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Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 745-759 doi: 10.1007/s11684-021-0880-3

Abstract: Lingguizhugan Decoction (LGZG) has been investigated in basic studies, with satisfactory effects on insulin resistance in non-alcoholic fatty liver disease (NAFLD). This translational approach aimed to explore the effect and underlying mechanism of LGZG in clinical setting. A randomized, double-blinded, placebo-controlled trial was performed. A total of 243 eligible participants with NAFLD were equally allocated to receive LGZG (two groups: standard dose and low dose) or placebo for 12 weeks on the basis of lifestyle modifications. The primary efficacy variable was homeostasis model assessment of insulin resistance (HOMA-IR). Analyses were performed in two populations in accordance with body mass index (BMI; overweight/obese, BMI ≥ 24 kg/m2; lean, BMI < 24 kg/m 2). For overweight/obese participants, low-dose LGZG significantly decreased their HOMA-IR level compared with placebo (−0.19 (1.47) versus 0.08 (1.99),P = 0.038). For lean subjects, neither dose of LGZG showed a superior effect compared with placebo. Methylated DNA immunoprecipitation sequencing and real-time qPCR found that the DNA N6-methyladenine modification levels of protein phosphatase 1 regulatory subunit 3A (PPP1R3A) and autophagy related 3 (ATG3) significantly increased after LGZG intervention in overweight/obese population. Low-dose LGZG effectively improved insulin resistance in overweight/obese subjects with NAFLD. The underlying mechanism may be related to the regulation of DNA N6-methyladenine modification of PPP1R3A and ATG3. Lean subjects may not be a targeted population for LGZG.

Keywords： insulin resistance     non-alcoholic fatty liver disease     Chinese herbal medicine     randomized controlled    

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The Globalization of Traditional Medicines: Perspectives Related to the European Union Regulatory Environment Perspective

Werner Knoess, Jacqueline Wiesner

Engineering 2019, Volume 5, Issue 1,   Pages 22-31 doi: 10.1016/j.eng.2018.11.012

Abstract: medicinal products and traditional herbal medicinal products.The standards defined by the EU herbal monographs of the Committee on Herbal Medicinal Products (HMPCmedicines from traditional Chinese medicine (TCM) to gain access to the EU market.provides specific guidance documents and pilot projects on monographs on the safety and efficacy of Chineseherbal drugs.

Keywords： Traditional medicine     Traditional Chinese medicine     Committee on Herbal Medicinal Products     Herbal medicines    

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Prospect in Creating New Drugs from Chinese Herbal Medicine

Yu Dequan

Strategic Study of CAE 1999, Volume 1, Issue 2,   Pages 87-90

Abstract: herbal medicine has proved to be one of the most effective ways for the development of new drugs.

The key point of study on the chemical constituents of individual Chinese herbal medicine hasto be shifted to composite Chinese medicine especially for quality control in the future.study of the chemical constituents of composite Chinese medicine.Study on the bioactive principle of Chinese herbal medicine involves an integration of chemical study

Keywords： natural product research     creating new drug     chemical constituent of Chinese herbal medicine     modem spectroscopic    

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The Scientific Foundation of Chinese Herbal Medicine against COVID-19 Perspective

Elaine Lai-Han Leung, Hu-Dan Pan, Yu-Feng Huang, Xing-Xing Fan, Wan-Ying Wang, Fang He, Jun Cai, Hua Zhou, Liang Liu

Engineering 2020, Volume 6, Issue 10,   Pages 1099-1107 doi: 10.1016/j.eng.2020.08.009

Abstract: Traditional Chinese medicine could be used as an alternative treatment option or in combination withWestern medicine to treat COVID-19, due to its basis on historical experience and holistic pharmacologicalHere, we summarize the potential uses and therapeutic mechanisms of Chinese herbal formulas (CHFs) from

Keywords： Coronavirus disease 2019     Severe acute respiratory syndrome coronavirus     Chinese herbal medicine     Antiviral    

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Individualized medicine, health medicine, and constitutional theory in Chinese medicine

Qi Wang

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 1-7 doi: 10.1007/s11684-012-0173-y

Abstract: The Chinese constitutional theory developed in the 1970s expresses the principle behind Chinese healthmedicine and individual treatment and provides the corresponding methods.The Chinese constitutional theory divides the constitution of the Chinese population into nine categoriesIt promotes the study of the relationship of each constitution to diseases and Chinese medicine preparationmedicine treatment and health medicine for the international medical community.

Keywords： individualized medicine     health medicine     constitutional theory in Chinese medicine    

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Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019

Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 752-759 doi: 10.1007/s11684-020-0813-6

Abstract: This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical

Keywords： COVID-19     CHM     mortality     a retrospective cohort study    

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Clinical research of traditional Chinese medicine in big data era

Junhua Zhang,Boli Zhang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 321-327 doi: 10.1007/s11684-014-0370-y

Abstract: of preventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinesemedicine (TCM), and for the post-marketing evaluation of Chinese patent medicines.

