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The East–West Divide in Response to COVID-19 Article

Dean T Jamison, Kin Bing Wu

Engineering 2021, Volume 7, Issue 7,   Pages 936-947 doi: 10.1016/j.eng.2021.05.008

Abstract: In both the East and the West, stringent population-wide non-pharmaceutical interventions were widely

Keywords： Coronavirus disease 2019     Isolation     Non-pharmaceutical interventions     Pandemic     Vaccination    

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Influenza's Plummeting during the COVID-19 Pandemic: The Roles of Mask-Wearing, Mobility Change, and SARS-CoV-2 Interference Article

Shasha Han, Ting Zhang, Yan Lyu, Shengjie Lai, Peixi Dai, Jiandong Zheng, Weizhong Yang, Xiao-Hua Zhou, Luzhao Feng

Engineering 2023, Volume 21, Issue 2,   Pages 195-202 doi: 10.1016/j.eng.2021.12.011

Abstract: Our results have implications for understanding how influenza evolves under non-pharmaceutical interventions

Keywords： Influenza     Mask-wearing     Mobility mitigation     SARS-CoV-2 interference     Non-pharmaceutical interventions    

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Effective interventions on health effects of Chinese rural elderly under heat exposure

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 5, doi: 10.1007/s11783-022-1545-4

Abstract:

● Education and subsidy were effective interventions during short-term

Keywords： High temperature     Health effect     Comprehensive evaluation     Intervention     Rural elderly    

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Dynamic response surface methodology using Lasso regression for organic pharmaceutical synthesis

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2,   Pages 221-236 doi: 10.1007/s11705-021-2061-y

Abstract: To study the dynamic behavior of a process, time-resolved data are collected at different time instants during each of a series of experiments, which are usually designed with the design of experiments or the design of dynamic experiments methodologies. For utilizing such time-resolved data to model the dynamic behavior, dynamic response surface methodology (DRSM), a data-driven modeling method, has been proposed. Two approaches can be adopted in the estimation of the model parameters: stepwise regression, used in several of previous publications, and Lasso regression, which is newly incorporated in this paper for the estimation of DRSM models. Here, we show that both approaches yield similarly accurate models, while the computational time of Lasso is on average two magnitude smaller. Two case studies are performed to show the advantages of the proposed method. In the first case study, where the concentrations of different species are modeled directly, DRSM method provides more accurate models compared to the models in the literature. The second case study, where the reaction extents are modeled instead of the species concentrations, illustrates the versatility of the DRSM methodology. Therefore, DRSM with Lasso regression can provide faster and more accurate data-driven models for a variety of organic synthesis datasets.

Keywords： data-driven modeling     pharmaceutical organic synthesis     Lasso regression     dynamic response surface methodology    

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Feasibility assessment of up-flow anaerobic sludge blanket treatment of sulfamethoxazole pharmaceutical

Yi Chen, Shilong He, Mengmeng Zhou, Tingting Pan, Yujia Xu, Yingxin Gao, Hengkang Wang

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 5, doi: 10.1007/s11783-018-1069-0

Abstract:

The UASB system successfully treated sulfamethoxazole pharmaceutical

Keywords： Up-flow anaerobic sludge blanket (UASB)     Methane production     Sulfate reduction     Sulfamethoxazole pharmaceutical    

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Biodegradation of trace pharmaceutical substances in wastewater by a membrane bioreactor

Longli BO, Taro URASE, Xiaochang WANG

Frontiers of Environmental Science & Engineering 2009, Volume 3, Issue 2,   Pages 236-240 doi: 10.1007/s11783-009-0004-9

Abstract: The biodegradation of selected pharmaceutical micropollutants, including two pharmaceuticals with argued

Keywords： pharmaceuticals     membrane bioreactor     activated sludge     reaction kinetics    

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Applications of the crystallization process in the pharmaceutical industry

