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Cytokines and inflammation in adipogenesis: an updated review

Ning Jiang, Yao Li, Ting Shu, Jing Wang

Frontiers of Medicine 2019, Volume 13, Issue 3, Pages 314-329 doi: 10.1007/s11684-018-0625-0

Abstract: Meanwhile, chronic low-grade inflammation is commonly observed in obese populations.

Keywords： cytokines inflammation adipogenesis type 2 diabetes mellitus metabolic disorder

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Appendiceal inflammation affects the length of stay following appendicectomy amongst children: a myth

Khurram Siddique, Shirin Mirza, Gandra Harinath

Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 264-269 doi: 10.1007/s11684-013-0259-1

Abstract:

The effect of the severity of appendiceal inflammation on post-operative stay in children followingThis study was conducted to determine the association between the severity of appendiceal inflammationThe association of the severity of appendiceal inflammation and post-operative stay was assessed by multivariableMacroscopically perforated appendix, histological inflammation and post-operative complications wereperforated appendix or post-operative complications while it remained unaffected by the histological inflammation

Keywords： appendiceal inflammation post-operative stay paediatrics

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for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on peritoneal inflammation

Zhen Zhang, Na Jiang, Zhaohui Ni

Frontiers of Medicine 2017, Volume 11, Issue 3, Pages 349-358 doi: 10.1007/s11684-017-0571-2

Abstract: Inflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis.peritoneal fibrosis and recent research progress on key fibrogenic molecular mechanisms in peritoneal inflammationFurthermore, novel strategies targeting peritoneal inflammation and angiogenesis to preserve the PM are

Keywords： peritoneal dialysis peritoneal fibrosis inflammation angiogenesis

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Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating

Frontiers of Medicine 2021, Volume 15, Issue 5, Pages 750-766 doi: 10.1007/s11684-021-0839-4

Abstract: Exposure to particulate matter 2.5 (PM2.5) potentially triggers airway inflammation by activating nuclearSirtuin 2 (SIRT2) is a key modulator in inflammation.However, the function and specific mechanisms of SIRT2 in PM2.5-induced airway inflammation are largelyThe activation of p65 triggered airway inflammation, increment of mucus secretion by goblet cells, andMeanwhile, p65 phosphorylation and acetylation, airway inflammation, and bronchial hyperresponsiveness

Keywords： particulate matter 2.5 sirtuin 2 p65 airway inflammation bronchial hyperresponsiveness triptolide

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Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium in inflammation

Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang

Frontiers of Medicine 2021, Volume 15, Issue 4, Pages 638-643 doi: 10.1007/s11684-021-0831-z

Abstract: of overwhelming inflammatory responses in the pathogenesis of COVID-19 and the effectiveness of anti-inflammation

Keywords： COVID-19 endothelial dysfunction inflammation reaction cytokine storm

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Expression of renal cubilin and its potential role in tubulointerstitial inflammation induced by albumin

YANG Jurong, HE Yani, SHEN Haiying, DING Hanlu, LI Kailong, WANG Huiming

Frontiers of Medicine 2008, Volume 2, Issue 1, Pages 25-34 doi: 10.1007/s11684-008-0006-1

Abstract: Over-reabsorption of filtered proteins, notably albumin, has been proved to trigger interstitial inflammationalbumin-induced production of MCP-1 and RANTES by renal tubular cells, which further initiated tubulointerstitial inflammation

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Inflammation and liver tumorigenesis

Beicheng Sun, Michael Karin

Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 242-254 doi: 10.1007/s11684-013-0256-4

Abstract:

Inflammation has been considered as one of the hallmarks of cancer, and chronic hepatitis is a majorThis review will focus on the pathogenic role of inflammation in hepatocarcinogenesis and will discuss

Keywords： hepatocellular carcinoma hepatitis cytokine stem cell miRNA

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Discovery and repurposing of artemisinin

Frontiers of Medicine 2022, Volume 16, Issue 1, Pages 1-9 doi: 10.1007/s11684-021-0898-6

Abstract: We will then discuss how artemisinin and its derivatives could be repurposed to treat cancer, inflammation

Keywords： artemisinin drug repurposing cancer inflammation COVID-19 traditional Chinese medicine

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Plasma transthyretin is a nutritional biomarker in human morbidities

