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Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 112-120 doi: 10.1007/s11705-021-2075-5

Abstract: Notably, these compounds can directly serve as both reporting and imaging agents in vitro and

Keywords： fluorescent drug     lysosomal     anticancer     zebrafish     nude-mouse tumour imaging    

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A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum

Eric C.H. Lai,Kam Man Chung,Stephanie H.Y. Lau,Wan Yee Lau

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 108-111 doi: 10.1007/s11684-014-0344-0

Abstract: developed disseminated intra-abdominal recurrence from a previously resected gastrointestinal stromal tumour

Keywords： gastrointestinal stromal tumour     hemoperitoneum     small bowel GIST     small bowel neoplasm     imatinib    

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Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa

DING Xiaofang, LI Honggang, XIONG Chengliang

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 195-199 doi: 10.1007/s11684-008-0037-7

Abstract: this study is to investigate the chemotactic effect of urokinase-type plasminogen activator (uPA) on mouseFirstly, the chemotactic effect of an ascending gradient of uPA on mouse spermatozoa was observed byMeanwhile, to confirm the specific effect of uPA on mouse sperm chemotaxis, uPA inhibitor (PAI-1) and

Keywords： chemotactic activity     receptor     uPA inhibitor     F10     chemoattractant    

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Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients

Frontiers of Medicine 2023, Volume 17, Issue 6,   Pages 1236-1249 doi: 10.1007/s11684-023-0997-7

Abstract: A Cfap54 knockout mouse model was then reported to have PCD-relevant phenotypes.In addition, a CFAP54 in-frame variant knock-in mouse model was established, which recapitulated

Keywords： primary ciliary dyskinesia     CFAP54     cilia    

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Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 51-57 doi: 10.1007/s11684-008-0010-5

Abstract: SART3) gene can induce antitumor immunity against tumor cells which express the gene, we constructed mouseIt was found that human SART3 DNA vaccine can elicit a specific CTL reaction from the mouse splenocytes

Keywords： antitumor therapy     occurrence     implantation     DNA vaccine     SART3 DNA    

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evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2

Xiaoyan Chen,Wenxia Xiao,Xinchun Li,Jianxun He,Xiaochun Huang,Yuyu Tan

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 471-476 doi: 10.1007/s11684-014-0365-8

Abstract:

This work aims to estimate the value of diffusion weighted imaging (DWI) and diffusion tensor imaging

Keywords： type 2 diabetes mellitus     microalbuminuria     diffusion weighted imaging     diffusion tensor imaging     early-stage    

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Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 919-931 doi: 10.1007/s11684-021-0918-6

Abstract: Preeclampsia (PE) is characterized by placenta-mediated pregnancy complication. The only effective treatment for PE is the delivery of the placenta. However, this treatment may cause preterm birth and neonatal death. Therefore, preventing PE is needed. The mechanism of PE involves abnormal placentation, which leads to the release of anti-angiogenic and inflammatory mediators into maternal circulation. These mediators contribute to systemic vascular dysfunction, inflammatory responses, and excessive thrombin generation. Microparticles (MPs) are reportedly involved in PE by promoting the thromboinflammatory response. This study describes a strategy to prevent PE by reducing MP release using the recombinant protein, diannexin. Results showed that the patients with PE had elevated MP number and procoagulant activity and increased NLRP3 inflammasome activation. Additionally, diannexin remarkably reduced the release of MPs from activated cells by binding to phosphatidylserine exposed on the surface of activated cells. Moreover, in vivo results showed that diannexin could prevent PE-like symptoms by decreasing MPs and NLRP3 inflammasome activation in pregnant mice. Furthermore, diannexin effectively inhibited trophoblast cell activation and NLRP3 inflammasome activation in vitro. These findings suggested that diannexin inhibited MP release and might be an effective therapeutic strategy for preventing PE.

Keywords： preeclampsia     recombinant protein diannexin     microparticle     NLRP3 inflammasome     phosphatidylserin    

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MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus

Lingyan HOU, Yun LU, Ying LI, Li LI

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 1,   Pages 99-105 doi: 10.1007/s11783-013-0490-7

Abstract: test the 17β-estradiol (E2) induced miRNA expression profile at different time points in the immature mouse

Keywords： estrogen     microRNA (miRNA)     microarray     biomarker    

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Spatiotemporal expression of Ezh2 in the developing mouse cochlear sensory epithelium

Yan Chen,Wenyan Li,Wen Li,Renjie Chai,Huawei Li

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 330-335 doi: 10.1007/s11684-016-0459-6

Abstract: However, the detailed expression profile of Ezh2 during mouse cochlear development has not been investigated

Keywords： polycomb repressive complex     Ezh2     expression     inner ear     cochlea     development    

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Molecular dynamic simulation on the conformation of mouse muscle type nAChR

