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Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth

Frontiers of Medicine   Pages 873-882 doi: 10.1007/s11684-022-0925-2

Abstract: Tumstatin is a tumor-specific angiogenesis inhibitor that suppresses the proliferation and induces theIn this study, a novel Salmonella-mediated targeted expression system of tumstatin (VNP-Tum5)This study is the first to use tumstatin-transformed VNP20009 as a tumor-targeted system for treatment

Keywords： Salmonella VNP20009     tumstatin     B16F10     melanoma     apoptosis     angiogenesis    

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Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth

Journal Article