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Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 356-362 doi: 10.1007/s11684-010-0220-5

Abstract: Acute myeloid leukemia (AML) is a very heterogeneous neoplasm of the hematopoietic stem cell.categories, class I mutations that confer a proliferation advantage and class II mutations that inhibit myeloid

Keywords： acute myeloid leukemia     mutations     risk stratification    

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FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 896-908 doi: 10.1007/s11684-022-0944-z

Abstract: Hence, we aimed to explore its definite role in the development of acute myeloid leukemia (AML) and emphasize

Keywords： acute myeloid leukemia     FGF13     prognosis     immune-related genes     bone marrow niches    

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expression pattern of mutations coordinated by target repression and promoter hypermethylation in acutemyeloid leukemia

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Its dysfunction, caused by either fusions or mutations, is frequently reported in acute myeloid leukemia

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 685-698 doi: 10.1007/s11684-022-0942-1

Abstract: However, little is known about the role of ACSL5 in acute myeloid leukemia (AML).

Keywords： acute myeloid leukemia     acyl-CoA synthetase long chain family member 5     Wnt3a     palmitoylation     ABT-199    

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Chimeric antigen receptor T cell therapies for acute myeloid leukemia

Bin Gu, Jianhong Chu, Depei Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 701-710 doi: 10.1007/s11684-020-0763-z

Abstract: Acute myeloid leukemia (AML) is a group of heterogeneous myeloid malignancies.Allogeneic hematopoietic stem cell transplantation could be an effective therapy because of the graft-versus-leukemia

Keywords： acute myeloid leukemia     CAR T     immunotherapy    

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Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of

Zhan Su, Fengyu Wu, Weiyu Hu, Xiaodan Liu, Shaoling Wu, Xianqi Feng, Zhongguang Cui, Jie Yang, Zhenguang Wang, Hongzai Guan, Hongguo Zhao, Wei Wang, Chunting Zhao, Jun Peng

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 440-444 doi: 10.1007/s11684-017-0523-x

Abstract:

Philadelphia chromosome-positive acute myeloid leukemia is controversial and difficult to distinguishfrom the blast phase of chronic myeloid leukemia.As a myeloid neoplasm, rare cases of this leukemia manifest multiple soft-tissue tumors or bone lyticBCR-ABL1 fusion gene together with complex chromosome abnormalities, a diagnosis of Philadelphia-positive acutemyeloid leukemia was made, although the type (de novo or blast crisis) remained unclear.

Keywords： Philadelphia chromosome     acute myeloid leukemia     mass     osteolysis     positron emission tomography    

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Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloidleukemia: a case report

Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 593-599 doi: 10.1007/s11684-018-0635-y

Abstract: p>Conventional combination therapies have not resulted in considerable progress in the treatment of acutemyeloid leukemia (AML).BCL-2 inhibitor, has been approved for the treatment of relapsed and/or refractory chronic lymphoid leukemia

Keywords： venetoclax     cytarabine     AML     leukemia    

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Homoharringtonine is a safe and effective substitute for anthracyclines in children younger than 2 years old with acutemyeloid leukemia

Xiaoxiao Chen, Yanjing Tang, Jing Chen, Ru Chen, Longjun Gu, Huiliang Xue, Ci Pan, Jingyan Tang, Shuhong Shen

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 378-387 doi: 10.1007/s11684-018-0658-4

Abstract: , exhibits a unique anticancer mechanism and has been widely used in China to treat patients with acutemyeloid leukemia (AML) since the 1970s.From February 2009 to November 2015, 59 patients less than 2 years old with AML (other than acute promyelocyticleukemia) were recruited.

Keywords： homoharringtonine     acute myeloid leukemia     pediatrics    

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methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia

Yuting Tan,Han Liu,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 412-420 doi: 10.1007/s11684-015-0423-x

Abstract:

Genetic mutations are considered to drive the development of acute myeloid leukemia (AML).mutations alone may only transform hematopoietic stem cells into pre-LSCs without causing the full-blown leukemia

Keywords： preleukemic stem cell     acute myeloid leukemia     relapse     DNMT3A    

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Prognostic analysis of chronic myeloid leukemia in Chinese population in an imatinib era

Haiyan He, Yang Shen, Yongmei Zhu, Saijuan Chen

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 204-211 doi: 10.1007/s11684-012-0202-x

Abstract:

We evaluated the outcomes of chronic myeloid leukemia (CML) patients in three clinical phases, namely

Keywords： imatinib     chronic myeloid leukemia     complete cytogenetic response    

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disease after anti-thymocyte globulin-based haploidentical hematopoietic stem cell transplantation in acutemyeloid leukemia

Meng Lv, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang, Xiaodong Mo

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 667-679 doi: 10.1007/s11684-019-0702-z

Abstract: identify the risk factors for cGVHD in patients who underwent anti-thymocyte globulin-based haplo-HSCT for acutemyeloid leukemia ( =280).The patients who had grades III to IV acute GVHD (aGVHD) had higher 8-year incidence of cGVHD (total,

Keywords： acute graft-versus-host disease     chronic graft-versus-host disease     National Institutes of Health consensuscriteria     acute myeloid leukemia     anti-thymocyte globulin    

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Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research

Jiong HU

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 45-52 doi: 10.1007/s11684-011-0117-y

Abstract:

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia.directly degrades the PML-RARα fusion transcript, leading to the differentiation and apoptosis of leukemiacells and the potential eradication of APL leukemia-initiating cells (LICs), thus making the diseasea potentially curable type of leukemia.

