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airway inflammation 2

asthma 2

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airway 1

bronchial hyperresponsiveness 1

gastroesophageal reflux 1

micro-aspiration 1

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particulate matter 2.5 1

peripheral blood lymphocyte 1

pharyngeal nozzle 1

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Particulate matter 2.5 triggers airway inflammation and bronchial hyperresponsiveness in mice by activating

Frontiers of Medicine 2021, Volume 15, Issue 5, Pages 750-766 doi: 10.1007/s11684-021-0839-4

Abstract: Exposure to particulate matter 2.5 (PM2.5) potentially triggers airway inflammation by activating nuclearHowever, the function and specific mechanisms of SIRT2 in PM2.5-induced airway inflammation are largelymechanisms of SIRT2 in regulating the phosphorylation and acetylation of p65 influenced by PM2.5-induced airwayThe activation of p65 triggered airway inflammation, increment of mucus secretion by goblet cells, andMeanwhile, p65 phosphorylation and acetylation, airway inflammation, and bronchial hyperresponsiveness

Keywords： particulate matter 2.5 sirtuin 2 p65 airway inflammation bronchial hyperresponsiveness triptolide

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Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle

Zhonggao Wang,Zhiwei Hu,Jimin Wu,Feng Ji,Hongtao Wang,Yungang Lai,Xiang Gao,Yachan Ning,Chengchao Zhang,Zhitong Li,Weitao Liang,Jianjun Liu

Frontiers of Medicine 2015, Volume 9, Issue 1, Pages 117-122 doi: 10.1007/s11684-014-0343-1

Abstract: time of global paying the highest attention to the worst insults of smoking as well as haze on the airwaymany medical personnel, do not know how badly the gastroesophageal reflux (GER) insults on our own airwayas a nozzle, so as to produce numerous micro-particles and reach the oro-nasal cavity and also the airwayThe GER induced airway challenge is a treatable and preventive entity, as soon as a diagnosis is made

Keywords： gastroesophageal reflux airway pharyngeal nozzle micro-aspiration asthma

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Tim-3 mRNA expression in peripheral blood lymphocytes from asthmatic patients

Xiaoxia LU, Weikun HU, Shengdao XIONG, Guopeng XU, Fen LAN

Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 187-190 doi: 10.1007/s11684-009-0033-6

Abstract: The study aimed to detect the expression of the Th1-specific cell surface protein T cell Ig and mucin domain-containing molecule-3 (Tim-3) mRNA in peripheral blood lymphocytes isolated from asthmatic patients and to examine the correlation among Tim-3 mRNA, interleukin-4 (IL-4), interferon-γ (IFN-γ) level, and FEV1/FVC (force expiratory volume in one second/forced vital capacity) to explore the role of Tim-3 in the development and progression of asthmatic inflammation. Tim-3 mRNA expression was detected by reverse transcription polymerase chain reaction (RT-PCR). The IL-4 and IFN-γ levels were determined by using enzyme-linked immunosorbent assay (ELISA). The correlation among Tim-3 mRNA, IL-4, IFN-γ level, and pulmonary ventilatory capacity was analyzed. The expression of Tim-3 mRNA in patients with acute asthma exacerbation was 0.39±0.06, significantly higher than that in patients at the remission stage and controls (0.18±0.05 and 0.07±0.03, <0.05). The level of IL-4 in patients with acute asthma exacerbation was 68.42±10.54, significantly higher than that in the patients at the remission stage and controls (41.83±9.37 and 32.75±8.16, <0.05). The level of IL-4 in patients in remission was significantly higher than that in controls ( <0.05). The level of IFN-γ in patients with acute asthma exacerbation was 65.74±7.85, significantly lower than that in patients in remission and the control group (120.84±11.62 and 139.65±13.47, <0.05). The level of IFN-γ in patients in asthma remission was significantly lower than that in controls ( <0.05). Tim-3 mRNA expression was positively correlated with the level of IL-4 ( =0.68, <0.05) and negatively with the level of IFN-γ and pulmonary ventilatory capacity ( =-0.85, =-0.76, both <0.01). The increased expression of Tim-3 mRNA in peripheral blood lymphocytes might be involved in the development and progression of asthmatic inflammation.

Keywords： asthma airway inflammation peripheral blood lymphocyte Tim-3