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Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis

Frontiers of Medicine   Pages 873-882 doi: 10.1007/s11684-022-0925-2

Abstract: Treatment with VNP-Tum5 effectively suppressed tumor growth and prolonged survival in the mouse model of B16F10exhibited a higher efficacy in inhibiting the proliferation and inducing the necrosis and apoptosis of B16F10cell adhesion molecule-1, phosphorylated phosphoinositide 3 kinase, and phosphorylated protein kinase B

Keywords： Salmonella VNP20009     tumstatin     B16F10     melanoma     apoptosis     angiogenesis    

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Zfyve16 regulates the proliferation of B-lymphoid cells

Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 559-565 doi: 10.1007/s11684-017-0562-3

Abstract: However, the in vivo function of Zfyve16 remains unknown.In this study, we generated a Zfyve16 knockout mouse strain (Zfyve16KOB cell proliferation is inhibited in Zfyve16KO mice.The proliferation potential of Zfyve16KO B-lymphoid cells also significantlysignaling, but upregulates the proliferation of B-lymphoid cells.

Keywords： Zfyve16     endofin     hematopoiesis     TGF-β     lymphocytes    

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Overall design and realization of selectivity leakage protection device in mines

Sun Yukun,Zhu Zhiying,Huang Zhenyue,Tang Ping

Strategic Study of Chinese Academy of Engineering 2012, Volume 14, Issue 7,   Pages 93-97

Abstract: justify;">A novel selective leakage protective device in master-slave structure was proposed where dsPIC30F4012was the master controller and PIC16F877A was the slave processor.

Keywords： leakage protection     selectivity     dsPIC30F4012     PIC16F877A     RS-485 bus     optical fiber communication    

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Effect of process parameters on the density and porosity of laser melted AlSi10Mg/SiC metal matrix composite

FAMODIMU, Mark STANFORD, Chike F. ODUOZA, Lijuan ZHANG

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 4,   Pages 520-527 doi: 10.1007/s11465-018-0521-y

Abstract:

Laser melting of aluminium alloy—AlSi10Mg has increasingly been used to create specialised productsThis included single track formations of the matrix alloy and the composite alloyed with 5% and 10% respectively

Keywords： selective laser melting     additive manufacturing     mechanical alloying     powder metallurgy     aluminium metal matrix composite    

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Impact analysis of compressor rotor blades of an aircraft engine

Y B SUDHIR SASTRY, B G KIROS, F HAILU, P R BUDARAPU

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 3,   Pages 505-514 doi: 10.1007/s11709-018-0493-3

Abstract: Frequent failures due to foreign particle impacts are observed in compressor blades of the interceptor fighter MIG-23 aircraft engines in the Ethiopian air force, supplied by the Dejen Aviation Industry. In this paper, we made an attempt to identify the causes of failure and hence recommend the suitable materials to withstand the foreign particle impacts. Modal and stress analysis of one of the recently failed MIG-23 gas turbine compressor blades made up of the following Aluminum based alloys: 6061-T6, 7075-T6, and 2024-T4, has been performed, apart from the impact analysis of the rotor blades hit by a granite stone. The numerical results are correlated to the practical observations. Based on the modal, stress and impact analysis and the material properties of the three considered alloys, alloy 7075-T6 has been recommended as the blade material.

Keywords： axial flow compressor     rotor and stator blades     aircraft engine     stress and impact analysis     aluminum alloys    

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MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 72-80 doi: 10.15302/J-FASE-2016089

Abstract: In our study, we found by qRT-PCR that miR-148b was significantly upregulated in sheep wool follicleOverexpression of miR-148b promoted proliferation of both HHDPC and HHGMC.By using the TOPFlash system we demonstrated that miR-148b could activate Wnt/β-catenin pathway andfactor nuclear factor of activated T cells type 5 ( ) and were predicted to be the target of miR-148bSubsequently was further identified as the target of miR-148b using western blotting.