Sohrab ROHANI

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 2-9 doi: 10.1007/s11705-009-0297-z

Abstract: The applications of the crystallization technique in the pharmaceutical industry as a purification andseparation process for the isolation and synthesis of pure active pharmaceutical ingredients (API),

Keywords： feedback     morphology     pulmonary     paracetamol     recognition    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine doi: 10.1007/s11684-023-1025-7

Abstract: Immunotherapies based on immune checkpoint blockade (ICB) have significantly improved patient outcomes and offered new approaches to cancer therapy over the past decade. To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapy. Blockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers, however, a large subset of refractory patients presents poor responsiveness to ICB therapy; and the underlying mechanism remains elusive. Recently, numerous studies have revealed that metabolic reprogramming of tumor cells restrains immune responses by remodeling the tumor microenvironment (TME) with various products of metabolism, and combination therapies involving metabolic inhibitors and ICIs provide new approaches to cancer therapy. Nevertheless, a systematic summary is lacking regarding the manner by which different targetable metabolic pathways regulate immune checkpoints to overcome ICI resistance. Here, we demonstrate the generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4, PD-1, and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies co-targeting tumor metabolic pathways and immune checkpoints.

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic strategies    

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Internet of Things (IoT)–blockchain-enabled pharmaceutical supply chain resilience in the post-pandemic

Frontiers of Engineering Management   Pages 82-95 doi: 10.1007/s42524-022-0233-1

Abstract: During the COVID-19 pandemic, the current operating environment of pharmaceutical supply chain (PSC)

Keywords： pharmaceutical supply chain     Internet of Things     blockchain     resilience     post-pandemic era    

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Machine learning-based solubility prediction and methodology evaluation of active pharmaceutical ingredients

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 4,   Pages 523-535 doi: 10.1007/s11705-021-2083-5

Abstract: The solubility data of 120 active pharmaceutical ingredients (APIs) in ethanol were considered in the

Keywords： solubility prediction     machine learning     artificial neural network     random decision forests    

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Polymorphism of pharmaceutical molecules: perspectives on nucleation

Jie LU, Zhen LI, Xiaolin JIANG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 37-44 doi: 10.1007/s11705-009-0294-2

Abstract: Accordingly, the elucidation of the relationship between the particular polymorph of a pharmaceuticalmolecule and its functional properties is crucial to select the most suitable polymorph of the pharmaceuticalThis review briefly introduces recent advances in the discovery and control of the polymorphs of pharmaceutical

Keywords： development     Polymorphism     elucidation     controversial     relationship    

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Achieving biodegradability enhancement and acute biotoxicity removal through the treatment of pharmaceutical

Liang SUN, Can WANG, Min JI, Fen WANG

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 3,   Pages 481-487 doi: 10.1007/s11783-011-0341-3

Abstract: Actual pharmaceutical wastewater was treated using a combined ultrasonic irradiation (US) and iron/cokebiotoxicity resulted mainly from the destruction of N,N-2 dimethyl formamide and aromatic compounds in the pharmaceutical

Keywords： internal electrolysis     ultrasonic     pharmaceutical wastewater     biodegradability     acute biotoxicity    

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Problems and Countermeasures for Innovative Pharmaceutical Talents Training

You Qidong , Yao Wenbing , Xi Xiaoyu , Fan Chenlin, Yang Bo, Bi Huichang

Strategic Study of CAE 2019, Volume 21, Issue 2,   Pages 79-83 doi: 15302/J-SSCAE-2019.02.006

Abstract:

Based on the strategic background of the transformation of pharmaceuticalresearch from generic drugs to original innovative drugs, the current situation of pharmaceutical personneltraining in China and the problems existing in the process of pharmaceutical personnel training in collegesand universities were summarized in this paper, and some suggestions on the cultivation of innovative pharmaceuticalInnovative pharmaceutical talents should have innovation consciousness, an international vision, interdisciplinary

