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gastroesophageal reflux 2

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Prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran

Fatemeh Mehravar,Soheil Rafiee,Behnaz Bazrafshan,Mahmoud Khodadost

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 345-350 doi: 10.1007/s11684-016-0462-y

Abstract:

Asthma is the most common chronic disease among children, and its incidences are often imminent amongAsthma symptoms were assessed using the questionnaire of the International Study of Asthma and AllergiesThe prevalence rates of “current asthma” symptoms and “asthma ever” in all theThe prevalence of asthma (“asthma ever” and “wheezing in the past 12 months”)Asthma is still a major public health problem.

Keywords： asthma     asthma symptoms     epidemiology     childhood     chronic disease    

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Lung function and air pollution exposure in adults with asthma in Beijing: a 2-year longitudinal panel

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 574-583 doi: 10.1007/s11684-021-0882-1

Abstract: The effect of air pollution on the lung function of adults with asthma remains unclear to date.This study followed 112 patients with asthma at 3-month intervals for 2 years.to CO and PM2.5 was negatively associated with the large airway function of adults with asthmathan in adults with moderate asthma.Patients with asthma react differently to air pollutants as evidenced by their lung function levels.

Keywords： lung function     asthma     air pollution     adult    

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Not asthma, but GERD: case report

WANG Zhonggao

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 115-119 doi: 10.1007/s11684-007-0022-6

Abstract: Asthma is a disorder of the lungs characterized by increased responsiveness of the airways, as manifestedpatient suffered from GERD without esophageal symptoms, which was diagnosed and treated as bronchial asthmadiagnosis was made and treatment of laporascopic fundaplication was performed, the longstanding bronchial asthmaThe concept of not asthma, but GERD seems undervalued, unappreciated, even misunderstood among patientswith intractable asthma.

Keywords： resistance     mechanism responsible     unappreciated     responsiveness     different    

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Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomized

Ting Liu, Faping Wang, Geng Wang, Hui Mao

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 340-349 doi: 10.1007/s11684-017-0565-0

Abstract: interleukin-5 receptor α to deplete blood eosinophils and improve the clinical outcomes of allergic asthmato evaluate the safety and efficacy of different doses of benralizumab in patients with eosinophilic asthmaAll randomized controlled trials involving benralizumab treatment for patients with eosinophilic asthmapublished until January 2017, as well as the rate of asthmatic exacerbation, pulmonary functionality, asthmas (FEV1), Asthma Quality of Life Questionnaire scores, decreased asthmatic exacerbation and Asthma Control

Keywords： benralizumab     anti-interleukin-5     monoclonal antibody     eosinophilic asthma     meta-analysis    

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A belated revelation: from gastroesophageal reflux derived asthma to laryngotracheal irritation even

WANG Zhonggao

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 127-129 doi: 10.1007/s11684-008-0023-0

Abstract: syndromes: reflux cough syndrome, reflux laryngitis syndrome, reflux dental erosion syndrome and the reflux asthmaThe author himself happened to receive five emergency rescue treatments following apparent “bronchial asthmaThe procedure immediately cleared up his “asthma”.The GER-derived asthma is not asthma, but GER pure and simple;2.The pathogenesis of “asthma” is not asthma, but laryngotracheal irritation/spasm and its sequence.

Keywords： laryngotracheal irritation/spasm     gastro-oesophago-laryngo-tracheal     sequence     fundaplication     encouraging    

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Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study

Siyi Li, Peilin Lv, Min He, Wenjing Zhang, Jieke Liu, Yao Gong, Ting Wang, Qiyong Gong, Yulin Ji, Su Lui

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 792-801 doi: 10.1007/s11684-020-0745-1

Abstract: Asthma is a serious health problem that involves not only the respiratory system but also the centralPrevious studies identified either regional or network alterations in patients with asthma, but inconsistentare the regional and neural network deficits related or are they two independent characteristics in asthmaBy collecting resting-state functional magnetic resonance imaging from 39 patients with asthma and 40network changes, thereby suggesting that the two parameters reflect different brain characteristics of asthma

Keywords： asthma     brain     regional activation     functional connectivity     resting-state fMRI    

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Outcome of Stretta radiofrequency and fundoplication for GERD-related severe asthmatic symptoms

