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SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and Article

Wei Chen, Peng Yuan, Ming Yang, Zhiqiang Yan, Siming Kong, Jie Yan, Xixi Liu, Yidong Chen, Jie Qiao, Liying Yan

Engineering 2020, Volume 6, Issue 10,   Pages 1162-1169 doi: 10.1016/j.eng.2020.07.013

Abstract: Angiotensin-converting enzyme 2 (ACE2) is the receptor of both severe acute respiratory syndrome coronavirusIn order to investigate the potential risk of SARS-CoV-2 vertical transmission, we explored ACE2extravillous trophoblast (EVTs_24W) cells in the maternal–fetal interface, strongly co-expressed ACE2ACE2 showed no gender bias in post-implantation embryos but showed a significant gender differencein D6 TE, D6 primitive endoderms (PE), and ACE2 positive-expressing STB cells.

Keywords： SARS-CoV-2     ACE2     Vertical transmission     Placenta     Peri-implantation    

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Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different

Xin Zou, Ke Chen, Jiawei Zou, Peiyi Han, Jie Hao, Zeguang Han

Frontiers of Medicine 2024, Volume 18, Issue 1,   Pages 185-192 doi: 10.1007/s11684-020-0754-0

Abstract: originated from Wuhan (China), invades human cells via the receptor angiotensin converting enzyme II (ACE2Moreover, lung cells that have ACE2 expression may be the main target cells during 2019-nCoV infectionesophagus, kidney, bladder, and ileum, and located specific cell types (i.e., type II alveolar cells (AT2)

Keywords： 2019-nCoV     ACE2     single-cell RNA-seq    

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Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells

Guizhen Wang, Qun Zhao, Hui Zhang, Fan Liang, Chen Zhang, Jun Wang, Zhenyin Chen, Ran Wu, Hong Yu, Beibei Sun, Hua Guo, Ruie Feng, Kaifeng Xu, Guangbiao Zhou

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 252-263 doi: 10.1007/s11684-021-0837-6

Abstract: that cigarette smoke extract (CSE) and carcinogen benzo(a)pyrene (BaP) increase mRNA but trigger ACE2for ACE2 ubiquitination.ACE2 in lung tissues of non-smokers is higher than in smokers, consistent with the findings that tobaccocarcinogens downregulate ACE2 in mice.Tobacco carcinogens inhibit SARS-CoV-2 spike protein pseudovirions infection of the cells.

Keywords： SARS-CoV-2     tobacco smoke     benzo(a)pyrene     ACE2     Skp2    

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Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Article

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Engineering 2021, Volume 7, Issue 10,   Pages 1441-1451 doi: 10.1016/j.eng.2020.07.014

Abstract: All seven glycosylation sites in human angiotensin I converting enzyme 2 (hACE2) were found to be completelyglycosylation did not directly contribute to the binding affinity between HCoV-19 S protein and hACE2.including multiple methylated sites in both proteins and multiple sites with hydroxylproline in hACE2.Refined structural models of HCoV-19 S protein and hACE2 were built by adding N-glycan and PTMsThe PTM and glycan maps of HCoV-19 S protein and hACE2 provide additional structural details for studying

Keywords： N-glycosylation     COVID-19     Spike protein     hACE2     Structure    

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Study on neutron cross-section library generated for MCNP in in-hospital neutron irradiator mark 1 reactor

Wang Lipeng,Jiang Xinbiao,Zhao Zhumin,Zhu Yangni,Chen Lixin,Zhou Yongmao

Strategic Study of CAE 2012, Volume 14, Issue 8,   Pages 42-46

Abstract: Accounting for the temperature range for reactor operation, a compact ENDF (ACE) data library was createdThe results showed that the ACE format library produced in this paper was correct and could be used reliably

Keywords： NJOY     ENDF/B VII.0     MCNP     ACE format    

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Fire Risk Evaluation for Historic Building of The Potala Pal ace

