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Dynamics of foot-and-mouth disease virus replication in cells at different phases of the cell-division

Claudia DOEL,Zhidong ZHANG,Lise MAZELET,Ryan WATERS,John BASHIRUDDIN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3, Pages 250-257 doi: 10.15302/J-FASE-2014031

Abstract: Foot-and-mouth-disease virus (FMDV) replicates in epithelial cells.

Keywords： foot-and-mouth disease virus cell cycle replication

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Review of hand, foot and mouth disease

Lan-Juan LI MD,

Frontiers of Medicine 2010, Volume 4, Issue 2, Pages 139-146 doi: 10.1007/s11684-010-0033-6

Abstract: Hand, foot and mouth disease (HFMD) is an acute viral illness that primarily affects infants and young

Keywords： hand foot and mouth disease epidemiology pathogenesis management surveillance

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Progress on the research and development of human enterovirus 71 (EV71) vaccines

Zhenglun Liang, Qunying Mao, Fan Gao, Junzhi Wang

Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 111-121 doi: 10.1007/s11684-012-0237-z

Abstract:

Enterovirus 71 (EV71) infections, which can cause severe complications, have become one of the serious public health issues in the Western Pacific region and China. To date, a number of pharmaceutical companies and institutes have initiated the research and development of EV71 vaccines as a countermeasure. As is the case with innovative vaccine development, there are several critical bottlenecks in EV71 vaccine development that must be overcome before the clinical trials, including the selection of vaccine strain, standardization of the procedure for quantifying neutralizing antibody (NTAb) and antigen, establishment and application of a reference standard and biological standards, development of animal models for the evaluation of protective efficacy, and identification of the target patient population. To tackle these technical obstacles, researchers in Mainland of China have conducted a series of studies concerning the screening of vaccine strains and the establishment of criteria, biological standards and detection methods, thereby advancing EV71 vaccine development. This review summarizes recent worldwide progress on the quality control and evaluation of EV71 vaccines.

Keywords： enterovirus 71 (EV71) hand foot and mouth disease (HFMD) vaccine

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Mouth the mirror of lungs: where does the connection lie?

Jananni Muthu,Sivaramakrishnan Muthanandam,Jaideep Mahendra

Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 405-409 doi: 10.1007/s11684-016-0476-5

Abstract:

Periodontitis is the chronic destructive disease of the periodontium (Gums) caused by host bacterial

Keywords： periodontitis respiratory diseases acute pneumonia COPD

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Structural synthesis of ancient Chinese foot-operated silk-reeling mechanism

Kuohung HSIAO, Yuhsun CHEN, Hongsen YAN,

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 3, Pages 279-288 doi: 10.1007/s11465-010-0101-2

Abstract: This work synthesizes the structures of the foot-operated silk-reeling mechanism, which was vaguely depicted

Keywords： silk-reeling mechanism structure of mechanism reconstruction design history of machinery

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Planar jumping with stable landing through foot orientation design and ankle joint control

Qilong YUAN, I-Ming CHEN

Frontiers of Mechanical Engineering 2012, Volume 7, Issue 2, Pages 100-108 doi: 10.1007/s11465-012-0318-3

Abstract: In this work, through determining the upper body posture trajectory in the flight phase, the foot landingTogether with properly designing the trajectory for local center of gravity and the foot landing velocity

Keywords： biped jumping stable landing control jumping motion generation

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et’s disease in a Chinese population

Shengping Hou, Aize Kijlstra, Peizeng Yang

Frontiers of Medicine 2012, Volume 6, Issue 4, Pages 354-359 doi: 10.1007/s11684-012-0234-2

Abstract: et’s disease is defined as a multisystemic inflammatory disease.et’s disease. To explore the genetic factors for Beh?et’s disease, our group investigated the association of Beh?et’s disease with multiple immune response genes and has identified multiple Beh?et’s disease-related immunoregulatory pathways in the Chinese Han population.

Keywords： et’s disease SNPs immune gene genetic study

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Minimal residual disease in solid tumors: an overview

Frontiers of Medicine doi: 10.1007/s11684-023-1018-6

Abstract: Minimal residual disease (MRD) is termed as the small numbers of remnant tumor cells in a subset of patients

Keywords： MRD solid tumor CTC ctDNA

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Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 425-432 doi: 10.1007/s11684-013-0295-x

Abstract:

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality

Keywords： chronic obstructive pulmonary disease heterogeneity phenotype genotype prediction

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Acupuncture for the management of dry eye disease

Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 975-983 doi: 10.1007/s11684-022-0923-4

Abstract: The effectiveness of using acupuncture for dry eye disease (DED) is controversial.outcomes of interests were (1) to evaluate the efficacy of acupuncture in improving the ocular surface disease

Keywords： dry eye disease xerophthalmus acupuncture

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Astrocytes in depression and Alzheimer’s disease

Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 829-841 doi: 10.1007/s11684-021-0875-0

Abstract: brain diseases may cause psychosocial and cognitive impairment, such as depression and Alzheimer’s diseasedepression and AD has shown that depression might be a prodrome of progressive degenerative neurological disease

Keywords： astrocytes depression Alzheimer’s disease roles mechanisms

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Exploration of Strategies for Chronic Disease Prevention and Control and Relevant System Development

Long-de Wang

Frontiers of Engineering Management 2015, Volume 2, Issue 1, Pages 2-12 doi: 10.15302/J-FEM-2015002

Abstract: the status of major chronic diseases in China, analyzing the key issues and key factors in chronic diseasethe previous projects, this paper proposes the following recommendations as strategies for chronic diseaseWork norms and requirements will then improve the performance and efficiency in chronic disease prevention

Keywords： chronic disease prevention and control strategy and system construction

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Zooming in and out of ferroptosis in human disease

Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 173-206 doi: 10.1007/s11684-023-0992-z

Abstract: ferroptosis and its regulatory pathways could provide additional strategies for the management of these disease, we summarize the progress in the research into ferroptosis and its regulatory mechanisms in human diseaseWe also discuss our perspectives on the future directions in the targeting of ferroptosis in human disease

Keywords： ferroptosis human disease iron metabolism lipid peroxidation antioxidation

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Multislice computed tomography angiography in the diagnosis of cardiovascular disease: 3D visualizations

Zhonghua Sun

Frontiers of Medicine 2011, Volume 5, Issue 3, Pages 254-270 doi: 10.1007/s11684-011-0153-7

Abstract: computed tomography (CT) has been widely used in clinical practice for the diagnosis of cardiovascular diseaseangiography has been recognized as the method of choice for detecting and diagnosing head and neck vascular diseaseIn patients with suspected coronary artery disease, although invasive coronary angiography still remainsThe imaging diagnosis of cardiovascular disease is based on a combination of two-dimensional (2D) andan overview of the diagnostic performance of various 2D and 3D CT visualizations in cardiovascular disease

Keywords： cardiovascular disease multislice computed tomography three-dimensional reconstruction diagnosis visualization