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Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa

DING Xiaofang, LI Honggang, XIONG Chengliang

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 195-199 doi: 10.1007/s11684-008-0037-7

Abstract: counting the number of spermatozoa that migrated into the capillary after incubation with uPA for 5, 10, 20, and 30 min, respectively, compared with that after incubation with F10.rabbit IgG may affect sperm accumulation nonspecifically, PAI-1 and anti-uPAR rabbit IgG were added to F10

Keywords： chemotactic activity     receptor     uPA inhibitor     F10     chemoattractant    

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Effect of process parameters on the density and porosity of laser melted AlSi10Mg/SiC metal matrix composite

FAMODIMU, Mark STANFORD, Chike F. ODUOZA, Lijuan ZHANG

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 4,   Pages 520-527 doi: 10.1007/s11465-018-0521-y

Abstract:

Laser melting of aluminium alloy—AlSi10Mg has increasingly been used to create specialised productsThis included single track formations of the matrix alloy and the composite alloyed with 5% and 10% respectively

Keywords： selective laser melting     additive manufacturing     mechanical alloying     powder metallurgy     aluminium metal matrix composite    

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Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 873-882 doi: 10.1007/s11684-022-0925-2

Abstract: Treatment with VNP-Tum5 effectively suppressed tumor growth and prolonged survival in the mouse model of B16F10exhibited a higher efficacy in inhibiting the proliferation and inducing the necrosis and apoptosis of B16F10

Keywords： Salmonella VNP20009     tumstatin     B16F10     melanoma     apoptosis     angiogenesis    

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PM10 emissions from industrial coal-fired chain-grate boilers

Xinghua Li, Junzan Han, Lei Duan

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 6, doi: 10.1007/s11783-017-0966-y

Abstract: The PM in the submicron mode for burning with raw coal contributes to 33%±10 % of PM emissions, much

Keywords： coal-fired chain-grate boiler     PM10     size distribution     particulate emission control devices    

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Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Frontiers of Medicine   Pages 957-971 doi: 10.1007/s11684-023-0988-8

Abstract: Dynein axonemal heavy chain 10 (DNAH10) encodes a subunit of the inner arm dynein heavy chainBased on the common axoneme structure of motile cilia and sperm flagella, DNAH10 variants areUsing exome sequencing, we identified a novel DNAH10 homozygous variant (c.589C > T, p.R197W)Immunostaining analysis showed the absence of DNAH10 and DNALI1 in the respiratory ciliaSubsequently, animal models of Dnah10-knockin mice harboring missense variants and Dnah10

Keywords： DNAH10     mice     motile cilia     mutation     primary ciliary dyskinesia    

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Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibitspublic databases containing 64 517 patients of 33 cancer types, we found that the expression of Siglec10In particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRCIn 131 KIRC patients of our settings, Siglec10 was elevated in the tumor tissues of 83 (63.4%) patientsMoreover, higher level of Siglec10 was associated with advanced disease (stages III and IV) and worse

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

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The most influential “Top 10 Events” in carbon neutrality and climate change in 2022

Frontiers in Energy 2023, Volume 17, Issue 1,   Pages 1-4 doi: 10.1007/s11708-023-0869-5

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Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 298-302 doi: 10.1007/s11684-008-0057-3

Abstract: In this study the effects of lipopolysaccharide (LPS) and interleukin-10 (IL-10) on the formation ofThe cells were further stimulated by ox-LDL, ox-LDL plus LPS, ox-LDL plus IL-10 and LPS.However, the significant elevation by LPS was abrogated when IL-10 was added.IL-10, an anti-inflammatory cytokine, can inhibit the effect of ox-LDL and LPS.The inhibitive effect of IL-10 is an important factor for delaying atherosclerosis processes.

Keywords： inflammatory     presence     interleukin-10     dose-dependent     ox-LDL    

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Preface of special issue of the 10 th International Conference on CO 2 Utilization

Changjun LIU,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 2,   Pages 109-109 doi: 10.1007/s11705-009-0258-6

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Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 969-974 doi: 10.1007/s11684-021-0912-z

Abstract: A cross-sectional study was conducted among 2–10-year-old children in Sokoto, in August and Decemberto determine the endemicity of malaria based on Plasmodium falciparum prevalence rate (PfPR2-10higher than expected (2.6%), considering the endemicity pattern which was mesoendemic based on a PfPR2-10

Keywords： severe malaria     nigeria     malaria mortality     PfPR2-10     intermediate malaria transmission    

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GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 2,   Pages 309-311 doi: 10.15302/J-FASE-2022440

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Pressure drop analysis on the positive half-cell of a cerium redox flow battery using computational fluid dynamics: Mathematical and modelling aspects of porous media

Fernando F. Rivera, Berenice Miranda-Alcántara, Germán Orozco, Carlos Ponce de León, Luis F. Arenas

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 2,   Pages 399-409 doi: 10.1007/s11705-020-1934-9

Abstract: Description of electrolyte fluid dynamics in the electrode compartments by mathematical models can be a powerful tool in the development of redox flow batteries (RFBs) and other electrochemical reactors. In order to determine their predictive capability, turbulent Reynolds-averaged Navier-Stokes (RANS) and free flow plus porous media (Brinkman) models were applied to compute local fluid velocities taking place in a rectangular channel electrochemical flow cell used as the positive half-cell of a cerium-based RFB for laboratory studies. Two different platinized titanium electrodes were considered, a plate plus a turbulence promoter and an expanded metal mesh. Calculated pressure drop was validated against experimental data obtained with typical cerium electrolytes. It was found that the pressure drop values were better described by the RANS approach, whereas the validity of Brinkman equations was strongly dependent on porosity and permeability values of the porous media.