Frontiers of Medicine 2022, Volume 16, Issue 4, Pages 540-550 doi: 10.1007/s11684-022-0940-3

Abstract: Taken together, the data indicate that malnutrition and inflammation may similarly suppress the production

Keywords： lean body mass nutritional status transthyretin malnutrition inflammation amyloidosis

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Mechanisms of insulin resistance in obesity

Jianping Ye

Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 14-24 doi: 10.1007/s11684-013-0262-6

Abstract: In those hypotheses, inflammation, mitochondrial dysfunction, hyperinsulinemia and lipotoxicity have

Keywords： type 2 diabetes energy expenditure inflammation lipotoxicity mitochondria hyperinsulinemia adenosine

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Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives

Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 667-685 doi: 10.1007/s11684-022-0960-z

Abstract: The recovery of A. muciniphila presented benefits in preventing hepatic fat accumulation and inflammationThe modulation mechanisms by which A. muciniphila acts to improve hepatic inflammation are mainly

Keywords： Akkermansia muciniphila NAFLD NASH steatosis inflammation

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Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 139-145 doi: 10.1007/s11684-015-0377-z

Abstract:

In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissue

Keywords： inflammation obesity cytokine energy expenditure insulin resistance

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Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial cells in dry eye disease

Frontiers of Medicine Pages 781-795 doi: 10.1007/s11684-023-0986-x

Abstract: development of dry eye disease (DED) by mediating the disruption of ocular surface homeostasis and triggering inflammationto greatly induce HCECs’ metabolic reprogramming, which may be the primary cause of the subsequent inflammationsuggested that hyperosmolar-induced glycolytic reprogramming played an active role in promoting DED inflammation

Keywords： dry eye disease glycolytic reprogramming pyroptosis inflammation 2-DG

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Biocompatibility Pathways in Tissue-Engineering Templates Perspective

David F. Williams

Engineering 2018, Volume 4, Issue 2, Pages 286-290 doi: 10.1016/j.eng.2018.03.007

Abstract:

Tissue engineering, which involves the creation of new tissue by the deliberate and controlled stimulation of selected target cells through a systematic combination of molecular and mechanical signals, usually involves the assistance of biomaterials-based structures to deliver these signals and to give shape to the resulting tissue mass. The specifications for these structures, which used to be described as scaffolds but are now more correctly termed templates, have rarely been defined, mainly because this is difficult to do. Primarily, however, these specifications must relate to the need to develop the right microenvironment for the cells to create new tissue and to the need for the interactions between the cells and the template material to be consistent with the demands of the new viable tissues. These features are encompassed by the phenomena that are collectively called biocompatibility. However, the theories and putative mechanisms of conventional biocompatibility (mostly conceived through experiences with implantable medical devices) are inadequate to describe phenomena in tissue-engineering processes. The present author has recently redefined biocompatibility in terms of specific materials- and biology-based pathways; this opinion paper places tissue-engineering biocompatibility mechanisms in the context of these pathways.

Keywords： Biomaterials Scaffolds Mechanotransduction Inflammation Topography

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Toll-like receptors in innate immunity and infectious diseases

Min-Hao WU, Ping ZHANG, Xi HUANG,

Frontiers of Medicine 2010, Volume 4, Issue 4, Pages 385-393 doi: 10.1007/s11684-010-0600-x

Abstract: The protective ability of host defense system is largely dependent on germ-line encoded pattern-recognition receptors (PRRs). These PRRs respond to a variety of exogenous pathogens or endogenous danger signals, by recognizing some highly conserved structures such as pathogen-associated molecular patterns (PAMPs) and danger/damage associated molecular patterns (DAMPs). The most studied PRRs are Toll-like receptors (TLRs). Activation of TLRs triggers production of inflammatory cytokines and type I interferons (IFNs) via myeloid differentiation primary response gene 88 (MyD88)-dependent or-independent signaling respectively, thereby modulating innate and adaptive immunity, as well as inflammatory responses. This review introduces the classification, structure, and specific ligands of TLRs, and focuses on their signal pathways and biological activities, as well as clinical relevance. These studies of TLRs in the innate immune system have implications for the prevention and treatment of a variety of infectious diseases, including tuberculosis (TB), microbial keratitis, and hepatitis B and C.

Keywords： Toll-like receptors innate immunity infectious disease inflammation