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Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia

Geqing XIA MD, Zehua WANG MD, Li ZOU MD, Chaoying WU MS, Yu HU MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 235-240 doi: 10.1007/s11684-010-0002-0

Abstract: This study was aimed to detect maternal serum levels of thromboxane B2 (TXB2) in different durationsof pregnancy and explore the predictive value of TXB2 for preeclampsia.Maternal serum levels of TXB2 were measured by enzyme-linked immunoassay.of pregnancy, the levels of maternal serum TXB2 in the 180 cases gradually ascended as seen throughHigher levels of maternal serum TXB2 were detected a long time before clinical symptoms appeared.

Keywords： thromboxane B2     preeclampsia    

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An Eight-Step Continuous-Flow Total Synthesis of Vitamin B1

Meifen Jiang,Minjie Liu,Weijian Li,Yingqi Xia,Fener Chen,

Engineering doi: 10.1016/j.eng.2023.01.016

Abstract: Vitamin B1 is widely applied in the healthcare and food industry as an antineuritic and antioxidantThis study reports on an integrated eight-step continuous-flow synthesis of vitamin B1 fromcommercially available 2-cyanoacetamide.Vitamin B1 was produced with a separated yield of 47.7% and high purity, with a total residence

Keywords： Vitamin B1     Continuous-flow synthesis     Micro-reactor     Continuous manufacturing    

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Biotechnological Strategies of Riboflavin Biosynthesis in Microbes Review

Jia-Rong Zhang, Ying-Ying Ge, Pin-He Liu, Ding-Tao Wu, Hong-Yan Liu, Hua-Bin Li, Harold Corke, Ren-You Gan

Engineering 2022, Volume 12, Issue 5,   Pages 115-127 doi: 10.1016/j.eng.2021.03.018

Abstract:

Riboflavin is an essential micronutrient for humans and must be obtained exogenously from foods or supplements. Numerous studies have suggested a major role of riboflavin in the prevention and treatment of various diseases. There are mainly three strategies for riboflavin synthesis, including total chemical synthesis, chemical semi-synthesis, and microbial fermentation, the latter being currently the most promising strategy. In recent years, flavinogenic microbes have attracted increasing attention. Fungi, including Eremothecium ashbyii and Ashbya gossypii, and bacteria, including Bacillus subtilis, Escherichia coli, and lactic acid bacteria, are ideal cell factories for riboflavin overproduction. Thus they are good candidates for enhancing the level of riboflavin in fermented foods or designing novel riboflavin bio-enriched foods with improved nutritional value and/or beneficial properties for human health. This review briefly describes the role of riboflavin in human health and the historical process of its industrial production, and then highlights riboflavin biosynthesis in bacteria and fungi, and finally summarizes the strategies for riboflavin overproduction based on both the optimization of fermentation conditions and the development of riboflavin-overproducing strains via chemical mutagenesis and metabolic engineering. Overall, this review provides an updated understanding of riboflavin biosynthesis and can promote the research and development of fermented food products rich in riboflavin.

Keywords： Vitamin B2     Bacillus subtilis     Lactic acid bacteria     Fungi     Microbial fermentation    

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Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty

Yue Zhao, Wenjun Long, Caiqi Du, Huanhuan Yang, Shimin Wu, Qin Ning, Xiaoping Luo

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 174-181 doi: 10.1007/s11684-017-0544-5

Abstract:

The relationship between vitamin D deficiency and idiopathic central precocious puberty (ICPP) hasCorrelation analysis showed that vitamin D level is correlated with BMI and some metabolic parametersOur study suggested that vitamin D status may be associated with ICPP risk and may have a threshold effect

Keywords： idiopathic central precocious puberty     threshold effects     vitamin D status    

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Fenton oxidation of 2,4- and 2,6-dinitrotoluene and acetone inhibition

HE Yiliang, ZHAO Bin, HUGHES Joseph B., HAN Sung Soo

Frontiers of Environmental Science & Engineering 2008, Volume 2, Issue 3,   Pages 326-332 doi: 10.1007/s11783-008-0038-4

Abstract: The performances and kinetic parameters of Fenton oxidation of 2,4- and 2,6-dinitrotoluene (DNT) in water-acetone- and 2,6-DNT.- and 2,6-DNT completely, mainly due to the competition of hydroxyl radicals.Fenton oxidation of 2,4- and 2,6-DNT fit well with the first-order kinetics and the presence of acetone-DNT primary degradation was proposed: 2,4-DNT → 2,4-dinitro-benzaldehyde → 2,4-dinitrobenzoic acid →