Keywords： acute promyelocytic leukemia     arsenic     all-trans retinoic acid     survival    

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Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia

Meilin Ma, Xiang Wang, Jingyan Tang, Huiliang Xue, Jing Chen, Ci Pan, Hua Jiang, Shuhong Shen

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 416-420 doi: 10.1007/s11684-012-0224-4

Abstract:

Acute lymphoblastic leukemia includes T-cell acute lymphoblastic leukemia (T-ALL) and B-cell acutelymphoblastic leukemia (B-ALL).This novel subtype of T-ALL was called early T-cell precursor acute lymphoblastic leukemia (ETP-ALL).between ETP (CD1a-, CD8-, CD5dim, at least one marker of stem cell or myeloidOur findings demonstrate that early T-cell precursor leukemia is a very high-risk subtype of acute lymphoblastic

Keywords： acute lymphoblastic leukemia     early T precursor     prognosis    

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Four-year follow-up of patients with imatinib-resistant or intolerant chronic myeloid leukemia receiving

Xiaojun Huang, Qian Jiang, Jianda Hu, Jianyong Li, Jie Jin, Fanyi Meng, Zhixiang Shen, Ting Liu, Depei Wu, Jianmin Wang, Jianxiang Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 344-353 doi: 10.1007/s11684-018-0639-7

Abstract: Dasatinib is a highly effective second-generation tyrosine kinase inhibitor used to treat chronic myeloidleukemia (CML).

Keywords： chronic myeloid leukemia (CML)     dasatinib     tyrosine kinase inhibitor     long-term follow-up    

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Mutation profiling of 16 candidate genes in

Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 229-237 doi: 10.1007/s11684-018-0616-1

Abstract: This retrospective analysis aimed to investigate the mutation profile of 16 common mutated genes in acutemyeloid leukemia (AML) patients.

Keywords： leukemia     myeloid     acute     gene     mutation    

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Title Author Date Type Operation

Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Journal Article

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Journal Article

expression pattern of mutations coordinated by target repression and promoter hypermethylation in acutemyeloid leukemia

Journal Article

ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Journal Article

Chimeric antigen receptor T cell therapies for acute myeloid leukemia

Bin Gu, Jianhong Chu, Depei Wu

Journal Article

Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of

Zhan Su, Fengyu Wu, Weiyu Hu, Xiaodan Liu, Shaoling Wu, Xianqi Feng, Zhongguang Cui, Jie Yang, Zhenguang Wang, Hongzai Guan, Hongguo Zhao, Wei Wang, Chunting Zhao, Jun Peng

Journal Article

Venetoclax and low-dose cytarabine induced complete remission in a patient with high-risk acute myeloidleukemia: a case report

Bingshan Liu, Roshni Narurkar, Madhura Hanmantgad, Wahib Zafar, Yongping Song, Delong Liu

Journal Article

Homoharringtonine is a safe and effective substitute for anthracyclines in children younger than 2 years old with acutemyeloid leukemia

Xiaoxiao Chen, Yanjing Tang, Jing Chen, Ru Chen, Longjun Gu, Huiliang Xue, Ci Pan, Jingyan Tang, Shuhong Shen

Journal Article

methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia

Yuting Tan,Han Liu,Saijuan Chen

Journal Article

Prognostic analysis of chronic myeloid leukemia in Chinese population in an imatinib era

Haiyan He, Yang Shen, Yongmei Zhu, Saijuan Chen

Journal Article

disease after anti-thymocyte globulin-based haploidentical hematopoietic stem cell transplantation in acutemyeloid leukemia

Meng Lv, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang, Xiaodong Mo

Journal Article

Arsenic in the treatment of newly diagnosed acute promyelocytic leukemia: current status and future research

Jiong HU

Journal Article

Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia

Meilin Ma, Xiang Wang, Jingyan Tang, Huiliang Xue, Jing Chen, Ci Pan, Hua Jiang, Shuhong Shen

Journal Article

Four-year follow-up of patients with imatinib-resistant or intolerant chronic myeloid leukemia receiving

Xiaojun Huang, Qian Jiang, Jianda Hu, Jianyong Li, Jie Jin, Fanyi Meng, Zhixiang Shen, Ting Liu, Depei Wu, Jianmin Wang, Jianxiang Wang

Journal Article

Mutation profiling of 16 candidate genes in

Yang Zhang, Fang Wang, Xue Chen, Wenjing Liu, Jiancheng Fang, Mingyu Wang, Wen Teng, Panxiang Cao, Hongxing Liu

Journal Article