Keywords： miR-148b     hair follicle     proliferation     NFAT5     Wnt10b    

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Best operating conditions to produce hydroxyapatite nanoparticles by means of a spinning disc reactor

F. D’ Intino,B. de Caprariis,M.L. Santarelli,N. Verdone,A. Chianese

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2,   Pages 156-160 doi: 10.1007/s11705-014-1427-9

Abstract: By operating at pH= 10, a high purity Mg-HAP nanoparticles were obtained.

Keywords： hydroxyapatite     nanoparticles     spinning disc reactor    

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Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa

DING Xiaofang, LI Honggang, XIONG Chengliang

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 195-199 doi: 10.1007/s11684-008-0037-7

Abstract: counting the number of spermatozoa that migrated into the capillary after incubation with uPA for 5, 10, 20, and 30 min, respectively, compared with that after incubation with F10.rabbit IgG may affect sperm accumulation nonspecifically, PAI-1 and anti-uPAR rabbit IgG were added to F10

Keywords： chemotactic activity     receptor     uPA inhibitor     F10     chemoattractant    

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3D Photo-Fabrication for Tissue Engineering and Drug Delivery Review

Rúben F. Pereira, Paulo J. Bártolo

Engineering 2015, Volume 1, Issue 1,   Pages 90-112 doi: 10.15302/J-ENG-2015015

Abstract:

The most promising strategies in tissue engineering involve the integration of a triad of biomaterials, living cells, and biologically active molecules to engineer synthetic environments that closely mimic the healing milieu present in human tissues, and that stimulate tissue repair and regeneration. To be clinically effective, these environments must replicate, as closely as possible, the main characteristics of the native extracellular matrix (ECM) on a cellular and subcellular scale. Photo-fabrication techniques have already been used to generate 3D environments with precise architectures and heterogeneous composition, through a multi-layer procedure involving the selective photocrosslinking reaction of a light-sensitive prepolymer. Cells and therapeutic molecules can be included in the initial hydrogel precursor solution, and processed into 3D constructs. Recently, photo-fabrication has also been explored to dynamically modulate hydrogel features in real time, providing enhanced control of cell fate and delivery of bioactive compounds. This paper focuses on the use of 3D photo-fabrication techniques to produce advanced constructs for tissue regeneration and drug delivery applications. State-of-the-art photo-fabrication techniques are described, with emphasis on the operating principles and biofabrication strategies to create spatially controlled patterns of cells and bioactive factors. Considering its fast processing, spatiotemporal control, high resolution, and accuracy, photo-fabrication is assuming a critical role in the design of sophisticated 3D constructs. This technology is capable of providing appropriate environments for tissue regeneration, and regulating the spatiotemporal delivery of therapeutics.

Keywords： 3D photo-fabrication     biomaterials     tissue engineering     drug delivery    

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4-Amino-1,8-naphthalimide based fluorescent photoinduced electron transfer (PET) pH sensors as liposomal cellular imaging agents: The effect of substituent patterns on PET directional quenching

Bright, Emma B. Veale, Adam F. Henwood, D. Clive Williams, Thorfinnur Gunnlaugsson

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 1,   Pages 61-75 doi: 10.1007/s11705-019-1862-8