Zhuang Lei,Lu Shouxiang,Wang Fuliang

Strategic Study of CAE 2007, Volume 9, Issue 3,   Pages 76-81

Abstract:

The Potala Palace was built in the7th century and it is famous for its great historic and cultural values. From the aspects of fire resource, equipment of fire fighting, evacuation of people and management of fire safety, the situation of fire hazard was investigated in detail. It is necessary to have an efficient approach to evaluate older buildings of significant historic values. Fire risk evaluation described in this paper is one kind of semi-quantitative methods. It uses a model of multiple attribute evaluation to produce a measure of relative fire risk. Weights are established to indicate the importance of fire risk parameters. Then, for each specific historic structure, parameter grades, i.e. ,the amount or degree that a parameter is present, are determined from information collected in the actual situation of the survey. Fire risk is evaluated by the scalar product of the parameter weights and grades, producing a single numerical value representing the level of fire safety provided in the building. Moreover, suggestions are given about fire prevention and protection.

Keywords： the Potala Palace     historical buildings     fire risk assessment     semi-quantitative methods     firehazard    

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第三届环境、工业和能源工程国际会议(EI2E 2019)

Conference Date: 19 Sep 2019

Conference Place: 宁夏银川

Administered by: APISE

第四届设计、机械和材料工程国际会议(D2ME 2019)

Conference Date: 26 Sep 2019

Conference Place: 釜山，韩国

Administered by: HKSME

第四届设计、机械和材料工程国际会议(D2ME 2019)

Conference Date: 26 Sep 2019

Conference Place: 釜山，韩国

Administered by: HKSME

Title Author Date Type Operation

SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and

Wei Chen, Peng Yuan, Ming Yang, Zhiqiang Yan, Siming Kong, Jie Yan, Xixi Liu, Yidong Chen, Jie Qiao, Liying Yan

Journal Article

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different

Xin Zou, Ke Chen, Jiawei Zou, Peiyi Han, Jie Hao, Zeguang Han

Journal Article

Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells

Guizhen Wang, Qun Zhao, Hui Zhang, Fan Liang, Chen Zhang, Jun Wang, Zhenyin Chen, Ran Wu, Hong Yu, Beibei Sun, Hua Guo, Ruie Feng, Kaifeng Xu, Guangbiao Zhou

Journal Article

Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Journal Article

Study on neutron cross-section library generated for MCNP in in-hospital neutron irradiator mark 1 reactor

Wang Lipeng,Jiang Xinbiao,Zhao Zhumin,Zhu Yangni,Chen Lixin,Zhou Yongmao

Journal Article

Fire Risk Evaluation for Historic Building of The Potala Pal ace

Zhuang Lei,Lu Shouxiang,Wang Fuliang

Journal Article

第三届环境、工业和能源工程国际会议(EI2E 2019)

19 Sep 2019

Conference Information

第四届设计、机械和材料工程国际会议(D2ME 2019)

26 Sep 2019

Conference Information

Xiao Yonghong: Co-evolution of Clinical Highly Resistant and Highly Toxic Pathogens (2023-2-22)

10 Mar 2023

Conference Videos

第四届设计、机械和材料工程国际会议(D2ME 2019)

26 Sep 2019

Conference Information

Between Physical Activity, Sedentary Behavior and Cardiovascular Disease risk in Patients with Type 2Diabetes: MlDiab Study (2023-2-21)

2 Mar 2023

Conference Videos

Shenshizhao: Large Span Structure (2018-6-2)

22 Apr 2021

Conference Videos

Jian Li：iScience and Interdisciplinary Research (2020-4-2)

18 Apr 2022

Conference Videos

Jin Yong: Expansion of Chemical Reaction Scale (2018-6-2)

22 Apr 2021

Conference Videos

Academician Xu Mi Interpretation of China's Nuclear Energy (2018-6-2)

22 Apr 2021

Conference Videos