Keywords： pharmaceutical talents     innovation     comprehensive quality     pharmaceutical industry    

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Analysis and Prospect of the Pharmaceutical Industry Development Trend in China

Kong Fei, Cao Yuan, Xu Ming, Li Haiyan, Qiao Jie

Strategic Study of CAE 2023, Volume 25, Issue 5,   Pages 1-10 doi: 10.15302/J-SSCAE-2023.05.003

Abstract:

The pharmaceutical industry is vital for safeguarding people’sperspective and provides a comprehensive and in-depth comparison regarding the development trends of the pharmaceuticalIt is pointed out that the global market size and strategic position of the pharmaceutical industry inMeanwhile, the development prospects of China’s pharmaceutical industry are broad, and the potentialMoreover, from the perspective of patients, we propose the challenges faced by the pharmaceutical

Keywords： pharmaceutical industry     pharmaceutical research and development     priority strategies     drivers     full    

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Progress of Pharmaceutical Continuous Crystallization Review

Dejiang Zhang, Shijie Xu, Shichao Du, Jingkang Wang, Junbo Gong

Engineering 2017, Volume 3, Issue 3,   Pages 354-364 doi: 10.1016/J.ENG.2017.03.023

Abstract:

Crystallization is an important unit operation in the pharmaceutical industry.At present, most pharmaceutical crystallization processes are performed in batches.This review summarizes the progress in pharmaceutical continuous crystallization from a product engineering

Keywords： Continuous crystallization     Pharmaceutical     MSMPR     Tubular crystallizer     Control strategy    

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Title Author Date Type Operation

The East–West Divide in Response to COVID-19

Dean T Jamison, Kin Bing Wu

Journal Article

Influenza's Plummeting during the COVID-19 Pandemic: The Roles of Mask-Wearing, Mobility Change, and SARS-CoV-2 Interference

Shasha Han, Ting Zhang, Yan Lyu, Shengjie Lai, Peixi Dai, Jiandong Zheng, Weizhong Yang, Xiao-Hua Zhou, Luzhao Feng

Journal Article

Effective interventions on health effects of Chinese rural elderly under heat exposure

Journal Article

Dynamic response surface methodology using Lasso regression for organic pharmaceutical synthesis

Journal Article

Feasibility assessment of up-flow anaerobic sludge blanket treatment of sulfamethoxazole pharmaceutical

Yi Chen, Shilong He, Mengmeng Zhou, Tingting Pan, Yujia Xu, Yingxin Gao, Hengkang Wang

Journal Article

Biodegradation of trace pharmaceutical substances in wastewater by a membrane bioreactor

Longli BO, Taro URASE, Xiaochang WANG

Journal Article

Applications of the crystallization process in the pharmaceutical industry

Sohrab ROHANI

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

Internet of Things (IoT)–blockchain-enabled pharmaceutical supply chain resilience in the post-pandemic

Journal Article

Machine learning-based solubility prediction and methodology evaluation of active pharmaceutical ingredients

Journal Article

Polymorphism of pharmaceutical molecules: perspectives on nucleation

Jie LU, Zhen LI, Xiaolin JIANG,

Journal Article

Achieving biodegradability enhancement and acute biotoxicity removal through the treatment of pharmaceutical

Liang SUN, Can WANG, Min JI, Fen WANG

Journal Article

Problems and Countermeasures for Innovative Pharmaceutical Talents Training

You Qidong , Yao Wenbing , Xi Xiaoyu , Fan Chenlin, Yang Bo, Bi Huichang

Journal Article

Analysis and Prospect of the Pharmaceutical Industry Development Trend in China

Kong Fei, Cao Yuan, Xu Ming, Li Haiyan, Qiao Jie

Journal Article

Progress of Pharmaceutical Continuous Crystallization

Dejiang Zhang, Shijie Xu, Shichao Du, Jingkang Wang, Junbo Gong

Journal Article