Abstract: Four new fluorescent sensors ( - ) based on the 4-amino-1,8-naphthalimide fluorophores ( ) have been synthesized based on the classical fluorophore-spacer-receptor model. These four compounds all gave rise to emission bands centred at 535 nm, which were found to be highly pH dependent, the emission being ‘switched on’ in acidic media, while being quenched due to PET from the amino moieties to the excited state of the at more alkaline pH. The luminescent pH dependence for these probes was found to be highly dependent on the substitution on the imide site, as well as the polyamine chain attached to the position 4-amino moiety. In the case of sensor the presence of the 4-amino-aniline dominated the pH dependent quenching. Nevertheless, at higher pH, PET quenching was also found to occur from the polyamine site. Hence, is better described as a receptor -spacer -fluorophore-spacer -receptor system, where the dominant PET process is due to (normally less favourable) ‘directional’ PET quenching from the 4-amino-aniline unit to the site. Similar trends and pH fluorescence dependences were also seen for and . These compounds were also tested for their imaging potential and toxicity against HeLa cells (using DRAQ5 as nuclear stain which does now show pH dependent changes in acidic and neutral pH) and the results demonstrated that these compounds have reduced cellular viability at moderately high concentrations (with IC values between ca. 8‒30 µmol∙L ), but were found to be suitable for intracellular pH determination at 1 µmol∙L concentrations, where no real toxicity was observed. This allowed us to employ these as lysosomal probes at sub-toxic concentrations, where the based emission was found to be pH depended, mirroring that seen in aqueous solution for , with the main fluorescence changes occurring within acidic to neutral pH.

Keywords： sensors     pH     photoinduced electron transfer     cellular imaging     confocal microscopy    

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Characterization and catalytic properties of mesoporous CuO/SBA-16 prepared by different impregnation

DONG Yongli, YUAN Fulong, ZHU Yujun, ZHAO Lina, CAI Zhicheng

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 2,   Pages 150-154 doi: 10.1007/s11705-008-0036-x

Abstract: CuO/SBA-16 catalysts were prepared by two different routes – the conventional impregnation method andreduction (H-TPR) measurements which reveal that the cubic cage-like () pore structure of the parent SBA-16The CuO/SBA-16 prepared by modified impregnation method has a single highly dispersed CuO which is consideredCuO/SBA-16 prepared by the conventional impregnation method shows the presence of bulk CuO species which

Keywords： different     CuO/SBA-16     temperature     physisorption     introduction    

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Development status of hot rolled dual-phase steel and development of high strength hot rolled dual-phase steel

Yuan Guo,Li Chengning,Sun Dandan,Kang Jian and Wang Guodong

Strategic Study of Chinese Academy of Engineering 2014, Volume 16, Issue 2,   Pages 39-45

Abstract: dual-phase steel，and points out that the development and application of low-cost hot rolled dual-phase steel，F-B

Keywords： hot rolled dual- phase steel     low- cost     F- B dual- phase steel     precipitation strengthening     TiC     high strength    

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Vented Individual Patient (VIP) Hoods for the Control of Infectious Airborne Diseases in Healthcare Facilities Review

Patel, F. McGain, T. Bhatelia, S. Wang, B. Sun, J. Monty, V. Pareek

Engineering 2022, Volume 15, Issue 8,   Pages 126-132 doi: 10.1016/j.eng.2020.12.024

Abstract:

By providing a means of separating the airborne emissions of patients from the air breathed by healthcare workers (HCWs), vented individual patient (VIP) hoods, a form of local exhaust ventilation (LEV), offer a new approach to reduce hospital-acquired infection (HAI). Results from recent studies have demonstrated that, for typical patient-emitted aerosols, VIP hoods provide protection at least equivalent to that of an N95 mask. Unlike a mask, hood performance can be easily monitored and HCWs can be alerted to failure by alarms. The appropriate use of these relatively simple devices could both reduce the reliance on personal protective equipment (PPE) for infection control and provide a low-cost and energy-efficient form of protection for hospitals and clinics. Although the development and deployment of VIP hoods has been accelerated by the coronavirus disease 2019 (COVID-19) pandemic, these devices are currently an immature technology. In this review, we describe the state of the art of VIP hoods and identify aspects in need of further development, both in terms of device design and the protocols associated with their use. The broader concept of individual patient hoods has the potential to be expanded beyond ventilation to the provision of clean conditions for individual patients and personalized control over other environmental factors such as temperature and humidity.

