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Prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran

Fatemeh Mehravar,Soheil Rafiee,Behnaz Bazrafshan,Mahmoud Khodadost

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 345-350 doi: 10.1007/s11684-016-0462-y

Abstract: This study aimed to examine the prevalence of asthma symptoms in Golestan schoolchildren aged 6&ndashAsthma symptoms were assessed using the questionnaire of the International Study of Asthma and Allergiessymptoms for each of the gender and age groups.The prevalence rates of “current asthmasymptoms and “asthma ever” in all theThis study shows that the prevalence of the asthma symptoms in boys is lower than that in girls in both

Keywords: asthma     asthma symptoms     epidemiology     childhood     chronic disease    

Lung function and air pollution exposure in adults with asthma in Beijing: a 2-year longitudinal panel

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 574-583 doi: 10.1007/s11684-021-0882-1

Abstract: The effect of air pollution on the lung function of adults with asthma remains unclear to date.This study followed 112 patients with asthma at 3-month intervals for 2 years.to CO and PM2.5 was negatively associated with the large airway function of adults with asthmathan in adults with moderate asthma.Patients with asthma react differently to air pollutants as evidenced by their lung function levels.

Keywords: lung function     asthma     air pollution     adult    

Not asthma, but GERD: case report

WANG Zhonggao

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 115-119 doi: 10.1007/s11684-007-0022-6

Abstract: Asthma is a disorder of the lungs characterized by increased responsiveness of the airways, as manifestedA patient suffered from GERD without esophageal symptoms, which was diagnosed and treated as bronchialasthma during his five emergency admissions.The concept of not asthma, but GERD seems undervalued, unappreciated, even misunderstood among patientswith intractable asthma.

Keywords: resistance     mechanism responsible     unappreciated     responsiveness     different    

Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomized

Ting Liu, Faping Wang, Geng Wang, Hui Mao

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 340-349 doi: 10.1007/s11684-017-0565-0

Abstract: interleukin-5 receptor α to deplete blood eosinophils and improve the clinical outcomes of allergic asthmato evaluate the safety and efficacy of different doses of benralizumab in patients with eosinophilic asthmaAll randomized controlled trials involving benralizumab treatment for patients with eosinophilic asthmapublished until January 2017, as well as the rate of asthmatic exacerbation, pulmonary functionality, asthmas (FEV1), Asthma Quality of Life Questionnaire scores, decreased asthmatic exacerbation and Asthma Control

Keywords: benralizumab     anti-interleukin-5     monoclonal antibody     eosinophilic asthma     meta-analysis    

Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 919-931 doi: 10.1007/s11684-021-0918-6

Abstract: Moreover, in vivo results showed that diannexin could prevent PE-like symptoms by decreasing MPs

Keywords: preeclampsia     recombinant protein diannexin     microparticle     NLRP3 inflammasome     phosphatidylserin    

A belated revelation: from gastroesophageal reflux derived asthma to laryngotracheal irritation even

WANG Zhonggao

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 127-129 doi: 10.1007/s11684-008-0023-0

Abstract: syndromes: reflux cough syndrome, reflux laryngitis syndrome, reflux dental erosion syndrome and the reflux asthmaThe author himself happened to receive five emergency rescue treatments following apparent “bronchial asthmaThe procedure immediately cleared up his “asthma”.The GER-derived asthma is not asthma, but GER pure and simple;2.The pathogenesis of “asthma” is not asthma, but laryngotracheal irritation/spasm and its sequence.

Keywords: laryngotracheal irritation/spasm     gastro-oesophago-laryngo-tracheal     sequence     fundaplication     encouraging    

Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study

Siyi Li, Peilin Lv, Min He, Wenjing Zhang, Jieke Liu, Yao Gong, Ting Wang, Qiyong Gong, Yulin Ji, Su Lui

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 792-801 doi: 10.1007/s11684-020-0745-1

Abstract: Asthma is a serious health problem that involves not only the respiratory system but also the centralPrevious studies identified either regional or network alterations in patients with asthma, but inconsistentare the regional and neural network deficits related or are they two independent characteristics in asthmaBy collecting resting-state functional magnetic resonance imaging from 39 patients with asthma and 40network changes, thereby suggesting that the two parameters reflect different brain characteristics of asthma

Keywords: asthma     brain     regional activation     functional connectivity     resting-state fMRI    

Progress on early diagnosing Alzheimer’s disease

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 446-464 doi: 10.1007/s11684-023-1047-1

Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects both cognition and non-cognition functions. The disease follows a continuum, starting with preclinical stages, progressing to mild cognitive and behavioral impairment, ultimately leading to dementia. Early detection of AD is crucial for better diagnosis and more effective treatment. However, the current AD diagnostic tests of biomarkers using cerebrospinal fluid and/or brain imaging are invasive or expensive, and mostly are still not able to detect early disease state. Consequently, there is an urgent need to develop new diagnostic techniques with higher sensitivity and specificity during the preclinical stages of AD. Various non-cognitive manifestations, including behavioral abnormalities, sleep disturbances, sensory dysfunctions, and physical changes, have been observed in the preclinical AD stage before occurrence of notable cognitive decline. Recent research advances have identified several biofluid biomarkers as early indicators of AD. This review focuses on these non-cognitive changes and newly discovered biomarkers in AD, specifically addressing the preclinical stages of the disease. Furthermore, it is of importance to explore the potential for developing a predictive system or network to forecast disease onset and progression at the early stage of AD.

Keywords: Alzheimer’s disease     early diagnosis     non-cognitive symptoms     biomarkers    

Outcome of Stretta radiofrequency and fundoplication for GERD-related severe asthmatic symptoms

Zhiwei Hu,Jimin Wu,Zhonggao Wang,Yu Zhang,Weitao Liang,Chao Yan

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 437-443 doi: 10.1007/s11684-015-0422-y

Abstract: A total of 137 gastroesophageal reflux disease (GERD) patients with severe asthmatic symptoms who respondedinadequately to medical treatment for asthma were investigated.A questionnaire covering 29 related symptoms and medication use was employed.asthmatic and ENT symptoms, with better outcomes exhibited by the LNF group.Severe asthmatic symptoms and GERD were closely associated, and this finding warrants further study.

Keywords: asthma     gastroesophageal reflux     Stretta radiofrequency     laparoscopic Nissen fundoplication    

A giant Müllerian duct cyst in the perineum: a case report

Xianghu Meng, Jihong Liu, Xiao Yu, Shaogang Wang, Cong Liu, Zhangqun Ye

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 440-443 doi: 10.1007/s11684-012-0222-6

Abstract: Treatments of Müllerian duct cysts depend on their sizes and symptoms.

Keywords: Müllerian duct cyst     clinical symptoms     diagnosis    

Gastric Mucosal Microbiota in Patients with Liver Cirrhosis and Its Associations with Gastrointestinal Symptoms Article

Yanfei Chen, Jing Guo, Chunlei Chen, Ding Shi, Daiqiong Fang, Feng Ji, Lanjuan Li

Engineering 2021, Volume 7, Issue 4,   Pages 507-514 doi: 10.1016/j.eng.2020.04.014

Abstract: Patients in Cluster_2 had more severe gastrointestinal symptoms and a higher rate of previous endoscopiclead to a distinct structure of the gastric mucosal microbiota, thus aggravating the gastrointestinal symptoms

Keywords: Microbiome     Liver cirrhosis     Symptoms     Varices     Gastric endoscopy    

Characterization of hidden rules linking symptoms and selection of acupoint using an artificial neural

Won-Mo Jung, In-Soo Park, Ye-Seul Lee, Chang-Eop Kim, Hyangsook Lee, Dae-Hyun Hahm, Hi-Joon Park, Bo-Hyoung Jang, Younbyoung Chae

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 112-120 doi: 10.1007/s11684-017-0582-z

Abstract: The pattern recognition process that pertains to symptoms and diseases and informs acupuncture treatmentThe relationship between symptoms and selected acupoints could be systematically characterized through

Keywords: acupuncture     indication     neural network     pattern identification     prediction    

Tim-3 mRNA expression in peripheral blood lymphocytes from asthmatic patients

Xiaoxia LU, Weikun HU, Shengdao XIONG, Guopeng XU, Fen LAN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 187-190 doi: 10.1007/s11684-009-0033-6

Abstract: The expression of Tim-3 mRNA in patients with acute asthma exacerbation was 0.39±0.06, significantlyThe level of IL-4 in patients with acute asthma exacerbation was 68.42±10.54, significantly higher thanThe level of IFN-γ in patients with acute asthma exacerbation was 65.74±7.85, significantly lower thanThe level of IFN-γ in patients in asthma remission was significantly lower than that in controls ( <0.05

