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Molecular Characteristics, Functions, and Related Pathogenicity of MERS-CoV Proteins Review

Yan-Hua Li, Chen-Yu Hu, Nan-Ping Wu, Hang-Ping Yao, Lan-Juan Li

Engineering 2019, Volume 5, Issue 5,   Pages 940-947 doi: 10.1016/j.eng.2018.11.035

Abstract: > coronavirus—Middle East respiratory syndrome coronavirus (MERS-CoV)—that is associatedHowever, the mechanism by which MERS-CoV infects humans remains unclear.Although rapid diagnostic and public health measures are currently being implemented, new cases of MERS-CoVFor this purpose, detailed information on MERS-CoV proteins is needed.In this review, we describe the major structural and nonstructural proteins of MERS-CoV and summarize

Keywords： MERS-CoV     Spike protein     Structural protein     Accessory protein     Nonstructural protein    

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Human monoclonal antibodies as candidate therapeutics against emerging viruses

Yujia Jin, Cheng Lei, Dan Hu, Dimiter S. Dimitrov, Tianlei Ying

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 462-470 doi: 10.1007/s11684-017-0596-6

Abstract:

The emergence of new pathogens, such as severe acute respiratory syndrome coronavirus (SARS-CoV),Middle East respiratory syndrome coronavirus (MERS-CoV), and Ebola virus, poses serious challenges toWe also review the application of recently developed human mAbs against SARS-CoV, MERS-CoV, and Ebola

Keywords： human monoclonal antibodies     emerging infectious diseases     SARS-CoV     MERS-CoV     Ebola virus    

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Middle East respiratory syndrome coronavirus in pediatrics: a report of seven cases from Saudi Arabia

Sarah H. Alfaraj, Jaffar A. Al-Tawfiq, Talal A. Altuwaijri, Ziad A. Memish

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 126-130 doi: 10.1007/s11684-017-0603-y

Abstract: Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as an importantA review of studies conducted from June 2012 to April 19, 2016 reported 31 pediatric MERS-CoV cases.In this paper, we present the clinical and laboratory features of seven patients with pediatric MERS.other patients (43%) were asymptomatic and were in contact with patients with confirmed diagnosis of MERS-CoVThe documented MERS-CoV Ct values were 32–38 for four of the seven cases.

Keywords： Middle East respiratory syndrome coronavirus     MERS-CoV     pregnancy     pediatrics    

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Molecular aspects of MERS-CoV

Ali A. Rabaan, Ali M. Bazzi, Shamsah H. Al-Ahmed, Jaffar A. Al-Tawfiq

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 365-377 doi: 10.1007/s11684-017-0521-z

Abstract:

Middle East respiratory syndrome coronavirus (MERS-CoV) is a betacoronavirus which can cause acuteMERS-CoV ancestors may be found in Old World bats of the Vespertilionidae family.After a proposed bat to camel switching event, transmission of MERS-CoV to humans is likely to have beenbroad-spectrum antiviral nitazoxanide has been shown to have in vitro activity against MERS-CoVGLS-5300, a prophylactic DNA-plasmid vaccine encoding S protein, is the first MERS-CoV vaccine to be

Keywords： MERS-CoV     Saudi Arabia     spike protein     transmission     evolution     vaccine    

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From SARS to MERS: evidence and speculation

Hainv Gao,Hangping Yao,Shigui Yang,Lanjuan Li

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 377-382 doi: 10.1007/s11684-016-0466-7

Abstract:

The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic pathogen.In 2012, the infectious outbreak caused by MERS-CoV in Saudi Arabia has spread to more than 1600 patientsWithout a travel history, few clinical and radiological features can reliably differentiate MERS fromBut in real world, comparing with SARS, MERS presents more vaguely defined epidemiology, more severeIn this review, we summarize the recent findings in the field of MERS-CoV, especially its molecular virology

Keywords： middle east respiratory syndrome     animal origin     cross-species transmission     monoclonal antibody    

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SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 185-195 doi: 10.1007/s11684-021-0913-y

Abstract: speed at which Chinese scientists identified severe acute respiratory syndrome coronavirus 2 (SARS-CoVFurther research should be undertaken to develop more effective vaccines against SARS-CoV-2 variants

Keywords： COVID-19     pandemics     SARS-CoV-2     vaccination    

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SARS-CoV-2 variants, immune escape, and countermeasures

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 196-207 doi: 10.1007/s11684-021-0906-x

Abstract: SARS-CoV-2 variants have aroused great concern and are expected to continue spreading.