Keywords： COVID-19     Vented individual patient hood     Airborne transmission     Healthcare worker     Infectious disease    

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibitspublic databases containing 64 517 patients of 33 cancer types, we found that the expression of Siglec10In particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRCIn 131 KIRC patients of our settings, Siglec10 was elevated in the tumor tissues of 83 (63.4%) patientsMoreover, higher level of Siglec10 was associated with advanced disease (stages III and IV) and worse

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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Antifungal and antibacterial functions of medicinal leech recombinant destabilase-lysozyme and its heated-up derivative

F. PISKUNKOVA, I. B. PAVLOVA, L. L. ZAVALOVA, I. P. BASKOVA

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 203-209 doi: 10.1007/s11705-012-1277-2

Abstract: Antifungal activity of recombinant medicinal leech destabilase-lysozyme (rec.Dest-Lys) was investigated by using fungi: , and , including yeasts and . Its antibacterial activity was investigated on gram-negative bacteria . These activities were assessed by radial agar diffusion assay, and scanning and transmission electron microscopy. Therefore, destabilase-lysozyme not only is endo-isopeptidase and lysozyme, but also has antifungal and antibacterial activities. Muramidase activity of rec.Dest-Lys disappeared after heat-treating at 90°C for 50 min without the loss of its antimicrobial activity. Furthermore we showed for the first time that the heated-up derivative of rec.Dest-Lys exhibited more potent activities against the above enumerated fungi and gram-negative bacteria than original protein.

Keywords： recombinant destabilase-lysozyme (rec.Dest-Lys)     antimicrobial activity     antifungal activity     medicinal leech     heated-up derivative of rec.Dest-Lys (T-rec.Dest-Lys)    

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Title Author Date Type Operation

Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis

Journal Article

Zfyve16 regulates the proliferation of B-lymphoid cells

Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren

Journal Article

Overall design and realization of selectivity leakage protection device in mines

Sun Yukun,Zhu Zhiying,Huang Zhenyue,Tang Ping

Journal Article

Effect of process parameters on the density and porosity of laser melted AlSi10Mg/SiC metal matrix composite

FAMODIMU, Mark STANFORD, Chike F. ODUOZA, Lijuan ZHANG

Journal Article

Impact analysis of compressor rotor blades of an aircraft engine

Y B SUDHIR SASTRY, B G KIROS, F HAILU, P R BUDARAPU

Journal Article

MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Journal Article

Best operating conditions to produce hydroxyapatite nanoparticles by means of a spinning disc reactor

F. D’ Intino,B. de Caprariis,M.L. Santarelli,N. Verdone,A. Chianese

Journal Article

Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa

DING Xiaofang, LI Honggang, XIONG Chengliang

Journal Article

3D Photo-Fabrication for Tissue Engineering and Drug Delivery

Rúben F. Pereira, Paulo J. Bártolo

Journal Article

4-Amino-1,8-naphthalimide based fluorescent photoinduced electron transfer (PET) pH sensors as liposomal cellular imaging agents: The effect of substituent patterns on PET directional quenching

Bright, Emma B. Veale, Adam F. Henwood, D. Clive Williams, Thorfinnur Gunnlaugsson

Journal Article

Characterization and catalytic properties of mesoporous CuO/SBA-16 prepared by different impregnation

DONG Yongli, YUAN Fulong, ZHU Yujun, ZHAO Lina, CAI Zhicheng

Journal Article

Development status of hot rolled dual-phase steel and development of high strength hot rolled dual-phase steel

Yuan Guo,Li Chengning,Sun Dandan,Kang Jian and Wang Guodong

Journal Article

Vented Individual Patient (VIP) Hoods for the Control of Infectious Airborne Diseases in Healthcare Facilities

Patel, F. McGain, T. Bhatelia, S. Wang, B. Sun, J. Monty, V. Pareek

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

Antifungal and antibacterial functions of medicinal leech recombinant destabilase-lysozyme and its heated-up derivative

F. PISKUNKOVA, I. B. PAVLOVA, L. L. ZAVALOVA, I. P. BASKOVA

Journal Article