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Phase separation in cGAS-STING signaling

Frontiers of Medicine   Pages 855-866 doi: 10.1007/s11684-023-1026-6

Abstract: separation are widespread and play critical roles in many physiological and pathological processes. cGAS-STINGAt the same time, cGAS-STING signaling must be carefully regulated to maintain immune homeostasis.signaling, including cGAS condensates, STING condensates, and IRF3 condensates.These studies reveal novel activation and regulation mechanisms of cGAS-STING signaling and provide newHere, we summarize recent advances in the phase separation of cGAS-STING signaling and the development

Keywords: biomolecular condensates     phase separation     cGAS-STING pathway     cGAS     STING     cGAMP     interferon    

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Phase separation in cGAS-STING signaling

Journal Article