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Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 126-135 doi: 10.1007/s11684-020-0767-8

Abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoVAs disease progressed, a series of complications tend to develop, especially in critically ill patients

Keywords： coronavirus disease 2019     epidemiology     pathology     radiology     clinical characteristics     treatment    

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Clinical characteristics of 19 neonates born to mothers with COVID-19

Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, Zhihui Rong

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 193-198 doi: 10.1007/s11684-020-0772-y

Abstract: The aim of this study was to investigate the clinical characteristics of neonates born to SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19. Nineteen neonates were admitted to Tongji Hospital from January 31 to February 29, 2020. Their mothers were clinically diagnosed or laboratory-confirmed with COVID-19. We prospectively collected and analyzed data of mothers and infants. There are 19 neonates included in the research. Among them, 10 mothers were confirmed COVID-19 by positive SARS-CoV-2 RT-PCR in throat swab, and 9 mothers were clinically diagnosed with COVID-19. Delivery occurred in an isolation room and neonates were immediately separated from the mothers and isolated for at least 14 days. No fetal distress was found. Gestational age of the neonates was 38.6±1.5 weeks, and average birth weight was 3293±425 g. SARS-CoV-2 RT-PCR in throat swab, urine, and feces of all neonates were negative. SARS-CoV-2 RT-PCR in breast milk and amniotic fluid was negative too. None of the neonates developed clinical, radiologic, hematologic, or biochemical evidence of COVID-19. No vertical transmission of SARS-CoV-2 and no perinatal complications in the third trimester were found in our study. The delivery should occur in isolation and neonates should be separated from the infected mothers and care givers.

Keywords： coronavirus disease 2019     severe acute respiratory syndrome-associated coronavirus     maternal-infant infection    

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Mesenchymal Stem Cells Represent a Therapeutic Option for Coronavirus Disease 2019-Related Acute Respiratory

Xuan Zhao, Yi Zhang

Engineering 2020, Volume 6, Issue 10,   Pages 1073-1075 doi: 10.1016/j.eng.2020.05.015

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2019 novel coronavirus outbreak: a quiz or final exam?

Jiuyang Xu, Yijun Chen, Hao Chen, Bin Cao

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 225-228 doi: 10.1007/s11684-020-0753-1

Abstract: The 2019 novel coronavirus (2019-nCoV) is an emerging pathogen and is threatening the global health.Strikingly, more than 28 000 cases and 550 deaths have been reported within two months from disease emergenceclinicians, scientists, officials, and citizens in China are all contributing to the prevention of further 2019Efficient preliminary work has enabled us to understand the basic characteristics of 2019-nCoV, but there

Keywords： 2019-nCoV     novel coronavirus     epidemic     public response    

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Organ function support in patients with coronavirus disease 2019: Tongji experience

Yong Li, Fan He, Ning Zhou, Jia Wei, Zeyang Ding, Luyun Wang, Peng Chen, Shuiming Guo, Binhao Zhang, Xiaoning Wan, Wei Zhu, on behalf of Multidisciplinary Team for COVID-19, Optical Valley Branch of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 232-248 doi: 10.1007/s11684-020-0774-9

Abstract: Coronavirus disease 2019 (COVID-19) is a highly contagious disease and a serious threat to human health

Keywords： COVID-19     severe and critical type     organ function support    

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Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19

Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 776-785 doi: 10.1007/s11684-020-0820-7

Abstract: Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus

Keywords： coronavirus disease 2019     pediatrics     emergency     retrospective investigation     severe acute respiratory syndromecoronavirus 2    

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Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019

Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 752-759 doi: 10.1007/s11684-020-0813-6

Abstract: study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical coronavirusdisease 2019 (COVID-19).

Keywords： COVID-19     CHM     mortality     a retrospective cohort study    

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Phase- and epidemic region-adjusted estimation of the number of coronavirus disease 2019 cases in China

Ruijie Chang, Huwen Wang, Shuxian Zhang, Zezhou Wang, Yinqiao Dong, Lhakpa Tsamlag, Xiaoyue Yu, Chen Xu, Yuelin Yu, Rusi Long, Ning-Ning Liu, Qiao Chu, Ying Wang, Gang Xu, Tian Shen, Suping Wang, Xiaobei Deng, Jinyan Huang, Xinxin Zhang, Hui Wang, Yong Cai

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 199-209 doi: 10.1007/s11684-020-0768-7

Abstract: The outbreak of the coronavirus disease 2019 was first reported in Wuhan in December 2019 and gradually

Keywords： SEIR model     COVID-19     estimate     China    

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The East–West Divide in Response to COVID-19 Article

Dean T Jamison, Kin Bing Wu

Engineering 2021, Volume 7, Issue 7,   Pages 936-947 doi: 10.1016/j.eng.2021.05.008

Abstract:

Coronavirus disease 2019 (COVID-19) deaths per million population in the countries of the West hadrsquo;s lockdown of Wuhan on 23 January 2020 provided a final, decisive signal of the danger of the new diseasethe critical month of February 2020 in the United States and most other Western countries allowed the disease