Keywords: asthma     airway inflammation     peripheral blood lymphocyte     Tim-3    

Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle

Zhonggao Wang,Zhiwei Hu,Jimin Wu,Feng Ji,Hongtao Wang,Yungang Lai,Xiang Gao,Yachan Ning,Chengchao Zhang,Zhitong Li,Weitao Liang,Jianjun Liu

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 117-122 doi: 10.1007/s11684-014-0343-1

Abstract: Symptoms of GER are commonly seen as heartburn and regurgitation, which can be mostly tolerated.Zhonggao Wang had suffered it for long and symptoms disappeared for 8 years after anti-reflux surgery

Keywords: gastroesophageal reflux     airway     pharyngeal nozzle     micro-aspiration     asthma    

Symptom network topological features predict the effectiveness of herbal treatment for pediatric cough

Mengxue Huang, Jingjing Wang, Runshun Zhang, Zhuying Ni, Xiaoying Liu, Wenwen Liu, Weilian Kong, Yao Chen, Tiantian Huang, Guihua Li, Dan Wei, Jianzhong Liu, Xuezhong Zhou

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 357-367 doi: 10.1007/s11684-019-0699-3

Abstract: Pediatric cough is a heterogeneous condition in terms of symptoms and the underlying disease mechanismsThis study aims to investigate whether the network structure of pediatric cough symptoms is associatedof patients with pediatric cough are related to the effectiveness of treatment: a dense network of symptomsInterventions with the most different symptoms in the symptom network may have improved therapeutic effects

Keywords: pediatric cough     complex network     symptoms     traditional Chinese medicine     electronic medical records    

Title Author Date Type Operation

Prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran

Fatemeh Mehravar,Soheil Rafiee,Behnaz Bazrafshan,Mahmoud Khodadost

Journal Article

Lung function and air pollution exposure in adults with asthma in Beijing: a 2-year longitudinal panel

Journal Article

Not asthma, but GERD: case report

WANG Zhonggao

Journal Article

Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomized

Ting Liu, Faping Wang, Geng Wang, Hui Mao

Journal Article

Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing

Journal Article

A belated revelation: from gastroesophageal reflux derived asthma to laryngotracheal irritation even

WANG Zhonggao

Journal Article

Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study

Siyi Li, Peilin Lv, Min He, Wenjing Zhang, Jieke Liu, Yao Gong, Ting Wang, Qiyong Gong, Yulin Ji, Su Lui

Journal Article

Progress on early diagnosing Alzheimer’s disease

Journal Article

Outcome of Stretta radiofrequency and fundoplication for GERD-related severe asthmatic symptoms

Zhiwei Hu,Jimin Wu,Zhonggao Wang,Yu Zhang,Weitao Liang,Chao Yan

Journal Article

A giant Müllerian duct cyst in the perineum: a case report

Xianghu Meng, Jihong Liu, Xiao Yu, Shaogang Wang, Cong Liu, Zhangqun Ye

Journal Article

Gastric Mucosal Microbiota in Patients with Liver Cirrhosis and Its Associations with Gastrointestinal Symptoms

Yanfei Chen, Jing Guo, Chunlei Chen, Ding Shi, Daiqiong Fang, Feng Ji, Lanjuan Li

Journal Article

Characterization of hidden rules linking symptoms and selection of acupoint using an artificial neural

Won-Mo Jung, In-Soo Park, Ye-Seul Lee, Chang-Eop Kim, Hyangsook Lee, Dae-Hyun Hahm, Hi-Joon Park, Bo-Hyoung Jang, Younbyoung Chae

Journal Article

Tim-3 mRNA expression in peripheral blood lymphocytes from asthmatic patients

Xiaoxia LU, Weikun HU, Shengdao XIONG, Guopeng XU, Fen LAN

Journal Article

Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle

Zhonggao Wang,Zhiwei Hu,Jimin Wu,Feng Ji,Hongtao Wang,Yungang Lai,Xiang Gao,Yachan Ning,Chengchao Zhang,Zhitong Li,Weitao Liang,Jianjun Liu

Journal Article

Symptom network topological features predict the effectiveness of herbal treatment for pediatric cough

Mengxue Huang, Jingjing Wang, Runshun Zhang, Zhuying Ni, Xiaoying Liu, Wenwen Liu, Weilian Kong, Yao Chen, Tiantian Huang, Guihua Li, Dan Wei, Jianzhong Liu, Xuezhong Zhou

Journal Article