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Astrocytes in depression and Alzheimer’s disease

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 829-841 doi: 10.1007/s11684-021-0875-0

Abstract: multiple chronic brain diseases may cause psychosocial and cognitive impairment, such as depression and Alzheimer’s disease (AD).depression and AD has shown that depression might be a prodrome of progressive degenerative neurological disease

Keywords： astrocytes     depression     Alzheimer’s disease     roles     mechanisms    

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Protein phosphatase 2A, a key player in Alzheimer’s disease

Rong LIU, Qing TIAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 8-12 doi: 10.1007/s11684-009-0017-6

Abstract: In the brains of patients with Alzheimer’s disease (AD), decreased PP2A activities were observed, whichFurther studies are required to disclose the role of PP2A in Alzheimer’s disease.

Keywords： protein phosphatase 2A     Alzheimer’s disease     holoenzyme composition     protein phosphatase 2A inhibitors     Leu309    

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Effect of ambient polycyclic aromatic hydrocarbons and nicotine on the structure of Aβ protein

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 2, doi: 10.1007/s11783-023-1615-2

Abstract:

● B[a]P, nicotine and phenanthrene molecules altered the secondary structure of Aβ42.

Keywords： Polycyclic aromatic hydrocarbons     Nicotine     toxicology     Aβ42 peptide     Alzheimer’s disease    

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Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 433-444 doi: 10.1007/s11705-014-1454-6

Abstract: The aggregation of amyloid -protein (A ) is tightly linked to the pathogenesis of Alzheimer’s disease

Keywords： Alzheimer’s disease     amyloid β-protein     peptide inhibitors     protein-protein interaction     molecular    

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Head-to-tail cyclization of a heptapeptide eliminates its cytotoxicity and significantly increases its inhibition effect on amyloid

Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 2,   Pages 283-295 doi: 10.1007/s11705-017-1687-2

Abstract: Amyloid- (A ) protein aggregation is the main hallmark of Alzheimer’s disease (AD).

Keywords： Alzheimer’s disease     amyloid β-protein     cyclic peptide     inhibition     protein aggregation    

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et’s disease in a Chinese population

Shengping Hou, Aize Kijlstra, Peizeng Yang

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 354-359 doi: 10.1007/s11684-012-0234-2

Abstract: et’s disease is defined as a multisystemic inflammatory disease.et’s disease. To explore the genetic factors for Beh?et’s disease, our group investigated the association of Beh?et’s disease with multiple immune response genes and has identified multiple Beh?et’s disease-related immunoregulatory pathways in the Chinese Han population.

Keywords： et’s disease     SNPs     immune gene     genetic study    

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Altered white matter microarchitecture in Parkinson’s disease: a voxel-based meta-analysis of diffusion

Xueling Suo, Du Lei, Wenbin Li, Lei Li, Jing Dai, Song Wang, Nannan Li, Lan Cheng, Rong Peng, Graham J Kemp, Qiyong Gong

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 125-138 doi: 10.1007/s11684-019-0725-5

Abstract: This study aimed to define the most consistent white matter microarchitecture pattern in Parkinson’sdisease (PD) reflected by fractional anisotropy (FA), addressing clinical profiles and methodology-relatedSubgroup analyses were conducted considering heterogeneity with respect to medication status, disease

Keywords： Parkinson’s disease     diffusion tensor imaging     fractional anisotropy     meta-analysis     anisotropic effect size–signed    

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Medical applications of phytoestrogens from the Thai herb

Suchinda Malaivijitnond

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 8-21 doi: 10.1007/s11684-012-0184-8

Abstract:

Pueraria mirifica Airy Shaw et Suvatabandhu is a medicinal plant endemic to Thailand. It has been used in Thai folklore medicine for its rejuvenating qualities in aged women and men for nearly one hundred years. Indeed, it has been claimed that P. mirifica contains active phytoestrogens (plant substances with estrogen-like activity). Using high performance liquid chromatography, at least 17 phytoestrogens, mainly isoflavones, have been isolated. Thus, fairly considerable scientific researches, both in vitro in cell lines and in vivo in various species of animals including humans, have been conducted to date to address its estrogenic activity on the reproductive organs, bones, cardiovascular diseases and other climacteric related symptoms. The antioxidative capacity and antiproliferative effect on tumor cell lines have also been assessed. In general, P. mirifica could be applicable for preventing, or as a therapeutic for, the symptoms related to estrogen deficiency in menopausal women as well as in andropausal men. However, the optimal doses for each desirable effect and the balance to avoid undesired side effects need to be calculated before use.

