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Intracellular and extracellular TGF-β signaling in cancer: some recent topics

Kohei Miyazono, Yoko Katsuno, Daizo Koinuma, Shogo Ehata, Masato Morikawa

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 387-411 doi: 10.1007/s11684-018-0646-8

Abstract:

Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, includingAlthough tumor-suppressive roles of TGF-β have been extensively studied and well-characterized inmany cancers, especially at early stages, accumulating evidence has revealed the critical roles of TGFTGF-β is produced as latent high molecular weight complexes, and the latent TGF-β complex expressedInhibition of the TGF-β activities through regulation of the latent TGF-β complex activation

Keywords： TGF-β EMT lung cancer pancreatic cancer latent form immune function GARP

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Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice

CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang

Frontiers of Medicine 2008, Volume 2, Issue 2, Pages 154-165 doi: 10.1007/s11684-008-0029-7

Abstract: 1 (TGF-?1) and collagen I (Col I) protein was detected by immunohistochemistry.The effect of soluble egg antigen (SEA) and PAE on the production of TGF-?The effect of TGF-?-SMA, TGF-?1 and Col I protein in the pre-treatment group.TGF-?1 could be secreted from PM?s stimulated by SEA. Meanwhile, the production of TGF-?1 from PM?

Keywords： cercariae collagen hyaluronic OPMCM soluble

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initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β

Frontiers of Medicine doi: 10.1007/s11684-023-1010-1

Abstract: initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β

Keywords： exosomes induce activation impair function CD19 exosomal CD19 antigen

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Genome-wide search for candidate genes determining vertebrae number in pigs

Longchao ZHANG, Jingwei YUE, Xin LIU, Jing LIANG, Kebin ZHAO, Hua YAN, Na LI, Lei PU, Yuebo ZHANG, Huibi SHI, Ligang WANG, Lixian WANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3, Pages 327-334 doi: 10.15302/J-FASE-2017163

Abstract: Haplotype sharing and block analysis refined the QTL to an interval of about 3 Mb containing 29 candidate

Keywords： genome-wide association study number of vertebrae pig SSC7 TGFβ3

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Zfyve16 regulates the proliferation of B-lymphoid cells

Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren

Frontiers of Medicine 2018, Volume 12, Issue 5, Pages 559-565 doi: 10.1007/s11684-017-0562-3

Abstract: The FYVE protein SARA regulates the TGF-β signaling pathway by recruiting Smad2/3 and accelerating theirphosphorylation, thereby altering their susceptibility to TGF-β-mediated T cell suppression.Zfyve16 binds to Smad4 and their binding affects the formation of Smad2/3-Smad4 complex in TGF-β signalingThis finding is consistent with the role of Zfyve16 in facilitating TGF-β signaling.These results suggest that Zfyve16 inhibits the proliferation of T cells, possibly through the TGF-β

Keywords： Zfyve16 endofin hematopoiesis TGF-β lymphocytes

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Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibition of transforming growth factor β-induced Smad signaling

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4, Pages 445-455 doi: 10.1007/s11684-014-0378-3

Abstract: and cardiac fibroblast activation but did not block TAC-induced transforming growth factor-β1 (TGF-β1) production and phosphorylation of Smad2/3.In isolated cardiac fibroblasts, sildenafil blocked TGF-β1-induced cardiac fibroblast transformation

Keywords： PDE5 cardiac fibrosis TGF-β CREB

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Xiaohan: Traditional Chinese Medicine Talks About Health, Dietary Supplement and Improving Immunity (2020-3-

18 Apr 2022

Keywords：营养健康

Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 4, Pages 343-348 doi: 10.1007/s11705-007-0062-0

Abstract: An oxetane-derived monomer, 3-acryloyloxymethyl-3′-methyloxetane (AMO) was prepared from the reactionof 3-hydromethyl-3-methyloxetane with acryloyl chloride.The cationic ring-opening copolymerization of AMO with another oxetane-derived monomer, 3-(2-(2-(2-methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane (MEMO) was conducted in CHCl solution using BF3 ·OEt/1, 4-butanediol

Keywords： 4-butanediol 2-methoxyethylenoxy consistent oxetane-derived copolymer

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Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Frontiers of Medicine 2008, Volume 2, Issue 1, Pages 95-99 doi: 10.1007/s11684-008-0017-y

Abstract: The Sj14-3-3 gene was amplified and subcloned into the expression vector pPICZ?The protein of rSj14-3-3 was prepared and purified and BALB/c mice were immunized which was followedThe Sj14-3-3 gene was expressed and secreted into the medium and its molecular weight was about 35000antibody and rSj14-3-3 had a promising immune reactivity.The recombinant Sj14-3-3 of eukaryotic expression in was successfully harvested.

