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lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 317-329 doi: 10.1007/s11684-022-0931-4

Abstract: Moreover, impaired autophagy was observed, as shown by a decreased LC3II/LC3I protein ratio and an elevatedBy contrast, lncR-GAS5 knockdown promoted autophagy.Mechanistically, lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagyFurther results revealed that overexpression of the lncR-GAS5-targeted gene miR-193-5p promoted autophagyIn conclusion, lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10

Keywords: lncR-GAS5     miR-193-5p     splicing factor SRSF10     autophagy     atherogenesis    

Autophagy and the nutritional signaling pathway

Long HE,Shabnam ESLAMFAM,Xi MA,Defa LI

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 3,   Pages 222-230 doi: 10.15302/J-FASE-2016106

Abstract: These include responses to both environmental and physiological changes and autophagy is one of mostAutophagy is defined as an autolytic process to clear damaged cellular organelles and recycle the nutrientsThe process of autophagy responds to special conditions such as nutrient withdrawal.Once autophagy is induced, phagophores form and then elongate and curve to form autophagosomes.The process of autophagy is regulated by autophagy related genes (ATGs).

Keywords: Autophagy     ULK1 complex     VPS34 complex     AMPK     mTOR     nutrient signaling    

Autoimmune regulator regulates autophagy in THP-1 human monocytes

Liang SHI, Li-Hua HU, Yi-Rong LI

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 336-341 doi: 10.1007/s11684-010-0096-4

Abstract: However, the role of AIRE in autophagy in immune cells, especially in monocytes, is obscure.Moreover, an autophagy inhibitor or knockdown of AIRE by small interference RNA attenuated these effectsOur findings indicate that AIRE plays a role in the regulation of autophagy in THP-1 human monocytes.

Keywords: autoimmune regulator     autophagy     monocytes     light chain 3 (LC3)    

Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 538-557 doi: 10.1007/s11684-024-1079-1

Abstract: This study examined how autophagy in HPCs affects schistosomiasis-induced liver fibrosis by modulatingBy coculturing HPCs with hepatic stellate cells (HSCs) and assessing the autophagy level in HPCs by proteomicanalysis and in vitro phenotypic assays, we found that impaired autophagy degradation in theseBlocking autophagy by the autophagy inhibitor chloroquine (CQ) significantly diminished liver fibrosisTargeting the autophagy degradation process may be a therapeutic strategy for liver fibrosis during <

Keywords: schistosomiasis     hepatic progenitor cell     autophagy     extracellular vesicle     fibrosis     miRNA    

The critical role of autophagy in plant responses to abiotic stresses

Yu WANG,Jie ZHOU,Jingquan YU

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 1,   Pages 28-36 doi: 10.15302/J-FASE-2017130

Abstract: Autophagy is an evolutionary conserved recycling process in eukaryotes whereby intracellular componentsIn organisms like yeast and metazoans, autophagy is actively engaged during environmental perturbationStudies over the last decade have also revealed numerous important mechanisms where autophagy is widelyAutophagy serves as a pivotal route for nutrient remobilization by the degradation of superfluous orIn this review, recent advances in our understanding of autophagy, along with pathways and regulatory

Keywords: abiotic stresses     autophagy     extreme temperature     nutrient starvation     osmotic stress     oxidative stress    

Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR

Jun Song, Yeping Huang, Wenjian Zheng, Jing Yan, Min Cheng, Ruxing Zhao, Li Chen, Cheng Hu, Weiping Jia

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 697-706 doi: 10.1007/s11684-018-0655-7

Abstract: Resveratrol also induced endothelial cell autophagy, which mediated the effect of resveratrol on ROSResveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway.Taken together, these data suggest that resveratrol prevents PA-induced intracellular ROS by autophagyThus, the induction of autophagy by resveratrol may provide a novel therapeutic candidate for cardioprotection

Keywords: resveratrol     reactive oxygen species     AMPK     mTOR     autophagy    

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 883-895 doi: 10.1007/s11684-022-0919-0

Abstract: Here, we reported that autophagy was highly activated in metastatic osteosarcoma.We further examined the expression of the autophagy-related genes Beclin1 and LC3B in 82 patients throughMoreover, we demonstrated that autophagy-related genes were activated by SEs and that the inhibitionOverall, our findings highlighted the association of autophagy with osteosarcoma progression and shednew light on autophagy-targeting therapy for osteosarcoma.