Keywords： presence     2     4-DNT     competition     laboratory     scavenger    

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Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladder

FAN Xiaodong, HAN Ruifa

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 377-380 doi: 10.1007/s11684-007-0073-8

Abstract: Recombinant IFN--2b-BCG, wild-type BCG (wBCG), wild-type BCG and IFN--2b were coincubated with PBMCs

Keywords： Urology     powerful     2b-BCG     Tianjin institute     wild-type    

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Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination

Frontiers of Medicine   Pages 747-757 doi: 10.1007/s11684-022-0954-x

Abstract: Emerging SARS-CoV-2 variants have made COVID-19 convalescents susceptible to re-infection and have raisedefficacy of inactivated vaccination in neutralization against emerging variants and antigen-specific B, and 18.5 (Visit 3) months after SARS-CoV-2 infection.Similarly, the responses of SARS-CoV-2 RBD-specific B cells and memory B cells were boosted by the secondvariants and memory B cell responses.

Keywords： COVID-19 convalescent     SARS-CoV-2     inactivated vaccination     neutralizing antibody     B cell response    

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Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via tworeceptors: apolipoprotein E receptor 2' and glycoprotein I bα

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 76-84 doi: 10.1007/s11684-015-0426-7

Abstract: ba (GP I bα) in platelet activation induced by the anti-β2GP I /β2b/ III a activation and P-selectin expression andthromboxane B2 production as well as p38 mitogen-activated protein kinase phosphorylationactivate platelets, and this activation was inhibited by either the anti-GP I bα antibody or theactivation via GP I bα and apoER2', which may then contribute to the prothrombotic tendency

Keywords： anti-β2GP I /β2GP I complex     platelet     GP I bα     apoER2'     thrombosis    

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Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 200-206 doi: 10.1007/s11684-007-0038-y

Abstract: of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic of type 2

Keywords： palmitate     characteristic     study     plasma     resistance    

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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCCWe showed that the corepressor C-terminal-binding protein 2 (CtBP2) is a novel ALDOB-interacting proteinThe CtBP2-to-ALDOB expression ratio in clinical samples was correlated with the expression of CtBP2 targetALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelial4-methylthio 2-oxobutyric acid.

Keywords： ALDOB     kidney cancer     cell proliferation    

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A Novel Human Antibody, HF, against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method Article

Chunxia Qiao, Ming Lv, Xinying Li, Xiaoling Lang, Shouqin Lv, Mian Long, Yan Li, Shusheng Geng, Zhou Lin, Beifen Shen , Jiannan Feng

Engineering 2021, Volume 7, Issue 11,   Pages 1566-1576 doi: 10.1016/j.eng.2020.10.024

Abstract: display method (in vitro) or by transgenic mice (in vivo); other methods include BBased on the complex structure of human epidermal growth factor receptor 2 (HER2)/Herceptin, we firstdesigned six short peptides targeting the potential epitope of HER2 recognized by Herceptin.complementarity determining regions in a suitable immunoglobulin frame, giving birth to a novel anti-HER2

Keywords： HER2/erb-B2     Human antibody     Computer-aided design    

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Challenge of global climate change: Prospects for a new energy paradigm

Michael B. MCELROY

Frontiers of Environmental Science & Engineering 2010, Volume 4, Issue 1,   Pages 2-11 doi: 10.1007/s11783-010-0005-8

Abstract: Perspectives on the challenge posed by potential future climate change are presented including a discussion of prospects for carbon capture followed either by sequestration or reuse including opportunities for alternatives to the use of oil in the transportation sector. The potential for wind energy as an alternative to fossil fuel energy as a source of electricity is outlined including the related opportunities for cost effective curtailment of future growth in emissions of CO.

Keywords： climate change     carbon capture     wind     ethanol     CO2     radiative forcing    

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Hyperbranched azo polyurethane synthesized through A + B scheme

CHE Pengchao, HE Yaning, WANG Xiaogong

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 1,   Pages 123-126 doi: 10.1007/s11705-007-0078-5

Abstract: synthesized by one-step polymerization of an A type monomer diphenylmethane-4,4′-diisocyanate and a Btype monomer 4-(N,N′-bis(2-hydroxyethyl))amino-2′-hydroxyethoxyl-4′-nitro-azobenzene.