Keywords： Coronavirus disease 2019     Isolation     Non-pharmaceutical interventions     Pandemic     Vaccination    

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A Deep Learning System to Screen Novel Coronavirus Disease 2019 Pneumonia Article

Xiaowei Xu, Xiangao Jiang, Chunlian Ma, Peng Du, Xukun Li, Shuangzhi Lv, Liang Yu, Qin Ni, Yanfei Chen, Junwei Su, Guanjing Lang, Yongtao Li, Hong Zhao, Jun Liu, Kaijin Xu, Lingxiang Ruan, Jifang Sheng, Yunqing Qiu, Wei Wu, Tingbo Liang, Lanjuan Li

Engineering 2020, Volume 6, Issue 10,   Pages 1122-1129 doi: 10.1016/j.eng.2020.04.010

Abstract: viral RNA from sputum or nasopharyngeal swab had a relatively low positive rate in the early stage of coronavirusdisease 2019 (COVID-19).

Keywords： Coronavirus disease 2019 pneumonia     COVID-19     Location-attention classification model     Computed tomography    

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Strategies and Advances in Combating COVID-19 in China Review

Wei Liu, Wei-Jie Guan, Nan-Shan Zhong

Engineering 2020, Volume 6, Issue 10,   Pages 1076-1084 doi: 10.1016/j.eng.2020.10.003

Abstract:

Coronavirus disease 2019 (COVID-19)—the third in a series of coronavirus infections—has

Keywords： Coronavirus disease 2019     Angiotensin-converting enzyme     Immune response     Inflammation     Clinical characteristics    

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Efficacy and Safety of Triazavirin Therapy for Coronavirus Disease 2019: A Pilot Randomized Controlled Article

Xiaoke Wu, Kaijiang Yu, Yongchen Wang, Wanhai Xu, Hongli Ma, Yan Hou, Yue Li, Benzhi Cai, Liying Zhu, Min Zhang, Xiaoli Hu, Jingshu Gao, Yu Wang, Huichao Qin, Wenjie Wang, Mingyan Zhao, Xia Wu, Yong Zhang, Lu Li, Kang Li, Zhimin Du, Ben Willem J. Mol, Baofeng Yang

Engineering 2020, Volume 6, Issue 10,   Pages 1185-1191 doi: 10.1016/j.eng.2020.08.011

Abstract: Roman","serif"">No therapeutics have been proven effective yet for the treatment of coronavirusdisease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Keywords： Coronavirus disease 2019     Triazavirin     Efficacy     Safety    

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The Scientific Foundation of Chinese Herbal Medicine against COVID-19 Perspective

Elaine Lai-Han Leung, Hu-Dan Pan, Yu-Feng Huang, Xing-Xing Fan, Wan-Ying Wang, Fang He, Jun Cai, Hua Zhou, Liang Liu

Engineering 2020, Volume 6, Issue 10,   Pages 1099-1107 doi: 10.1016/j.eng.2020.08.009

Abstract: text-autospace:none">The recent coronavirusdisease 2019 (COVID-19) pandemic outbreak has caused a serious global health emergency.-19 shares a genomic similarity with other coronaviruses, such as severe acute respiratory syndrome coronavirus(SARS-CoV) and Middle East respiratory syndrome  coronavirus (MERS-CoV), and that the pathogenesisTherefore, early prevention of disease progression is important.

Keywords： Coronavirus disease 2019     Severe acute respiratory syndrome coronavirus     Chinese herbal medicine     Antiviral    

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COVID-19 containment: China provides important lessons for global response

Shuxian Zhang, Zezhou Wang, Ruijie Chang, Huwen Wang, Chen Xu, Xiaoyue Yu, Lhakpa Tsamlag, Yinqiao Dong, Hui Wang, Yong Cai

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 215-219 doi: 10.1007/s11684-020-0766-9

Abstract: The world must act fast to contain wider international spread of the epidemic of COVID-19 now. The unprecedented public health efforts in China have contained the spread of this new virus. Measures taken in China are currently proven to reduce human-to-human transmission successfully. We summarized the effective intervention and prevention measures in the fields of public health response, clinical management, and research development in China, which may provide vital lessons for the global response. It is really important to take collaborative actions now to save more lives from the pandemic of COVID-19.

Keywords： coronavirus disease 2019 (COVID-19)     control measure     public health response    

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Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID) Article

Xinyao Jin, Bo Pang, Junhua Zhang, Qingquan Liu, Zhongqi Yang, Jihong Feng, Xuezheng Liu, Lei Zhang, Baohe Wang, Yuhong Huang, Alice Josephine Fauci, Yuling Ma, Myeong Soo Lee, Wei’an Yuan, Yanming Xie, Jianyuan Tang, Rui Gao, Liang Du, Shuo Zhang, Hanmei Qi, Yu Sun, Wenke Zheng, Fengwen Yang, Huizi Chua, Keyi Wang, Yi Ou, Ming Huang, Yan Zhu, Jiajie Yu, Jinhui Tian, Min Zhao, Jingqing Hu, Chen Yao, Youping Li, Boli Zhang