Keywords： big data     traditional Chinese medicine     clinical evaluation     evidence based medicine    

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Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China

Jian Wang, Wen Zou

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 123-126 doi: 10.1007/s11684-011-0124-z

Abstract: Traditional Chinese medicine (TCM) has become widely used in the treatment of acquired immune deficiency

Keywords： HIV/AIDS     traditional Chinese medicine    

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Traditional Chinese medicine in the new century

Jianxiang Liu, Zhu Chen

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 111-114 doi: 10.1007/s11684-011-0125-y

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Thinking and practice of accelerating transformation of traditional Chinese medicine from experiencemedicine to evidence-based medicine

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 163-170 doi: 10.1007/s11684-011-0143-9

Abstract: The gradual development of Chinese medicine is based on constant accumulation and summary of experienceAlthough Chinese medicine has formed a systematic and unique theory system through thousands of yearsmedicine to Chinese medicine is appearing.important content in the development of Chinese medicine.medicine, as well as transform and develop Chinese medicine from experience medicine to evidence-based

Keywords： Chinese medicine     experience medicine     evidence-based medicine     real world    

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Barriers and countermeasures in developing traditional Chinese medicine in Europe

Yunfang Liu,Zhiping Yang,Jing Cheng,Daiming Fan

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 360-376 doi: 10.1007/s11684-016-0455-x

Abstract:

Traditional Chinese medicine (TCM) is one of the unique cultural treasures of Chinese; it representsData in this paper were from World Health Organization, Chinese Bureau of Statistics, China National

Keywords： traditional Chinese medicine     Europe     development    

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The Origin of Traditional Chinese Medicine and Thinking on Chinese Medicine Development

Wang Wenkui,Wang Feng,Wang Ling

Strategic Study of CAE 2006, Volume 8, Issue 4,   Pages 1-11

Abstract:

A principle of “Adopting the advanced part of Western medicine to serve the TCM”should be adhered to for the traditional Chinese medicine.It is necessary not only prepare the medicine in advance according to the predicted disease of the year

Keywords： traditional Chinese medicine (TCM)     development course & status of TCM     adopting the advanced part ofwestern medicine to serve the TCM     the dose type of traditional Chinese medicine    

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Symptom network topological features predict the effectiveness of herbal treatment for pediatric cough

Mengxue Huang, Jingjing Wang, Runshun Zhang, Zhuying Ni, Xiaoying Liu, Wenwen Liu, Weilian Kong, Yao Chen, Tiantian Huang, Guihua Li, Dan Wei, Jianzhong Liu, Xuezhong Zhou

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 357-367 doi: 10.1007/s11684-019-0699-3

Abstract: total of 384 cases were derived from the electronic medical records of a highly experienced traditional Chinesemedicine (TCM) physician.

Keywords： pediatric cough     complex network     symptoms     traditional Chinese medicine     electronic medical records    

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Understanding channel tropism in traditional Chinese medicine in the context of systems biology

Ping Liu, Songlin Liu, Gang Chen, Ping Wang

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 277-279 doi: 10.1007/s11684-013-0273-3

Abstract:

Channel tropism is investigated and developed through long-term clinical practice. In recent years, the development of channel tropism theory has attracted increasing attention. This study analyzed channel tropism theory and the problems associated with it. Results showed that this theory and systems biology have a similar holistic viewpoint. Systems biology could provide novel insights and platform in the study of channel tropism. Some problems in channel tropism theory, including pharmacology and action mechanism, were investigated.

Keywords： systems biology     channel tropism theory     traditional Chinese medicine     application    

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The fundamental theory of traditional Chinese medicine and the consideration in its research strategy

Zhenji Li, Chunbo Xu

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 208-211 doi: 10.1007/s11684-011-0126-x

Abstract: Stressing the uniqueness and complexity of traditional Chinese medicine (TCM) theory system, this paperof TCM should be emphasized on the theoretical research on TCM original thinking theory, TCM theory, Chinese

Keywords： fundamental theory     traditional Chinese medicine     research strategy    

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Title Author Date Type Operation

Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects

Journal Article

The Globalization of Traditional Medicines: Perspectives Related to the European Union Regulatory Environment

Werner Knoess, Jacqueline Wiesner

Journal Article

Prospect in Creating New Drugs from Chinese Herbal Medicine

Yu Dequan

Journal Article

The Scientific Foundation of Chinese Herbal Medicine against COVID-19

Elaine Lai-Han Leung, Hu-Dan Pan, Yu-Feng Huang, Xing-Xing Fan, Wan-Ying Wang, Fang He, Jun Cai, Hua Zhou, Liang Liu

Journal Article

Individualized medicine, health medicine, and constitutional theory in Chinese medicine

Qi Wang

Journal Article

Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019

Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong

Journal Article

Clinical research of traditional Chinese medicine in big data era

Junhua Zhang,Boli Zhang

Journal Article

Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China

Jian Wang, Wen Zou

Journal Article

Traditional Chinese medicine in the new century

Jianxiang Liu, Zhu Chen

Journal Article

Thinking and practice of accelerating transformation of traditional Chinese medicine from experiencemedicine to evidence-based medicine

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

Journal Article

Barriers and countermeasures in developing traditional Chinese medicine in Europe

Yunfang Liu,Zhiping Yang,Jing Cheng,Daiming Fan

Journal Article

The Origin of Traditional Chinese Medicine and Thinking on Chinese Medicine Development

Wang Wenkui,Wang Feng,Wang Ling

Journal Article

Symptom network topological features predict the effectiveness of herbal treatment for pediatric cough

Mengxue Huang, Jingjing Wang, Runshun Zhang, Zhuying Ni, Xiaoying Liu, Wenwen Liu, Weilian Kong, Yao Chen, Tiantian Huang, Guihua Li, Dan Wei, Jianzhong Liu, Xuezhong Zhou

Journal Article

Understanding channel tropism in traditional Chinese medicine in the context of systems biology

Ping Liu, Songlin Liu, Gang Chen, Ping Wang

Journal Article

The fundamental theory of traditional Chinese medicine and the consideration in its research strategy

Zhenji Li, Chunbo Xu

Journal Article