神经精神病学杂志, 1996, 22 (3) :164~166 link1

Related Research