Keywords： dimethylformamide     one-step polymerization     polyurethane     2-hydroxyethyl     diphenylmethane-4     4′-diisocyanate    

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Three-dimensional face point cloud hole-filling algorithm based on binocular stereo matching and a B-spline Research Articles

Yuan HUANG, Feipeng DA,whhbb@163.com

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 3,   Pages 398-408 doi: 10.1631/FITEE.2000508

Abstract: When obtaining three-dimensional (3D) face point cloud data based on structured light, factors related to the environment, occlusion, and illumination intensity lead to holes in the collected data, which affect subsequent recognition. In this study, we propose a hole-filling method based on stereo-matching technology combined with a . The algorithm uses phase information acquired during raster projection to locate holes in the point cloud, simultaneously extracting boundary point cloud sets. By registering the face point cloud data using the stereo-matching algorithm and the data collected using the raster projection method, some supplementary information points can be obtained at the holes. The shape of the curve can then be roughly described by a few key points, and the control points are put into the hole area as key points for iterative calculation of surface reconstruction. Simulations using smooth ceramic cups and human face models showed that our model can accurately reproduce details and accurately restore complex shapes on the test surfaces. Simulation results indicated the robustness of the method, which is able to fill holes on complex areas such as the inner side of the nose without a prior model. This approach also effectively supplements the hole information, and the patched point cloud is closer to the original data. This method could be used across a wide range of applications requiring accurate facial recognition.

Keywords： Three-dimensional (3D) point cloud     Hole filling     Stereo matching     B-spline    

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Effect of bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involved

Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 225-228 doi: 10.1007/s11684-010-0003-z

Abstract: phosphoinositide 3-kinase (PI3K) inhibitor (LY294002), and BK+ Akt inhibitor to evaluate the expression of B2signaling molecules MAPK, Akt, and PI3K by Western blot. (1) BK markedly up-regulated the expression of B2receptor in VSMC. (2) Apigenin, PD98059, Akt inhibitor, and LY294002 inhibited up-regulation of B2 receptorinduced by BK. (3) Signal transduction pathways of MAPK and PI3K were involved in the up-regulation of B2Results suggest that bradykinin can up-regulate the expression of B2 receptor in VSMCs.

Keywords： bradykinin     vascular smooth muscle cells     signal transduction pathways    

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Title Author Date Type Operation

Detection of maternal serum thromboxane B2 in different durations of pregnancy and prediction of preeclampsia

Geqing XIA MD, Zehua WANG MD, Li ZOU MD, Chaoying WU MS, Yu HU MD,

Journal Article

An Eight-Step Continuous-Flow Total Synthesis of Vitamin B1

Meifen Jiang,Minjie Liu,Weijian Li,Yingqi Xia,Fener Chen,

Journal Article

Biotechnological Strategies of Riboflavin Biosynthesis in Microbes

Jia-Rong Zhang, Ying-Ying Ge, Pin-He Liu, Ding-Tao Wu, Hong-Yan Liu, Hua-Bin Li, Harold Corke, Ren-You Gan

Journal Article

Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty

Yue Zhao, Wenjun Long, Caiqi Du, Huanhuan Yang, Shimin Wu, Qin Ning, Xiaoping Luo

Journal Article

Fenton oxidation of 2,4- and 2,6-dinitrotoluene and acetone inhibition

HE Yiliang, ZHAO Bin, HUGHES Joseph B., HAN Sung Soo

Journal Article

Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladder

FAN Xiaodong, HAN Ruifa

Journal Article

Neutralization against SARS-CoV-2 Delta/Omicron variants and B cell response after inactivated vaccination

Journal Article

Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via tworeceptors: apolipoprotein E receptor 2' and glycoprotein I bα

Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu

Journal Article

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Journal Article

Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Journal Article

A Novel Human Antibody, HF, against HER2/erb-B2 Obtained by a Computer-Aided Antibody Design Method

Chunxia Qiao, Ming Lv, Xinying Li, Xiaoling Lang, Shouqin Lv, Mian Long, Yan Li, Shusheng Geng, Zhou Lin, Beifen Shen , Jiannan Feng

Journal Article

Challenge of global climate change: Prospects for a new energy paradigm

Michael B. MCELROY

Journal Article

Hyperbranched azo polyurethane synthesized through A + B scheme

CHE Pengchao, HE Yaning, WANG Xiaogong

Journal Article

Three-dimensional face point cloud hole-filling algorithm based on binocular stereo matching and a B-spline

Yuan HUANG, Feipeng DA,whhbb@163.com

Journal Article

Effect of bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involved

Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,

Journal Article