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Clustered regularly interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9) 1

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Catalysis and deactivation of montmorillonite K10 in the aryl O -glycosylation of glycosyl trichloroacetoimidates

Xiaoliu LI, Xinhao YAN, Zhiwei LI, Hua CHEN, Pingzhu ZHANG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 3,   Pages 342-347 doi: 10.1007/s11705-009-0279-1

Abstract: The catalysis of montmorillonite K10 (MK10) for aryl -glycosylation of glycosyl trichloroacetimidatesIt was found that the catalyst MK10 is deactivated gradually in the recycle glycosylation.

Keywords: photoelectron spectroscopy     adsorption-desorption     glycosylation     deactivated     diffraction    

Emerging roles of podoplanin in vascular development and homeostasis

Yanfang Pan,Lijun Xia

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 421-430 doi: 10.1007/s11684-015-0424-9

Abstract:

Podoplanin (PDPN) is a mucin-type O-glycoprotein expressed in diverse cell types, such as lymphatic endothelial cells (LECs) in the vascular system and fibroblastic reticular cells (FRCs) in lymph nodes. PDPN on LECs or FRCs activates CLEC-2 in platelets, triggering platelet activation and/or aggregation through downstream signaling events, including activation of Syk kinase. This mechanism is required to initiate and maintain separation of blood and lymphatic vessels and to stabilize high endothelial venule integrity within lymph nodes. In the vascular system, normal expression of PDPN at the LEC surface requires transcriptional activation of Pdpn by Prox1 and modification of PDPN with core 1-derived O-glycans. This review provides a comprehensive overview of the roles of PDPN in vascular development and lymphoid organ maintenance and discusses the mechanisms that regulate PDPN expression related to its function.

Keywords: podoplanin     CLEC-2     Prox1     O-glycosylation     lymphatic vascular development and maintenance     lymphoid    

IgG N-Glycosylation Cardiovascular Age Tracks Cardiovascular Risk Beyond Calendar Age Article

Zhiyuan Wu, Zheng Guo, Yulu Zheng, Yutao Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Lois Balmer, Xia Li, Lixin Tao, Xiuhua Guo, Wei Wang

Engineering 2023, Volume 26, Issue 7,   Pages 99-107 doi: 10.1016/j.eng.2022.12.004

Abstract: However, the usable capacity of IgG N-glycosylation profiles for the risk stratification of cardiovascularlearning (recursive feature elimination and penalized regression algorithms) and developed an IgG N-glycosylationThe GlyCage index developed in this study can thus be used to track cardiovascular health using IgG N-glycosylationbetween GlyCage and calendar age independently indicates the cardiovascular risk, suggesting that IgG N-glycosylation

Keywords: IgG N-glycosylation cardiovascular age     Cardiovascular aging     Immunoglobulin G     Glycosylation     Inflammation    

Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation Review

Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko

Engineering 2023, Volume 26, Issue 7,   Pages 17-31 doi: 10.1016/j.eng.2023.03.013

Abstract: Glycosylation influences the physical and chemical properties of proteins, as well as their biologicalUnsurprisingly, alterations in protein glycosylation have been implicated in a growing number of humanAlthough glycosylation pathways are biochemically well-studied, little is known about the networks ofNext, in Section 3, we summarize, systemize, and generalize the results from current N-glycosylationsuch studies have been limited to an analysis of the human blood plasma N-glycome and the N-glycosylation

Keywords: Glycome     Glycans     N-glycosylation     Genomics     Genetics     GWAS    

Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients Article

Marina Kljaković-Gašpić Batinjan, Tea Petrović, Frano Vučković, Irzal Hadžibegović, Barbara Radovani, Ivana Jurin, Lovorka Đerek, Eva Huljev, Alemka Markotić, Ivica Lukšić, Irena Trbojević-Akmačić, Gordan Lauc, Ivan Gudelj, Rok Čivljak

Engineering 2023, Volume 26, Issue 7,   Pages 54-62 doi: 10.1016/j.eng.2022.08.007

Abstract: analyzed and compared the total IgG glycome—at the level of individual glycan structures and derived glycosylationIgG glycosylation in influenza patients was more time-dependent: In the first seven days of the diseaseThe similarity of IgG glycosylation changes in COVID-19 survivors and influenza patients may be the consequence

Keywords: Influenza     COVID-19     Viral infection     Glycosylation     Immunoglobulin G     Pneumonia    

Bidirectional Causality Between Immunoglobulin G N-Glycosylation and Metabolic Traits: A Mendelian Randomization Article

