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Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors
Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 701-713 doi: 10.1007/s11684-022-0951-0
Keywords: acquired resistance EGFR inhibitor apoptosis lung cancer
Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors
Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu
Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 383-388 doi: 10.1007/s11684-016-0488-1
The tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) are becoming theAcquired mutations in EGFR account for one of the major mechanisms of resistance toThree generations of EGFR TKIs have been used in clinical applications.The mechanisms of resistance to third-generation inhibitors reported to date include the EGFRas the latest development of EAI045 as a fourth-generation EGFR inhibitor.
Keywords: EGFR tyrosine kinase inhibitor AZD9291 EAI045
Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12
Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 83-93 doi: 10.1007/s11684-019-0682-z
Keywords: S492R EGFR ectodomain mutation colorectal cancer mAb CH12 immunnotherapy
LI Yanhua, BI Zhigang
Frontiers of Medicine 2007, Volume 1, Issue 1, Pages 79-86 doi: 10.1007/s11684-007-0016-4
CD47 blockade improves the therapeutic effect of osimertinib in non-small cell lung cancer
Frontiers of Medicine 2023, Volume 17, Issue 1, Pages 105-118 doi: 10.1007/s11684-022-0934-1
Keywords: osimertinib anti-CD47 antibody combination strategy ADCP EGFR
Title Author Date Type Operation
Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors
Journal Article
Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors
Shuhang Wang,Yongping Song,Feifei Yan,Delong Liu
Journal Article
Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12
Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang
Journal Article
Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K
LI Yanhua, BI Zhigang
Journal Article