Keywords: osteosarcoma     autophagy     metastasis     drug resistance     Beclin1     LC3B    

Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 723-735 doi: 10.1007/s11684-021-0905-y

Abstract: CORO1A overexpression resulted in increased apoptosis and oxidative stress, overactivated autophagy,

Keywords: amyotrophic lateral sclerosis     coronin-1a     autophagy     pathogenesis    

Repurposing Loperamide as an Anti-Infection Drug for the Treatment of Intracellular Bacterial Pathogens

Hongtao Liu,Siqi Li,Le Deng,Zhenxu Shi,Chenxiao Jiang,Jingyan Shu,Yuan Liu,Xuming Deng,Jianfeng Wang,Zhimin Guo,Jiazhang Qiu,

Engineering doi: 10.1016/j.eng.2024.01.011

Abstract: A mechanistic study revealed that the increase in host autophagy and elimination of intracellular bacteria

Keywords: Food and Drug Administration (FDA)-approved drugs     Drug repurposing     Loperamide     Autophagy     Glycoprotein    

Tanshinone IIA Suppresses Non-Small Cell Lung Cancer Through Beclin-1-Mediated Autophagic Apoptosis Article

Shasha Bai, Sainan Cui, Wenhao Wen, Elaine Lai-Han Leung, Jing Bai, Huiyuan Lin, Yongfei Cui, Lei Yang, Zhongqiu Liu, Yuan Zheng, Rong Zhang

Engineering 2022, Volume 19, Issue 12,   Pages 128-138 doi: 10.1016/j.eng.2021.07.014

Abstract: protein (Bax) ratio in human non-small cell lung cancer (NSCLC) cell lines, which was promoted by an autophagyactivator Rapamycin, and weaken by autophagy inhibitor 3-methyladenine (3-MA).

Keywords: Tan IIA     Autophagy     Apoptosis     Beclin-1    

Procyanidin C1 Modulates the Microbiome to Increase FOXO1 Signaling and Valeric Acid Levels to Protect the Mucosal Barrier in Inflammatory Bowel Disease

Xifan Wang,Pengjie Wang,Yixuan Li,Huiyuan Guo,Ran Wang,Siyuan Liu,Ju Qiu,Xiaoyu Wang,Yanling Hao,Yunyi Zhao,Haiping Liao,Zhongju Zou,Josephine Thinwa,Rong Liu,

Engineering doi: 10.1016/j.eng.2023.10.016

Abstract: We also analyzed the autophagy marker LC3 and found that the level of LC3 was significantly elevated

Keywords: Inflammatory bowel disease     Mucosal Barrier     Autophagy    

Title Author Date Type Operation

lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis

Journal Article

Autophagy and the nutritional signaling pathway

Long HE,Shabnam ESLAMFAM,Xi MA,Defa LI

Journal Article

Autoimmune regulator regulates autophagy in THP-1 human monocytes

Liang SHI, Li-Hua HU, Yi-Rong LI

Journal Article

Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis

Journal Article

The critical role of autophagy in plant responses to abiotic stresses

Yu WANG,Jie ZHOU,Jingquan YU

Journal Article

Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR

Jun Song, Yeping Huang, Wenjian Zheng, Jing Yan, Min Cheng, Ruxing Zhao, Li Chen, Cheng Hu, Weiping Jia

Journal Article

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Journal Article

Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target

Journal Article

Repurposing Loperamide as an Anti-Infection Drug for the Treatment of Intracellular Bacterial Pathogens

Hongtao Liu,Siqi Li,Le Deng,Zhenxu Shi,Chenxiao Jiang,Jingyan Shu,Yuan Liu,Xuming Deng,Jianfeng Wang,Zhimin Guo,Jiazhang Qiu,

Journal Article

Tanshinone IIA Suppresses Non-Small Cell Lung Cancer Through Beclin-1-Mediated Autophagic Apoptosis

Shasha Bai, Sainan Cui, Wenhao Wen, Elaine Lai-Han Leung, Jing Bai, Huiyuan Lin, Yongfei Cui, Lei Yang, Zhongqiu Liu, Yuan Zheng, Rong Zhang

Journal Article

Procyanidin C1 Modulates the Microbiome to Increase FOXO1 Signaling and Valeric Acid Levels to Protect the Mucosal Barrier in Inflammatory Bowel Disease

Xifan Wang,Pengjie Wang,Yixuan Li,Huiyuan Guo,Ran Wang,Siyuan Liu,Ju Qiu,Xiaoyu Wang,Yanling Hao,Yunyi Zhao,Haiping Liao,Zhongju Zou,Josephine Thinwa,Rong Liu,

Journal Article