Shengai SUN, Rilei YU, Yanhui ZHANG, Yanni LI,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 3,   Pages 348-352 doi: 10.1007/s11705-009-0284-4

Abstract: A mouse muscle type nAChR model ((α1)βδγ) was built based on the cryoelectron microscopic

Keywords： pentameric     hydrophilic     Tyr127     cryoelectron microscopic     conformation    

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Histone variants: critical determinants in tumour heterogeneity

Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 289-297 doi: 10.1007/s11684-018-0667-3

Abstract: chromatin dynamics could therefore constitute an essential step in driving oncogenesis and in generating tumourreprogramming, histone under-dosage and histone variants should also be crucial in cell transformation and tumourhistone variants in chromatin dynamics and their ability to enhance oncogenic cell reprogramming and tumour

Keywords： cancer-testis     TH2B     TH2A     H1T     H1.0     H1F0     linker histones    

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In vivo imaging of hematopoietic stem cell development in the zebrafish

Panpan Zhang, Feng Liu

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 239-247 doi: 10.1007/s11684-011-0123-0

Abstract: imaging is crucial for developmental biology and can further help to follow cell development/differentiationRecent advances in optical imaging techniques has facilitated tracing of the developmental dynamics ofThe zebrafish is an excellent model for imaging of hematopoiesis due to its transparent embryo at earlyIn this review, we summarize recent studies related to the non-invasive imaging of HSC transgenics,

Keywords： hematopoietic stem cell     hematopoiesis     in vivo imaging     transgenics     zebrafish    

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Carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 3,   Pages 298-306 doi: 10.1007/s11705-022-2212-9

Abstract: Finally, the CA-CDs has been successfully applied for two-photon imaging of the pH in liver and kidneyImaging results showed that the pH value in kidney of diabetic mice was lower than that of the normal

Keywords： carbon dots     two-photon imaging     pH     diabetic mice    

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Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain

Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 141-147 doi: 10.1007/s11684-009-0041-6

Abstract: Rab proteins and their effectors facilitate vesicular transport by tethering donor vesicles to their respective target membranes. Rab9 mediates late endosome-to- -Golgi-network trafficking. To explore the possibility of Rab9-related gene therapy for neurodegenerative diseases, we packed Lentivirus encoding Rab9. The expressing plasmid pCDH1-MCF1-Rab9-EF1-copGFP was constructed by using molecular biological techniques. The Lentivirus encoding Rab9 cDNA was packed by Lifectamine-2000 mediated co-transfection of the plasmid pPACKH1- , pPACKH1- and pVSV- into 293T cells. DNA sequencing proved the successful construction of pCDH1-MCF1-Rab9-EF1-copGFP. After 72 hours, the expression of GFP could be detected in BV-2 cells. Western blotting revealed that the Rab9 gene expression in BALB/c mice brain was up-regulated significantly 4 weeks after injection with Lentivirus encoding Rab9, which evidenced a satisfactory increasing effect of this virus. Administration of Lenti-Rab9 to postnatal day 3 Niemann-Pick disease type C (NPC) mice reduced motor defects and prevented the weight loss associated with female NPC mice, as well as modulating the death rate of Purkinje neurons. It is concluded that the packaging of Lentivirus encoding Rab9 was successful. Lentivirus encoding Rab9 can increase the expression of Rab9 gene effectively, which might offer a novel means for the treatment of neurodegenerative diseases.

Keywords： Rab9     lentivirus     gene therapy     gene transfer    

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Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse

Frontiers of Medicine doi: 10.1007/s11684-024-1095-1

Abstract: Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse

Keywords： Setd2 mutation     activity Setd2 embryonic    

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Title Author Date Type Operation

Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging

Journal Article

A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum

Eric C.H. Lai,Kam Man Chung,Stephanie H.Y. Lau,Wan Yee Lau

Journal Article

Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa

DING Xiaofang, LI Honggang, XIONG Chengliang

Journal Article

Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients

Journal Article

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Journal Article

evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2

Xiaoyan Chen,Wenxia Xiao,Xinchun Li,Jianxun He,Xiaochun Huang,Yuyu Tan

Journal Article

Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing

Journal Article

MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus

Lingyan HOU, Yun LU, Ying LI, Li LI

Journal Article

Spatiotemporal expression of Ezh2 in the developing mouse cochlear sensory epithelium

Yan Chen,Wenyan Li,Wen Li,Renjie Chai,Huawei Li

Journal Article

Molecular dynamic simulation on the conformation of mouse muscle type nAChR

Shengai SUN, Rilei YU, Yanhui ZHANG, Yanni LI,

Journal Article

Histone variants: critical determinants in tumour heterogeneity

Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin

Journal Article

In vivo imaging of hematopoietic stem cell development in the zebrafish

Panpan Zhang, Feng Liu

Journal Article

Carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice

Journal Article

Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain

Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI

Journal Article

Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse

Journal Article