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Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic

Frontiers of Medicine 2024, Volume 18, Issue 2,   Pages 327-343 doi: 10.1007/s11684-023-1022-x

Abstract: Though an altered microenvironment is a general cancer hallmark, how APL blasts shape their plasma compositionnetwork to interpret multilayered datasets on clinical parameters, proteomes, and metabolomes of paired plasmaOur study revealed the two prominent features of the APL plasma, suggesting a possible involvement ofAPL blasts in modulating plasma composition.proteins or enzymes catalyzing plasma-altered metabolites that were potential trans-regulatory

Keywords: acute promyelocytic leukemia     plasma proteomics     plasma metabolomics     cross-sectional correlation network    

Transcriptomics and proteomics in stem cell research

Hai Wang,Qian Zhang,Xiangdong Fang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 433-444 doi: 10.1007/s11684-014-0336-0

Abstract: Multi-omics integrative analysis, such as transcriptomics combined with proteomics, is one of the most

Keywords: embryonic stem cells     transcriptomics     proteomics    

Application of proteomics in environmental science

Xiaona CHU, Jiangyong HU, Say Leong ONG,

Frontiers of Environmental Science & Engineering 2009, Volume 3, Issue 4,   Pages 393-403 doi: 10.1007/s11783-009-0145-x

Abstract: Proteomics involves the separation of proteins, identification of the amino acid sequence of the interested

Keywords: proteomics     environmental stress     two dimensional (2D) gel electrophoresis     mass spectrometry    

Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 429-441 doi: 10.1007/s11684-021-0842-9

Abstract: Quantitative proteomics was employed to investigate the protein expression profiles in iPSCs-transplanted

Keywords: microenvironment     induced pluripotent stem cells (iPSCs)     positron emission tomography (PET)     quantitative proteomics    

Sepsis biomarkers: an omics perspective

Xiao Liu, Hui Ren, Daizhi Peng

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 58-67 doi: 10.1007/s11684-014-0318-2

Abstract: describes currently available and novel sepsis biomarkers in the context of genomics, transcriptomics, proteomics

Keywords: sepsis     biomarker     genomics     transcriptomics     proteomics     metabolomics    

Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

Frontiers of Medicine 2024, Volume 18, Issue 2,   Pages 375-393 doi: 10.1007/s11684-023-1020-z

Abstract: Retroperitoneal liposarcoma (RLPS) is the main subtype of retroperitoneal soft sarcoma (RSTS) and has a poor prognosis and few treatment options, except for surgery. The proteomic and metabolic profiles of RLPS have remained unclear. The aim of our study was to reveal the metabolic profile of RLPS. Here, we performed proteomic analysis (n = 10), metabolomic analysis (n = 51), and lipidomic analysis (n = 50) of retroperitoneal dedifferentiated liposarcoma (RDDLPS) and retroperitoneal well-differentiated liposarcoma (RWDLPS) tissue and paired adjacent adipose tissue obtained during surgery. Data analysis mainly revealed that glycolysis, purine metabolism, pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue, whereas the tricarboxylic acid (TCA) cycle, lipid absorption and synthesis, fatty acid degradation and biosynthesis, as well as glycine, serine, and threonine metabolism were downregulated. Of particular importance, the glycolytic inhibitor 2-deoxy-D-glucose and pentose phosphate pathway (PPP) inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2 inhibitor RG7112 and CDK4 inhibitor abemaciclib. Our study not only describes the metabolic profiles of RDDLPS and RWDLPS, but also offers potential therapeutic targets and strategies for RLPS.

Keywords: RLPS     proteomics     metabolomics     lipidomics     metabolism    

Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 378-388 doi: 10.1007/s11684-021-0840-y

Abstract: this study, serum samples were collected from patients with general MPP (GMPP) and SMPP to conduct proteomicsTo our knowledge, this study was the first proteomics-based characterization of patients with SMPP and

Keywords: severe Mycoplasma pneumoniae pneumonia     children     proteomics     Fc fragment of the IgG-binding protein    

Kinetic Monte Carlo simulations of plasma-surface reactions on heterogeneous surfaces

Daniil Marinov

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 4,   Pages 815-822 doi: 10.1007/s11705-019-1837-9

Abstract: Plasma-surface interactions are complex and relatively poorly understood.performed over the last decade by several groups prove that interactions of reactive species with relevant plasma-facing

Keywords: plasma-surface interaction     kinetic Monte Carlo     plasma nano technology    

Diagnostic evaluation of plasma aldosterone concentration to plasma renin activity ratio in primary aldosteronism

ZHANG Huilan, WANG Daowen

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 11-14 doi: 10.1007/s11684-008-0003-4

Abstract: Using the plasma aldosterone concentration to plasma renin activity ratio (PAC/PRA ratio) as the screeningThe plasma aldosterone concentration (PAC) and plasma renin activity (PRA) levels were measured by radioimmunoassay

Important parameters in plasma jets for the production of RONS in liquids for plasma medicine: A brief

Anna Khlyustova, Cédric Labay, Zdenko Machala, Maria-Pau Ginebra, Cristina Canal

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 2,   Pages 238-252 doi: 10.1007/s11705-019-1801-8

Abstract: Reactive oxygen and nitrogen species (RONS) are among the key factors in plasma medicine.The wide variety of plasma sources hampers comparisons.This review focuses on atmospheric pressure plasma jets as the most studied plasma devices in plasma

Keywords: atmospheric plasma jets     liquids     ROS     RNS     plasma-dose    

Plasma-catalysis: Is it just a question of scale?

