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Potential unreliability of variant allele frequency in the efficacy prediction of targeted therapy in NSCLC

Frontiers of Medicine 2024, Volume 18, Issue 3, Pages 570-570 doi: 10.1007/s11684-024-1076-4

Abstract: Potential unreliability of variant allele frequency in the efficacy prediction of targeted therapy in NSCLC

Keywords： therapy NSCLC unreliability variant allele

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Improved local control without elective nodal radiotherapy in patients with unresectable NSCLC treated

YANG Kunyu, LIU Li, ZHANG Tao, WU Gang, CAO Fengjun, WANG Jianhua

Frontiers of Medicine 2007, Volume 1, Issue 4, Pages 381-385 doi: 10.1007/s11684-007-0074-7

Abstract: To investigate the influence of prophylactic elective nodal irradiation on the therapeutic results of definitive radiotherapy for patients with stage IIIA or stage IIIB unresectable non-small-cell lung cancer, 55 patients with clinically inoperable advanced non-small-cell lung cancer were studied. After four cycles of induction chemotherapy, the patients were divided into two groups at random. In one group, the elective nodal irradiation was included in clinical tumor volume (CTV) of definitive radiotherapy (ENI group); and in the other group, elective nodal irradiation was not included in CTV (non-ENI group). For the patients in the ENI group, the mean prescription dose for gross tumor volumes was 58.4 Gy, while for the patients in the non-ENI group, it was 65.8 Gy (<0.05). The responsive rates were 45.8% and 74.0% (<0.05), and the rate of the elective nodal failure (ENF) was 4.2% and 11.1%, respectively. Kaplan-Meier analysis showed that the mean local-progression-free survival time was 11.0 and 15.0 months, and one-year local-failure rates were 51.9% and 24.5% (<0.05). The median overall survival time was 13.0 and 15.0 months, respectively ( = 0.084). The one-year survival rates were 55.7% and 72.5%, and two-year survival rates were 0% and 19.9%. There was no significant difference in the occurrences of radiation-associated complications between the two groups. Our results showed that omitting elective nodal irradiation did not result in a high incidence of elective nodal failure. On the contrary, it decreased local failure by increasing prescription doses to the primary diseases and lymphadenopaphy, and thereby it may further prolong the patients survival.

Keywords： significant difference irradiation unresectable non-small-cell induction chemotherapy influence

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Identification of an E3 ligase-encoding gene

Yanfei Zhang, Xinchun Zhao, Yongchun Zhou, Min Wang, Guangbiao Zhou

Frontiers of Medicine 2020, Volume 14, Issue 3, Pages 318-326 doi: 10.1007/s11684-019-0708-6

Abstract: In order to unveil ubiquitin pathway genes (UPGs) that are essential for non-small cell lung cancer (NSCLCscreening experiment to knockdown the expression of 696 UPGs found in the human genome in A549 and H1975 NSCLCthe repair of DNA interstrand cross-links in response to DNA damage, led to dramatic inhibition of NSCLCKnockdown of suppressed colony forming activity of NSCLC cells.These results show for the first time that is required for NSCLC cell proliferation and may have an

Keywords： RFWD3 NSCLC prognosis tobacco smoke

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Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy in NSCLC

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 493-502 doi: 10.1007/s11684-022-0946-x

Abstract: lymphoma kinase (ALK) is the most common fusion gene involved in non-small cell lung cancer (NSCLCcapture-based NGS is probably unreliable for ITH assessment and targeted therapy efficacy prediction in NSCLC

Keywords： ALK fusion next-generation sequencing fluorescence in situ hybridization immunohistochemistry variant allele frequency intratumoral heterogeneity targeted therapy

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Evaluation of molecular residual disease in operable non-small cell lung cancer with gene fusions, exon skipping or amplification

Frontiers of Medicine 2024, Volume 18, Issue 4, Pages 735-743 doi: 10.1007/s11684-024-1060-z

Abstract: residual disease (MRD) based on circulating tumor DNA (ctDNA) in patients with non-small cell lung cancer (NSCLCThis prospective, non-intervention study recruited 49 patients with operable NSCLC with actionable geneknowledge, this is the first comprehensive study on ctDNA-MRD clinical detection efficacy in operable NSCLC

Keywords： ctDNA molecular residual disease operable NSCLC gene fusion MET exon skipping MET