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Journal Article 1

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2015 1

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AET 1

genomic instability 1

mitomycin C 1

rabbit VX2 liver tumor 1

stem-like cancer cells 1

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Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 57-62 doi: 10.1007/s11684-015-0389-8

Abstract: In this study, to block the emergence of SLCCs, aminoethyl isothiourea (AET), a compound that clearsalone increased lung metastases and disadvantaged survival outcome, but the combination of MMC and AETmice, MMC alone enriched tumor-initiating cells, but the administration of MMC in combination with AETFurthermore, MMC alone enhanced genomic instability, but MMC combined with AET attenuated the extentthis combination treatment by AET and cytotoxic agents should be considered as a promising strategy

Keywords： rabbit VX2 liver tumor     mitomycin C     AET     stem-like cancer cells     genomic instability    

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Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Journal Article