J. Christopher Whitehead

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 2,   Pages 264-273 doi: 10.1007/s11705-019-1794-3

Abstract: describing and understanding the changes in performance that result when a catalyst is placed into plasmaphysical interactions that result and how their combination might produce beneficial results for the plasma-catalyticThe focus is on non-thermal plasma where the lack of thermal equilibrium creates a range of temperatureIt is concluded that plasma-catalysis is best regarded as conventional catalysis perturbed by the presenceThe sometimes used description “plasma-activated catalysis” is an apt one.

Keywords: plasma catalysis     plasma-activated catalysis     non-thermal plasma     CO2 conversion    

Identification of transporter proteins for PQQ-secretion pathways by transcriptomics and proteomics analysis

Hui Wan,Yu Xia,Jianghua Li,Zhen Kang,Jingwen Zhou

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 72-88 doi: 10.1007/s11705-016-1580-4

Abstract: Pyrroloquinoline quinone (PQQ) plays a significant role as a redox cofactor in combination with dehydrogenases in bacteria. These dehydrogenases play key roles in the oxidation of important substrates for the biotechnology industry, such as vitamin C production. While biosynthesis of PQQ genes has been widely studied, PQQ-transport mechanisms remain unclear. Herein, we used both two-dimensional fluorescence-difference gel electrophoresis tandem mass spectrometry and RNA sequencing to investigate the effects of overexpression in an industrial strain of WSH-003. We have identified 73 differentially expressed proteins and 99 differentially expressed genes, a majority of which are related to oxidation-reduction and transport processes by gene ontology analysis. We also described several putative candidate effectors that responded to increased PQQ levels resulting from overexpression. Furthermore, quantitative PCR was used to verify five putative PQQ-transport genes among different PQQ producing strains, and the results showed that , and were upregulated in all conditions. Then the three genes were over-expressed in WSH-003 and PQQ production were detected. The results showed that extracellular PQQ of B932_1930 (a transporter) and B932_2186 (an ABC transporter permease) overexpression strains were enhanced by 1.77-fold and 1.67-fold, respectively. The results suggest that the proteins encoded by PqqB, B932_1930 and B932_2186 might enhance the PQQ secretion process.

Keywords: 2D-DIGE     pqqB     pyrroloquinoline quinone     RNA-Seq     Vitamin C    

From plasma to plasmonics: toward sustainable and clean water production through membranes

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 1809-1836 doi: 10.1007/s11705-023-2339-3

Abstract: To mitigate such effects, membranes can be treated through two techniques: plasma treatment (a surfaceThis article showcases plasma- and plasmonic-based treatments in the context of water desalination/purification

Keywords: water treatment     membrane-based process     plasma treatment     plasma polymerization     plasmonic     light-to-heat    

Atomistic simulations of plasma catalytic processes

Erik C. Neyts

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 1,   Pages 145-154 doi: 10.1007/s11705-017-1674-7

Abstract: There is currently a growing interest in the realisation and optimization of hybrid plasma/catalyst systemsIn this contribution, an overview is presented on atomic scale simulations of plasma catalytic processesIn particular, this contribution focusses on plasma-assisted catalyzed carbon nanostructure growth, andplasma catalysis for greenhouse gas conversion.

Keywords: atomic scale simulation     plasma-catalyst    

Modelling and diagnostics of multiple cathodes plasma torch system for plasma spraying

Kirsten BOBZIN, Nazlim BAGCIVAN, Lidong ZHAO, Ivica PETKOVIC, Jochen SCHEIN, Karsten HARTZ-BEHREND, Stefan KIRNER, José-Luis MARQUéS, Günter FORSTER

Frontiers of Mechanical Engineering 2011, Volume 6, Issue 3,   Pages 324-331 doi: 10.1007/s11465-011-0125-2

Abstract: of a multiple-arcs system has significantly improved process stability and coating properties in air plasmacomputed tomography equipment for reconstructing the emissivity and temperature distribution of the plasma

Keywords: plasma spraying     electric arc     three-cathode plasma torch     numerical simulation     computed tomography    

Title Author Date Type Operation

Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic

Journal Article

Transcriptomics and proteomics in stem cell research

Hai Wang,Qian Zhang,Xiangdong Fang

Journal Article

Application of proteomics in environmental science

Xiaona CHU, Jiangyong HU, Say Leong ONG,

Journal Article

Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation

Journal Article

Sepsis biomarkers: an omics perspective

Xiao Liu, Hui Ren, Daizhi Peng

Journal Article

Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

Journal Article

Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Journal Article

Kinetic Monte Carlo simulations of plasma-surface reactions on heterogeneous surfaces

Daniil Marinov

Journal Article

Diagnostic evaluation of plasma aldosterone concentration to plasma renin activity ratio in primary aldosteronism

ZHANG Huilan, WANG Daowen

Journal Article

Important parameters in plasma jets for the production of RONS in liquids for plasma medicine: A brief

Anna Khlyustova, Cédric Labay, Zdenko Machala, Maria-Pau Ginebra, Cristina Canal

Journal Article

Plasma-catalysis: Is it just a question of scale?

J. Christopher Whitehead

Journal Article

Identification of transporter proteins for PQQ-secretion pathways by transcriptomics and proteomics analysis

Hui Wan,Yu Xia,Jianghua Li,Zhen Kang,Jingwen Zhou

Journal Article

From plasma to plasmonics: toward sustainable and clean water production through membranes

Journal Article

Atomistic simulations of plasma catalytic processes

Erik C. Neyts

Journal Article

Modelling and diagnostics of multiple cathodes plasma torch system for plasma spraying

Kirsten BOBZIN, Nazlim BAGCIVAN, Lidong ZHAO, Ivica PETKOVIC, Jochen SCHEIN, Karsten HARTZ-BEHREND, Stefan KIRNER, José-Luis MARQUéS, Günter FORSTER

Journal Article