Keywords： CFD simulation     porous media     porous electrode     pressure drop     redox flow battery    

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Development of soft kernel durum wheat

Craig F. MORRIS

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 3,   Pages 273-278 doi: 10.15302/J-FASE-2019259

Abstract:

Kernel texture (grain hardness) is a fundamental and determining factor related to wheat ( spp.) milling, baking and flour utilization. There are three kernel texture classes in wheat: soft and hard hexaploid ( ), and very hard durum ( subsp. ). The genetic basis for these three classes lies with the Puroindoline genes. Phenotypically, the easiest means of quantifying kernel texture is with the Single Kernel Characterization System (SKCS), although other means are valid and can provide fundamental material properties. Typical SKCS values for soft wheat would be around 25 and for durum wheat≥80. Soft kernel durum wheat was created via homeologous recombination using the mutation, which facilitated the transfer of ca. 28 Mbp of 5DS that replaced ca. 21 Mbp of 5BS. The 5DS translocation contained a complete and intact locus and both puroindoline genes. Expression of the puroindoline genes in durum grain resulted in kernel texture and flour milling characteristics nearly identical to that of soft wheat, with high yields of break and straight-grade flours, which had small particle size and low starch damage. Dough water absorption was markedly reduced compared to durum flour and semolina. Dough was essentially unchanged and reflected the inherent gluten properties of the durum background. Pasta quality was essentially equal-to-or-better than pasta made from semolina. Agronomically, soft durum germplasm showed good potential with moderate grain yield and resistance to a number of fungal pathogens and insects. Future breeding efforts will no doubt further improve the quality and competitiveness of soft durum cultivars.

Keywords： soft durum wheat     grain hardness     puroindolines     milling     baking     pasta     noodles    

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Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 24-32 doi: 10.1007/s11684-014-0312-8

Abstract:

In this review, we summarize the novel findings from our series of studies on the leading metastasis-related gene, osteopontin (OPN). In our previous gene expression profiling study, OPN was identified as one of the leading genes associated with the metastasis of hepatocellular carcinoma (HCC). We focused on OPN to evaluate its prognostic values and important roles in HCC metastasis. A retrospective study of large cohorts of HCC patients demonstrated that plasma OPN level was one of the leading independent prognostic factors for HCC patients, even in the early stage of HCC, and could serve as a surrogate serologic biomarker for monitoring the treatment response and tumor recurrence after HCC resection. Using both in vitro and in vivoinvestigations, we found that OPN has an important role in metastasis and tumor growth of HCC and is an attractive potential therapeutic target for combating HCC metastasis. We also found that OPN+ HCC cells have much more amplifications at chromosomal regions, and promoter polymorphisms are important in the regulation of OPN expression and tumor growth and lung metastasis of HCC.

Keywords： osteopontin (OPN)     hepatocellular carcinoma     metastasis     prognosis     therapeutic target     biomarker     genetic polymorphism    

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NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 646-657 doi: 10.1007/s11684-018-0643-y

Abstract: Results of and tumor proliferation experiments and F-fluorothymidine ( F-FLT) micro-positron emission

Keywords： androgen-independent prostate cancer     normal epithelial cell-specific 1/kallikrein 10     sodium/iodide symporter    

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Title Author Date Type Operation

Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa

DING Xiaofang, LI Honggang, XIONG Chengliang

Journal Article

Effect of process parameters on the density and porosity of laser melted AlSi10Mg/SiC metal matrix composite

FAMODIMU, Mark STANFORD, Chike F. ODUOZA, Lijuan ZHANG

Journal Article

Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis

Journal Article

PM10 emissions from industrial coal-fired chain-grate boilers

Xinghua Li, Junzan Han, Lei Duan

Journal Article

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

The most influential “Top 10 Events” in carbon neutrality and climate change in 2022

Journal Article

Effect of IL-10 on formation of foam cell induced by ox-LDL

WANG Fei, DAI Yalei, XU Ting, XU Bo, WANG Kaifeng

Journal Article

Preface of special issue of the 10 th International Conference on CO 2 Utilization

Changjun LIU,

Journal Article

Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in

Journal Article

GENOME EDITING: A GROUND BREAKING RESEARCH HAS BEEN RANKED TOP 10 ENGINEERING FRONTS FROM 2017 TO 2021

Journal Article

Pressure drop analysis on the positive half-cell of a cerium redox flow battery using computational fluid dynamics: Mathematical and modelling aspects of porous media

Fernando F. Rivera, Berenice Miranda-Alcántara, Germán Orozco, Carlos Ponce de León, Luis F. Arenas

Journal Article

Development of soft kernel durum wheat

Craig F. MORRIS

Journal Article

Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Journal Article

NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation

Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li

Journal Article