Keywords： SARS-CoV-2     COVID-19     vaccine     immune escape     breakthrough     prevention    

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ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4,   Pages 603-622 doi: 10.15302/J-FASE -2021397

Abstract:

The COVID-19 infections caused by SARS-CoV-2 have resulted in millions of people being infected andDespite possessing antiviral traits the potential of bacteriocins to combat SARS-CoV-2 infection hasreview also provides a new insight into the cellular and molecular alterations which have made SARS-CoV

Keywords： of bacteriocins / antiviral therapeutics / immunomodulation / nanosensor technology / mutated SARS-CoV    

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Understanding risk of thrombosis with thrombocytopenia syndrome after Ad26.COV2.S vaccination

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 938-941 doi: 10.1007/s11684-021-0895-9

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Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 747-757 doi: 10.1007/s11684-022-0954-x

Abstract: Emerging SARS-CoV-2 variants have made COVID-19 convalescents susceptible to re-infection and have raisedparticipants were followed up at 3.3 (Visit 1), 9.2 (Visit 2), and 18.5 (Visit 3) months after SARS-CoVSimilarly, the responses of SARS-CoV-2 RBD-specific B cells and memory B cells were boosted by the secondthe inactivated vaccine (one or two doses), which enhanced neutralization against highly mutated SARS-CoV

Keywords： COVID-19 convalescent     SARS-CoV-2     inactivated vaccination     neutralizing antibody     B cell response    

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Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 816-819 doi: 10.1007/s11684-020-0823-4

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Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections

Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin, Qing Xie

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 644-648 doi: 10.1007/s11684-021-0847-4

Abstract: development of a broadly neutralizing antibody against severe acute respiratory syndrome coronavirus 2 (SARS-CoVreceptor-binding domain (RBD) of the spike (S) protein is the main target of neutralizing antibodies when SARS-CoV

Keywords： neutralizing antibody     antibody cocktail     SARS-CoV-2     COVID-19     therapeutic strategy    

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Less attention paid to waterborne SARS-CoV-2 spreading in Beijing urban communities

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 5, doi: 10.1007/s11783-021-1398-2

Abstract:

• A survey on individual’s perception of SARS-CoV-2 transmission was

Keywords： Environmental dissemination     Risk communication     Individual perception    

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Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection

Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 746-751 doi: 10.1007/s11684-020-0822-5

Abstract: caused by a newly discovered β coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoVHow long the adaptive immunity triggered by SARS-CoV-2 can last is of critical clinical relevance inAll samples were positive for IgGs against the S- and N-proteins of SARS-CoV-2.pseudovirus assay, with no difference in blocking the cell-entry of the 614D and 614G variants of SARS-CoVdeveloped from 614D variant may offer protection from the currently predominant 614D variant of SARS-CoV

Keywords： SARS-CoV-2     neutralizing antibodies     T-cell response    

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Middle East respiratory syndrome coronavirus: a comprehensive review

Mahmoud M. Shehata,Mokhtar R. Gomaa,Mohamed A. Ali,Ghazi Kayali

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 120-136 doi: 10.1007/s11684-016-0430-6

Abstract:

The Middle East respiratory syndrome coronavirus was first identified in 2012 and has since then remained uncontrolled. Cases have been mostly reported in the Middle East, however travel-associated cases and outbreaks have also occurred. Nosocomial and zoonotic transmission of the virus appear to be the most important routes. The infection is severe and highly fatal thus necessitating rapid and efficacious interventions. Here, we performed a comprehensive review of published literature and summarized the epidemiology of the virus. In addition, we summarized the virological aspects of the infection and reviewed the animal models used as well as vaccination and antiviral tested against it.

Keywords： MERS     coronavirus     review    

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Title Author Date Type Operation

Molecular Characteristics, Functions, and Related Pathogenicity of MERS-CoV Proteins

Yan-Hua Li, Chen-Yu Hu, Nan-Ping Wu, Hang-Ping Yao, Lan-Juan Li

Journal Article

Human monoclonal antibodies as candidate therapeutics against emerging viruses

Yujia Jin, Cheng Lei, Dan Hu, Dimiter S. Dimitrov, Tianlei Ying

Journal Article

Middle East respiratory syndrome coronavirus in pediatrics: a report of seven cases from Saudi Arabia

Sarah H. Alfaraj, Jaffar A. Al-Tawfiq, Talal A. Altuwaijri, Ziad A. Memish

Journal Article

Molecular aspects of MERS-CoV

Ali A. Rabaan, Ali M. Bazzi, Shamsah H. Al-Ahmed, Jaffar A. Al-Tawfiq

Journal Article

From SARS to MERS: evidence and speculation

Hainv Gao,Hangping Yao,Shigui Yang,Lanjuan Li

Journal Article

SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

Journal Article

SARS-CoV-2 variants, immune escape, and countermeasures

Journal Article

ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC

Journal Article

Understanding risk of thrombosis with thrombocytopenia syndrome after Ad26.COV2.S vaccination

Journal Article

Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination

Journal Article

Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Journal Article

Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections

Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin, Qing Xie

Journal Article

Less attention paid to waterborne SARS-CoV-2 spreading in Beijing urban communities

Journal Article

Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection

Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen

Journal Article

Middle East respiratory syndrome coronavirus: a comprehensive review

Mahmoud M. Shehata,Mokhtar R. Gomaa,Mohamed A. Ali,Ghazi Kayali

Journal Article