Xiaoni Meng, Weijie Cao, Di Liu, Isinta Maranga Elijah, Weijia Xing, Haifeng Hou, Xizhu Xu, Manshu Song, Youxin Wang

Engineering 2023, Volume 26, Issue 7,   Pages 74-88 doi: 10.1016/j.eng.2022.11.004

Abstract:

Bidirectional causalityAlthough the association between immunoglobulin G (IgG) N-glycosylation andin the reverse MR analysis of the integrated metabolic-QTL variants with the GWAS results for IgG N-glycosylationGP9 (HDL-C)) genetically determined metabolic traits were found to be related to the risk of IgG N-glycosylationcomprehensively bidirectional MR analyses provide suggestive evidence of bidirectional causality between IgG N-glycosylationand metabolic traits, possibly revealing a new richness in the biological mechanism between IgG N-glycosylation

Keywords: Mendelian randomization study     Immunoglobulin G     N-glycosylation     Metabolic traits     Quantitative trait    

Periodic Changes in the N-Glycosylation of Immunoglobulin G During the Menstrual Cycle Article

Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc

Engineering 2023, Volume 26, Issue 7,   Pages 108-118 doi: 10.1016/j.eng.2022.10.020

Abstract: The modification of IgG N-glycosylation is considered to be one of the various mechanisms by which sexcycle is the central sex hormone-related physiological process in most women of reproductive age, IgG N-glycosylationWe observed cyclic periodic changes in the N-glycosylation of IgG in association with the menstrual cycleOn the integrated cohort level, the modeled average menstrual cycle effect on the abundance of IgG N-glycosylationthe menstrual cycle phase could explain up to 0.72% of the variation in the abundance of a single IgG glycosylation

Keywords: N-glycosylation     Immunoglobulin G     Menstrual cycle     Female sex hormones     Estrogen     Progesterone     Testosterone    

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 322-338 doi: 10.1007/s11684-021-0901-2

Abstract: Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration (FDA) approvals for various indications. To date, six chimeric antigen receptor T cell (CAR-T) therapies have been permitted for the treatment of certain patients with relapsed/refractory hematologic malignancies. However, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or they reported life-threatening treatment-related damages to healthy tissues. The simultaneous expression of target antigens by healthy organs and tumor cells is partly responsible for such toxicities. Alongside targeting tumor-specific antigens, targeting the aberrantly glycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-T therapies. Tn, T, and sialyl-Tn antigens have been reported to be involved in tumor progression and metastasis, and their expression results from the dysregulation of a series of glycosyltransferases and the endoplasmic reticulum protein chaperone, Cosmc. Moreover, these glycoforms have been associated with various types of cancers, including prostate, breast, colon, gastric, and lung cancers. Here, we discuss how underglycosylated antigens emerge and then detail the latest advances in the development of CAR-T-based immunotherapies that target some of such antigens.

Keywords: cancer immunotherapy     chimeric antigen receptor     solid tumors     tumor-associated antigen     glycosylation    

Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis

Hui Xue, Dike Tao, Yuteng Weng, Qiqi Fan, Shuang Zhou, Ruilin Zhang, Han Zhang, Rui Yue, Xiaogang Wang, Zuolin Wang, Yao Sun

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 575-589 doi: 10.1007/s11684-019-0693-9

Abstract: the potential role of DMP1-PG in fracture repair, we established a mouse fracture model by using a glycosylation

Keywords: fracture     extracellular matrix     dentin matrix protein 1     proteoglycan     cartilage    

Novel Insight into the Etiology of Haff Disease by Mapping the N-Glycome with Orthogonal Mass Spectrometry Article

Si Liu, Yuanyuan Liu, Jiajing Lin, Bi-Feng Liu, Zhenyu He, Xiaomin Wu, Xin Liu

Engineering 2023, Volume 26, Issue 7,   Pages 63-73 doi: 10.1016/j.eng.2022.09.012

Abstract: would assist in deciphering the underlying molecular mechanism of the disease, whereas HD-associated glycosylationOur study reveals the association of differential IgG N-glycosylation with HD, providing new insight

Keywords: Haff disease     Serum     Immunoglobulin G     Glycosylation     Disease pathogenesis    

Human Prostate-Specific Antigen Carries N-Glycans with Ketodeoxynononic Acid Article

Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer

Engineering 2023, Volume 26, Issue 7,   Pages 119-131 doi: 10.1016/j.eng.2023.02.009

Abstract: This unusual glycosylation feature was also identified in a urinary PSA cohort in relation to prostate

Keywords: Ketodeoxynononic acid     Kdn     Glycosylation     Prostate cancer     Prostate-specific antigen    

Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications Article

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Engineering 2021, Volume 7, Issue 10,   Pages 1441-1451 doi: 10.1016/j.eng.2020.07.014

Abstract: All seven glycosylation sites in human angiotensin I converting enzyme 2 (hACE2) were found to be completelyHowever, glycosylation did not directly contribute to the binding affinity between HCoV-19 S protein

Keywords: N-glycosylation     COVID-19     Spike protein     hACE2     Structure    

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation Article

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Engineering 2024, Volume 32, Issue 1,   Pages 58-69 doi: 10.1016/j.eng.2023.09.019

Abstract: the mutual activation of HNF1A–FOXA2 and HNF4A–FOXA2 affecting glyco-genes and protein glycosylation

Keywords: factor 1 alpha (HNF1A)     Hepatocyte nuclear factor 4 alpha (HNF4A)     Forkhead box protein A2 (FOXA2)     N-glycosylation    

High-Throughput Profiling of Serological Immunoglobulin G N-Glycome as a Noninvasive Biomarker of Gastrointestinal Cancers Article

Pengcheng Liu, Xiaobing Wang, Aishe Dun, Yutong Li, Houqiang Li, Lu Wang, Yichun Zhang, Cancan Li, Jinxia Zhang, Xiaoyu Zhang, Lixing Ma, Haifeng Hou

Engineering 2023, Volume 26, Issue 7,   Pages 44-53 doi: 10.1016/j.eng.2023.02.008

Abstract:

Immunoglobulin G (IgG) N-glycosylation plays a crucial role in the developmentCanonical correlation analysis (CCA) was used to explore the correlation between IgG N-glycosylationOur findings demonstrate that IgG N-glycosylation plays an important role in modulating the pathogenesisSerological IgG N-glycosylation is thus a potential candidate for noninvasively assisting in the clinical

Keywords: Gastrointestinal cancer     Glycosylation     Immunoglobulin G     Diagnostic biomarker    

Title Author Date Type Operation

Catalysis and deactivation of montmorillonite K10 in the aryl O -glycosylation of glycosyl trichloroacetoimidates

Xiaoliu LI, Xinhao YAN, Zhiwei LI, Hua CHEN, Pingzhu ZHANG,

Journal Article

Emerging roles of podoplanin in vascular development and homeostasis

Yanfang Pan,Lijun Xia

Journal Article

IgG N-Glycosylation Cardiovascular Age Tracks Cardiovascular Risk Beyond Calendar Age

Zhiyuan Wu, Zheng Guo, Yulu Zheng, Yutao Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Lois Balmer, Xia Li, Lixin Tao, Xiuhua Guo, Wei Wang

Journal Article

Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation

Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko

Journal Article

Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients

Marina Kljaković-Gašpić Batinjan, Tea Petrović, Frano Vučković, Irzal Hadžibegović, Barbara Radovani, Ivana Jurin, Lovorka Đerek, Eva Huljev, Alemka Markotić, Ivica Lukšić, Irena Trbojević-Akmačić, Gordan Lauc, Ivan Gudelj, Rok Čivljak

Journal Article

Bidirectional Causality Between Immunoglobulin G N-Glycosylation and Metabolic Traits: A Mendelian Randomization

Xiaoni Meng, Weijie Cao, Di Liu, Isinta Maranga Elijah, Weijia Xing, Haifeng Hou, Xizhu Xu, Manshu Song, Youxin Wang

Journal Article

Periodic Changes in the N-Glycosylation of Immunoglobulin G During the Menstrual Cycle

Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc

Journal Article

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?

Journal Article

Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis

Hui Xue, Dike Tao, Yuteng Weng, Qiqi Fan, Shuang Zhou, Ruilin Zhang, Han Zhang, Rui Yue, Xiaogang Wang, Zuolin Wang, Yao Sun

Journal Article

Novel Insight into the Etiology of Haff Disease by Mapping the N-Glycome with Orthogonal Mass Spectrometry

Si Liu, Yuanyuan Liu, Jiajing Lin, Bi-Feng Liu, Zhenyu He, Xiaomin Wu, Xin Liu

Journal Article

Human Prostate-Specific Antigen Carries N-Glycans with Ketodeoxynononic Acid

Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer

Journal Article

Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications

Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li

Journal Article

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Journal Article

High-Throughput Profiling of Serological Immunoglobulin G N-Glycome as a Noninvasive Biomarker of Gastrointestinal Cancers

Pengcheng Liu, Xiaobing Wang, Aishe Dun, Yutong Li, Houqiang Li, Lu Wang, Yichun Zhang, Cancan Li, Jinxia Zhang, Xiaoyu Zhang, Lixing Ma, Haifeng Hou

Journal Article