Keywords： white Kwao Krua     miroestrol     estrogenic activity     reproduction     osteoporosis     breast cancer     Alzheimer    

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Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 425-432 doi: 10.1007/s11684-013-0295-x

Abstract:

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality

Keywords： chronic obstructive pulmonary disease     heterogeneity     phenotype     genotype     prediction    

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Acupuncture for the management of dry eye disease

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 975-983 doi: 10.1007/s11684-022-0923-4

Abstract: The effectiveness of using acupuncture for dry eye disease (DED) is controversial.outcomes of interests were (1) to evaluate the efficacy of acupuncture in improving the ocular surface disease

Keywords： dry eye disease     xerophthalmus     acupuncture    

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Exploration of Strategies for Chronic Disease Prevention and Control and Relevant System Development

Long-de Wang

Frontiers of Engineering Management 2015, Volume 2, Issue 1,   Pages 2-12 doi: 10.15302/J-FEM-2015002

Abstract: acceleration of industrialization and urbanization, along with population aging and rapid changes of people’sthe status of major chronic diseases in China, analyzing the key issues and key factors in chronic diseasethe previous projects, this paper proposes the following recommendations as strategies for chronic diseaseWork norms and requirements will then improve the performance and efficiency in chronic disease prevention

Keywords： chronic disease prevention and control     strategy and system construction    

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Zooming in and out of ferroptosis in human disease

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 173-206 doi: 10.1007/s11684-023-0992-z

Abstract: ferroptosis and its regulatory pathways could provide additional strategies for the management of these disease, we summarize the progress in the research into ferroptosis and its regulatory mechanisms in human diseaseWe also discuss our perspectives on the future directions in the targeting of ferroptosis in human disease

Keywords： ferroptosis     human disease     iron metabolism     lipid peroxidation     antioxidation    

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Multislice computed tomography angiography in the diagnosis of cardiovascular disease: 3D visualizations

Zhonghua Sun

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 254-270 doi: 10.1007/s11684-011-0153-7

Abstract: computed tomography (CT) has been widely used in clinical practice for the diagnosis of cardiovascular diseaseangiography has been recognized as the method of choice for detecting and diagnosing head and neck vascular diseaseIn patients with suspected coronary artery disease, although invasive coronary angiography still remainsThe imaging diagnosis of cardiovascular disease is based on a combination of two-dimensional (2D) andan overview of the diagnostic performance of various 2D and 3D CT visualizations in cardiovascular disease

Keywords： cardiovascular disease     multislice computed tomography     three-dimensional reconstruction     diagnosis     visualization    

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Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 58-67 doi: 10.1007/s11684-022-0937-y

Abstract: Group D restrictive lung disease was the main indication of a lung transplant in recipients over 65 years

Keywords： cardiac disease     mortality     aged population     lung transplantation    

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The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes

Honglu Zhou, Songmei Wang, Lorenz von Seidlein, Xuanyi Wang

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 1-7 doi: 10.1007/s11684-019-0733-5

Abstract: With the improvements of sanitation and nationwide safe water supply the occurrence of bacterial diarrhea declined remarkably, while viruses became the leading causes of acute gastroenteritis (AGE). Of these viruses, noroviruses (NoVs) are responsible for a considerable burden of gastroenteritis, especially in children<2 years and elderly≥65 years. NoVs circulating in the Chinese population are antigenically highly diverse with the genotype GII.4 being the dominant strain followed by GII.3. Given the widespread contamination in environmental sources, and highly infectious nature of NoVs, vaccination would be the desirable strategy for the control of NoV infections. However, a better understanding of acquired immunity after infection, and a reliable immunological surrogate marker are urgently needed, since two vaccine candidates based on virus-like particles (VLPs) are currently moving into clinical evaluations in China.

Keywords： molecular epidemiology     norovirus     disease burden     genotype     China    

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Title Author Date Type Operation

Astrocytes in depression and Alzheimer’s disease

Journal Article

Protein phosphatase 2A, a key player in Alzheimer’s disease

Rong LIU, Qing TIAN

Journal Article

Effect of ambient polycyclic aromatic hydrocarbons and nicotine on the structure of Aβ protein

Journal Article

Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Journal Article

Head-to-tail cyclization of a heptapeptide eliminates its cytotoxicity and significantly increases its inhibition effect on amyloid

Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun

Journal Article

et’s disease in a Chinese population

Shengping Hou, Aize Kijlstra, Peizeng Yang

Journal Article

Altered white matter microarchitecture in Parkinson’s disease: a voxel-based meta-analysis of diffusion

Xueling Suo, Du Lei, Wenbin Li, Lei Li, Jing Dai, Song Wang, Nannan Li, Lan Cheng, Rong Peng, Graham J Kemp, Qiyong Gong

Journal Article

Medical applications of phytoestrogens from the Thai herb

Suchinda Malaivijitnond

Journal Article

Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Journal Article

Acupuncture for the management of dry eye disease

Journal Article

Exploration of Strategies for Chronic Disease Prevention and Control and Relevant System Development

Long-de Wang

Journal Article

Zooming in and out of ferroptosis in human disease

Journal Article

Multislice computed tomography angiography in the diagnosis of cardiovascular disease: 3D visualizations

Zhonghua Sun

Journal Article

Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients

Journal Article

The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes

Honglu Zhou, Songmei Wang, Lorenz von Seidlein, Xuanyi Wang

Journal Article