Keywords： development challenging rSj14-3-3 resistance cultural supernatant

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第四届高性能编译、计算和通信国际会议(HP3C 2020)

Conference Date: 12 Mar 2020

Conference Place: 广东广州

Administered by: HP3C 2020

FOXP3 and Its Cofactors as Targets of Immunotherapies Review

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Engineering 2019, Volume 5, Issue 1, Pages 115-121 doi: 10.1016/j.eng.2019.01.001

Abstract:

Forkhead box P3 (FOXP3) is a "master regulator" of regulatory T cells (Tregs), which areAs a consequence, the PTMs change the stability of FOXP3 and its capability to regulate gene expressionAlthough FOXP3 per se is not an ideal drug target, deacetylases, acetyltransferases, kinases, and other enzymes that regulate the PTMs of FOXP3 are potential targets to modulate FOXP3 and TregFOXP3" side effects must be considered when inhibitors to these enzymes are used.

Keywords： Treg Forkhead box P3 (FOXP3) Post-translational modification Autoimmune Cancer

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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Frontiers of Medicine doi: 10.1007/s11684-023-1003-0

Abstract: However, little is known about the function of Lipin3 in triglyceride (TG) metabolism.Hence, we generated Lipin3 heterozygous knockout (Lipin3-heKO) mice and cultured primary hepatocytesto explore the pathophysiological roles of Lipin3 in TG metabolism.Our study suggested that Lipin3 was a novel disease-causing gene inducing obesity and HTG.We also established a relationship between Lipin3 and mitochondrial dysfunction.

Keywords： Lipin3 Lipin1 hypertriglyceridemia obesity mitochondrial dysfunction

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A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

Engineering 2017, Volume 3, Issue 5, Pages 653-662 doi: 10.1016/J.ENG.2017.05.013

Abstract: With the rapid advancement of three-dimensional (3D) printing and 3D bioprinting technologies, many researchersThis paper reviews the applications of these 3D printing and 3D bioprinting technologies for the fabricationThis review specifically discusses the state of the art along with new developments and trends in 3Dmedical phantoms, radiologically relevant medical phantoms, and physiological medical phantoms) and 3D

Keywords： 3D printing 3D bioprinting Medical phantom Regenerated tissue/organ Scaffold

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2020第四届环境与能源工程国际会议(IC3E 2020)

Conference Date: 12 Mar 2020

Conference Place: 海南海口三亚

Administered by: APISE

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 269-273 doi: 10.1007/s11684-007-0051-1

Abstract: investigate the influence and the related mechanism of the gene on glucose uptake and insulin resistance in 3T3Radioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different gene expressionreal-time RT-PCR analysis were used to determine the mRNA levels of several glucose transport proteins in 3T3and glycogen synthase kinase-3b (GSK-3)., GSK-3 and p38MAPK, increased with overexpression in 3T3-L1 cells.

Keywords： 3T3-L1 influence resistance receptor substrate-1 transport

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Title Author Date Type Operation

Intracellular and extracellular TGF-β signaling in cancer: some recent topics

Kohei Miyazono, Yoko Katsuno, Daizo Koinuma, Shogo Ehata, Masato Morikawa

Journal Article

Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice

CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang

Journal Article

initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β

Journal Article

Genome-wide search for candidate genes determining vertebrae number in pigs

Longchao ZHANG, Jingwei YUE, Xin LIU, Jing LIANG, Kebin ZHAO, Hua YAN, Na LI, Lei PU, Yuebo ZHANG, Huibi SHI, Ligang WANG, Lixian WANG

Journal Article

Zfyve16 regulates the proliferation of B-lymphoid cells

Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren

Journal Article

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibition of transforming growth factor β-induced Smad signaling

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Journal Article

Xiaohan: Traditional Chinese Medicine Talks About Health, Dietary Supplement and Improving Immunity (2020-3-

18 Apr 2022

Conference Videos

Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Journal Article

Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Journal Article

第四届高性能编译、计算和通信国际会议(HP3C 2020)

12 Mar 2020

Conference Information

FOXP3 and Its Cofactors as Targets of Immunotherapies

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Journal Article

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and