Engineering 2020, Volume 6, Issue 10,   Pages 1147-1152 doi: 10.1016/j.eng.2020.03.002

Abstract:

Since its outbreak in December 2019, a series of clinical trials on coronavirus disease 2019 (COVIDThe COS-COVID includes one outcome for the mild type (time to 2019 novel coronavirus (2019-nCoV) reversethe ordinary type (length of hospital stay, composite events, score of clinical symptoms, and time to 2019sub>)/fraction of inspired oxygen (FiO2), duration of mechanical ventilation, and time to 2019

Keywords： Novel coronavirus pneumonia     Core outcome set     COVID-19     2019-nCoV     Coronavirus disease     Clinical trials    

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Title Author Date Type Operation

Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Journal Article

Clinical characteristics of 19 neonates born to mothers with COVID-19

Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, Zhihui Rong

Journal Article

Mesenchymal Stem Cells Represent a Therapeutic Option for Coronavirus Disease 2019-Related Acute Respiratory

Xuan Zhao, Yi Zhang

Journal Article

2019 novel coronavirus outbreak: a quiz or final exam?

Jiuyang Xu, Yijun Chen, Hao Chen, Bin Cao

Journal Article

Organ function support in patients with coronavirus disease 2019: Tongji experience

Yong Li, Fan He, Ning Zhou, Jia Wei, Zeyang Ding, Luyun Wang, Peng Chen, Shuiming Guo, Binhao Zhang, Xiaoning Wan, Wei Zhu, on behalf of Multidisciplinary Team for COVID-19, Optical Valley Branch of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China

Journal Article

Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19

Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li

Journal Article

Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019

Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong

Journal Article

Phase- and epidemic region-adjusted estimation of the number of coronavirus disease 2019 cases in China

Ruijie Chang, Huwen Wang, Shuxian Zhang, Zezhou Wang, Yinqiao Dong, Lhakpa Tsamlag, Xiaoyue Yu, Chen Xu, Yuelin Yu, Rusi Long, Ning-Ning Liu, Qiao Chu, Ying Wang, Gang Xu, Tian Shen, Suping Wang, Xiaobei Deng, Jinyan Huang, Xinxin Zhang, Hui Wang, Yong Cai

Journal Article

The East–West Divide in Response to COVID-19

Dean T Jamison, Kin Bing Wu

Journal Article

A Deep Learning System to Screen Novel Coronavirus Disease 2019 Pneumonia

Xiaowei Xu, Xiangao Jiang, Chunlian Ma, Peng Du, Xukun Li, Shuangzhi Lv, Liang Yu, Qin Ni, Yanfei Chen, Junwei Su, Guanjing Lang, Yongtao Li, Hong Zhao, Jun Liu, Kaijin Xu, Lingxiang Ruan, Jifang Sheng, Yunqing Qiu, Wei Wu, Tingbo Liang, Lanjuan Li

Journal Article

Strategies and Advances in Combating COVID-19 in China

Wei Liu, Wei-Jie Guan, Nan-Shan Zhong

Journal Article

Efficacy and Safety of Triazavirin Therapy for Coronavirus Disease 2019: A Pilot Randomized Controlled

Xiaoke Wu, Kaijiang Yu, Yongchen Wang, Wanhai Xu, Hongli Ma, Yan Hou, Yue Li, Benzhi Cai, Liying Zhu, Min Zhang, Xiaoli Hu, Jingshu Gao, Yu Wang, Huichao Qin, Wenjie Wang, Mingyan Zhao, Xia Wu, Yong Zhang, Lu Li, Kang Li, Zhimin Du, Ben Willem J. Mol, Baofeng Yang

Journal Article

The Scientific Foundation of Chinese Herbal Medicine against COVID-19

Elaine Lai-Han Leung, Hu-Dan Pan, Yu-Feng Huang, Xing-Xing Fan, Wan-Ying Wang, Fang He, Jun Cai, Hua Zhou, Liang Liu

Journal Article

COVID-19 containment: China provides important lessons for global response

Shuxian Zhang, Zezhou Wang, Ruijie Chang, Huwen Wang, Chen Xu, Xiaoyue Yu, Lhakpa Tsamlag, Yinqiao Dong, Hui Wang, Yong Cai

Journal Article

Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID)

Xinyao Jin, Bo Pang, Junhua Zhang, Qingquan Liu, Zhongqi Yang, Jihong Feng, Xuezheng Liu, Lei Zhang, Baohe Wang, Yuhong Huang, Alice Josephine Fauci, Yuling Ma, Myeong Soo Lee, Wei’an Yuan, Yanming Xie, Jianyuan Tang, Rui Gao, Liang Du, Shuo Zhang, Hanmei Qi, Yu Sun, Wenke Zheng, Fengwen Yang, Huizi Chua, Keyi Wang, Yi Ou, Ming Huang, Yan Zhu, Jiajie Yu, Jinhui Tian, Min Zhao, Jingqing Hu, Chen Yao, Youping Li, Boli Zhang

Journal Article