Search scope:
排序: Display mode:
Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases
Chong Liu, Dingfeng Su
Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 35-40 doi: 10.1007/s11684-012-0171-0
Keywords: α7 nicotinic acetylcholine receptor cardiovascular diseases baroreflex sensitivity
Peter B. Alexander,Xiao-Fan Wang
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 134-138 doi: 10.1007/s11684-015-0396-9
Keywords: targeted therapy drug resistance receptor tyrosine kinases cancer
Wenjie Zhu, Binghe Xu
Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 208-220 doi: 10.1007/s11684-020-0795-4
Keywords: endocrine-resistant HR+/HER2- advanced breast cancer randomized clinical trials meta-analysis targeted therapy
Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 699-713 doi: 10.1007/s11684-022-0972-8
Keywords: anti-CD19 chimeric antigen receptor T immunotherapy diffuse large B cell lymphoma tumor microenvironment
Chimeric antigen receptor T cell therapies for acute myeloid leukemia
Bin Gu, Jianhong Chu, Depei Wu
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 701-710 doi: 10.1007/s11684-020-0763-z
Keywords: acute myeloid leukemia CAR T immunotherapy
Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy
Zhao Zhang, Jun Jiang, Xiaodong Wu, Mengyao Zhang, Dan Luo, Renyu Zhang, Shiyou Li, Youwen He, Huijie Bian, Zhinan Chen
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 57-68 doi: 10.1007/s11684-019-0683-y
Keywords: chimeric antigen receptor T cells epidermal growth factor receptor lung cancer immunotherapy tumor immunolog
Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages
LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao
Frontiers of Medicine 2008, Volume 2, Issue 2, Pages 166-170 doi: 10.1007/s11684-008-0030-1
Changlin Cao, Jingxian Gu, Jingyao Zhang
Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 169-177 doi: 10.1007/s11684-017-0505-z
Keywords: soluble triggering receptor expressed on myeloid cells-1 infectious diseases diagnosis and prognosis
Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,
Frontiers of Medicine 2009, Volume 3, Issue 3, Pages 309-315 doi: 10.1007/s11684-009-0043-4
Keywords: graft vs host disease proteinase-activated receptor murine model hematopoietic stem cell transplantation
A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma
Houli Zhao, Yiyun Wang, Elaine Tan Su Yin, Kui Zhao, Yongxian Hu, He Huang
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 711-725 doi: 10.1007/s11684-020-0808-3
Keywords: chimeric antigen receptor T (CAR-T) cell lymphoma cytokine release syndrome (CRS) immune effector cell-associated
XU Aijun, TIAN Yuke, DUAN Shiming
Frontiers of Medicine 2007, Volume 1, Issue 2, Pages 207-210 doi: 10.1007/s11684-007-0039-x
Lili Zhou, Ping Li, Shiguang Ye, Xiaochen Tang, Junbang Wang, Jie Liu, Aibin Liang
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 786-791 doi: 10.1007/s11684-020-0751-3
Keywords: anti-CD19 chimeric antigen receptor T cell soft tissue bone marrow relapsed or refractory non-Hodgkin
Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang
Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 288-303 doi: 10.1007/s11684-015-0412-0
Toll-like receptors (TLRs), which are found in innate immune cells, are essential mediators of rapid inflammatory responses and appropriate T-cell activation in response to infection and tissue damage. Accumulating evidence suggests that TLR signaling is involved in normal hematopoiesis and specific hematologic pathologies. Particular TLRs and their downstream signaling mediators are expressed not only in terminally differentiated innate immune cells but also in early hematopoietic progenitors. Sterile activation of TLR signaling is required to generate early embryonic hematopoietic progenitor cells. In adult animals, TLR signaling directly or indirectly promotes differentiation of myeloid cells at the expense of that of lymphoid cells and the self-renewal of hematopoietic stem cells during infection and tissue damage. Activating mutations of the MyD88 gene, which codes for a key adaptor involved in TLR signaling, are commonly detected in B-cell lymphomas and other B-cell hematopathologies. Dysregulated TLR signaling contributes to the pathogenesis of many hematopoietic disorders, including bone marrow failure, myelodysplastic syndrome, and acute myeloid leukemia. Complete elucidation of the molecular mechanisms by which TLR signaling mediates the regulation of both normal and pathogenic hematopoiesis will prove valuable to the development of targeted therapies and strategies for improved treatment of hematopoietic disorders.
Keywords: TLR MyD88 hematopoiesis bone marrow failure leukemia myelodysplastic syndrome
ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen
Frontiers of Medicine 2008, Volume 2, Issue 1, Pages 19-24 doi: 10.1007/s11684-008-0005-2
Keywords: therapy Sprague administration cardiac hypertrophy valsartan
Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease
Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu
Frontiers of Medicine 2020, Volume 14, Issue 1, Pages 81-90 doi: 10.1007/s11684-019-0692-x
Keywords: soluble C-type lectin-like receptor-2 coronary artery disease risk factor
Title Author Date Type Operation
Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases
Chong Liu, Dingfeng Su
Journal Article
Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies
Peter B. Alexander,Xiao-Fan Wang
Journal Article
Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factorreceptor 2-negative (HR
Wenjie Zhu, Binghe Xu
Journal Article
microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor
Journal Article
Chimeric antigen receptor T cell therapies for acute myeloid leukemia
Bin Gu, Jianhong Chu, Depei Wu
Journal Article
Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy
Zhao Zhang, Jun Jiang, Xiaodong Wu, Mengyao Zhang, Dan Luo, Renyu Zhang, Shiyou Li, Youwen He, Huijie Bian, Zhinan Chen
Journal Article
Blockage of receptor-interacting protein 2 expression by small interfering RNA in murine macrophages
LIU Hongchun, CAO Zhongwei, JIN Jianjun, WANG Jiyao
Journal Article
Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis
Changlin Cao, Jingxian Gu, Jingyao Zhang
Journal Article
Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host
Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,
Journal Article
A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma
Houli Zhao, Yiyun Wang, Elaine Tan Su Yin, Kui Zhao, Yongxian Hu, He Huang
Journal Article
Effects of intracerebroventricular NMDA and non-NMDA receptor agonists or antagonists on general anesthesia
XU Aijun, TIAN Yuke, DUAN Shiming
Journal Article
affect the survival of patients with relapsed or refractory non-Hodgkin lymphoma after chimeric antigen receptor
Lili Zhou, Ping Li, Shiguang Ye, Xiaochen Tang, Junbang Wang, Jie Liu, Aibin Liang
Journal Article
Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases
Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang
Journal Article
Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy
ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen
Journal Article