Zhiwei Hu,Jimin Wu,Zhonggao Wang,Yu Zhang,Weitao Liang,Chao Yan

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 437-443 doi: 10.1007/s11684-015-0422-y

Abstract: (GERD) patients with severe asthmatic symptoms who responded inadequately to medical treatment for asthma

Keywords： asthma     gastroesophageal reflux     Stretta radiofrequency     laparoscopic Nissen fundoplication    

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Tim-3 mRNA expression in peripheral blood lymphocytes from asthmatic patients

Xiaoxia LU, Weikun HU, Shengdao XIONG, Guopeng XU, Fen LAN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 187-190 doi: 10.1007/s11684-009-0033-6

Abstract: The expression of Tim-3 mRNA in patients with acute asthma exacerbation was 0.39±0.06, significantlyThe level of IL-4 in patients with acute asthma exacerbation was 68.42±10.54, significantly higher thanThe level of IFN-γ in patients with acute asthma exacerbation was 65.74±7.85, significantly lower thanThe level of IFN-γ in patients in asthma remission was significantly lower than that in controls ( <0.05

Keywords： asthma     airway inflammation     peripheral blood lymphocyte     Tim-3    

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Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle

Zhonggao Wang,Zhiwei Hu,Jimin Wu,Feng Ji,Hongtao Wang,Yungang Lai,Xiang Gao,Yachan Ning,Chengchao Zhang,Zhitong Li,Weitao Liang,Jianjun Liu

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 117-122 doi: 10.1007/s11684-014-0343-1

Abstract:

At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux (GER) insults on our own airway. Symptoms of GER are commonly seen as heartburn and regurgitation, which can be mostly tolerated. However, when the up going gastric content reversely passes the esophagus and then the distal pharynx, where it appears a beak like stricture, serving as a nozzle, so as to produce numerous micro-particles and reach the oro-nasal cavity and also the airway causing allergic rhinitis and asthmatic attacks, even pulmonary parenchyma lesions. It will reduce life quality or even jeopardize life. The point that the endogenous insult appears in the respiratory system, but originates from the digestive tract is not well known and often undiagnosed and not correctly treated. The GER induced airway challenge is a treatable and preventive entity, as soon as a diagnosis is made, a good relief could be expected by means of life style adjustment, medicine, or fixation of the patulous cardia through radiofrequency or fundoplication. The author Dr. Zhonggao Wang had suffered it for long and symptoms disappeared for 8 years after anti-reflux surgery. Here is a presentation of Dr. Zhonggao Wang and his team’s work and would call attention to the public so as to recognize this relatively unknown entity — a treatable condition occurring from human itself, but not from outside surroundings as smoking or haze does.

Keywords： gastroesophageal reflux     airway     pharyngeal nozzle     micro-aspiration     asthma    

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Title Author Date Type Operation

Prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran

Fatemeh Mehravar,Soheil Rafiee,Behnaz Bazrafshan,Mahmoud Khodadost

Journal Article

Lung function and air pollution exposure in adults with asthma in Beijing: a 2-year longitudinal panel

Journal Article

Not asthma, but GERD: case report

WANG Zhonggao

Journal Article

Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomized

Ting Liu, Faping Wang, Geng Wang, Hui Mao

Journal Article

A belated revelation: from gastroesophageal reflux derived asthma to laryngotracheal irritation even

WANG Zhonggao

Journal Article

Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study

Siyi Li, Peilin Lv, Min He, Wenjing Zhang, Jieke Liu, Yao Gong, Ting Wang, Qiyong Gong, Yulin Ji, Su Lui

Journal Article

Outcome of Stretta radiofrequency and fundoplication for GERD-related severe asthmatic symptoms

Zhiwei Hu,Jimin Wu,Zhonggao Wang,Yu Zhang,Weitao Liang,Chao Yan

Journal Article

Tim-3 mRNA expression in peripheral blood lymphocytes from asthmatic patients

Xiaoxia LU, Weikun HU, Shengdao XIONG, Guopeng XU, Fen LAN

Journal Article

Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle

Zhonggao Wang,Zhiwei Hu,Jimin Wu,Feng Ji,Hongtao Wang,Yungang Lai,Xiang Gao,Yachan Ning,Chengchao Zhang,Zhitong Li,Weitao Liang,Jianjun Liu

Journal Article