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Sodium cellulose sulfate: A promising biomaterial used for microcarriers’ designing

Qing-Xi Wu, Yi-Xin Guan, Shan-Jing Yao

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 1, Pages 46-58 doi: 10.1007/s11705-018-1723-x

Abstract: Due to a worldwide focus on sustainable materials for human health and economy services, more and more natural renewable biomass are regarded as promising materials that could replace synthetic polymers and reduce global dependence on petroleum resources. Cellulose is known as the most abundant renewable polymer in nature, varieties of cellulose-based products have been developed and have gained growing interest in recent years. In this review, a kind of water-soluble cellulose derivative, i.e., sodium cellulose sulfate (NaCS) is introduced. Details about NaCS’s physicochemical properties like solubility, biocompatibility, biodegradability, degree of substitution, etc. are systematically elaborated. And promising applications of NaCS used as biomaterials for microcarriers’ designing, such as micro-cell-carriers, micro-drug-carriers, etc., are presented.

Keywords： sodium cellulose sulfate biomaterial physicochemical properties microcarriers

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Combination of biomaterial transplantation and genetic enhancement of intrinsic growth capacities to

Bin Yu, Xiaosong Gu

Frontiers of Medicine 2019, Volume 13, Issue 2, Pages 131-137 doi: 10.1007/s11684-018-0642-z

Abstract: To circumvent these barriers, biomaterial scaffolds are applied to bridge the lesion gaps for the regrowingGiven the complex pathophysiology of SCI, combining biomaterial scaffolds and genetic manipulation may

Keywords： spinal cord injury biomaterial extrinsic barrier intrinsic regeneration capacity

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Application of Biomaterials in Cardiac Repair and Regeneration Review

Zhi Cui,Baofeng Yang,Ren-Ke Li

Engineering 2016, Volume 2, Issue 1, Pages 141-148 doi: 10.1016/J.ENG.2016.01.028

Abstract:

Cardiovascular disease is a leading cause of death throughout the world. The demand for new therapeutic interventions is increasing. Although pharmacological and surgical interventions dramatically improve the quality of life of cardiovascular disease patients, cheaper and less invasive approaches are always preferable. Biomaterials, both natural and synthetic, exhibit great potential in cardiac repair and regeneration, either as a carrier for drug delivery or as an extracellular matrix substitute scaffold. In this review, we discuss the current treatment options for several cardiovascular diseases, as well as types of biomaterials that have been investigated as potential therapeutic interventions for said diseases. We especially highlight investigations into the possible use of conductive polymers for correcting ischemic heart disease-induced conduction abnormalities, and the generation of biological pacemakers to improve the conduction pathway in heart block.

Keywords： Myocardial infarction Heart regeneration Biomaterial Tissue engineering Stem cell

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Microfluidics for Medical Additive Manufacturing Review

Jie Wang, Changmin Shao, Yuetong Wang, Lingyun Sun, Yuanjin Zhao

Engineering 2020, Volume 6, Issue 11, Pages 1244-1257 doi: 10.1016/j.eng.2020.10.001

Abstract:

Additive manufacturing plays a vital role in the food, mechanical, pharmaceutical, and medical fields. Within these fields, medical additive manufacturing has led to especially obvious improvements in medical instruments, prostheses, implants, and so forth, based on the advantages of cost-effectiveness, customizability, and quick manufacturing. With the features of precise structural control, high throughput, and good component manipulation, microfluidic techniques present distinctive benefits in medical additive manufacturing and have been applied in the areas of drug discovery, tissue engineering, and organs on chips. Thus, a comprehensive review of microfluidic techniques for medical additive manufacturing is useful for scientists with various backgrounds. Herein, we review recent progress in the development of microfluidic techniques for medical additive manufacturing. We evaluate the distinctive benefits associated with microfluidic technologies for medical additive manufacturing with respect to the fabrication of droplet/fiber templates with different structures. Extensive applications of microfluidic techniques for medical additive manufacturing are emphasized, such as cell guidance, three-dimensional (3D) cell culture, tissue assembly, and cell-based therapy. Finally, we present challenges in and future perspectives on the development of microfluidics for medical additive manufacturing.

Keywords： Microfluidics Biomaterial Additive manufacturing Droplet Fiber

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Rise of the Liquid Metal Science, Technology and Industry: Advancements and Opportunities

Liu Jing

Strategic Study of CAE 2020, Volume 22, Issue 5, Pages 93-103 doi: 10.15302/J-SSCAE-2020.05.016

Abstract:

The room temperature liquid metal and its allied materials are a class of emerging functional matters with diverse species. Recently, with breakthrough discoveries made on liquid metals, tremendous exciting applications were raised and many new materials that had never been anticipated before were invented. As a result, the latest achievements on liquid metals were ascribed as the second revolution of human beings over the process of utilizing metals. This article briefly summarized typical advancements, fundamental sciences, and key technological and industrial areas thus initiated which include but are not limited to: chip cooling and energy utilization, printed electronics and 3D printing, biomedical materials, as well as smart soft machines. In addition, historic background to propose and establish “The China Liquid Metal Valley” and the basic strategy to mold a brand new industry of liquid metal were outlined. The core values to strengthen future research on liquid metal material genome engineering and thus build up corresponding databases were summarized. Overall, liquid metals are important frontiers for science, technology, and industry integrating both fundamental and practical issues together. Further continuous endeavors would lead to pivotal progress of human civilization and thus reshape social production and lifestyle. Its impact for both China and the world to explore next generation revolutionary science, technology, and industry will be huge.

Keywords： liquid metal new material disruptive technology new industry advanced cooling printed electronics biomaterial

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Surface modification of biomaterials by photochemical immobilization and photograft polymerization to improve hemocompatibility

Yakai FENG, Haiyang ZHAO, Li ZHANG, Jintang GUO,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 3, Pages 372-381 doi: 10.1007/s11705-010-0005-z

Abstract: Three approaches to modify biomaterial surfaces for improving the hemocompatibility, i.e., bioinert surfaces

Keywords： biomimetic amphiphilic amphiphilic phosphorylcholine endothelial functional biomaterial

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Microfluidic Generation of Multicomponent Soft Biomaterials Review

Yuetong Wang, Luoran Shang, Yuanjin Zhao, Lingyun Sun

Engineering 2022, Volume 13, Issue 6, Pages 128-143 doi: 10.1016/j.eng.2021.02.026

Abstract:

Soft biomaterials hold great potential for a plethora of biomedical applications because of their deformability, biodegradability, biocompatibility, high bioactivity, and low antigenicity. Multicomponent soft biomaterials are particularly attractive as a way of accommodating components made of different materials and generating combinative functions. Microfluidic technology has emerged as an outstanding tool in generating multicomponent materials with elaborate structures and constituents, in that it can manipulate multiphasic flows precisely on the micron scale. In recent decades, much progress has been achieved in the microfluidic fabrication of multicomponent soft biomaterials with finely defined physicochemical properties capable of controllable therapeutics delivery, three-dimensional (3D) cell culture, flexible devices and wearable electronics, and biosensing for molecules. In the paper, we summarize current progress in multicomponent soft biomaterials derived from microfluidics and emphasize their applications in biomedical fields. We also provide an outlook of the remaining challenges and future trends in this field.

Keywords： Soft biomaterial Microfluidics Multicomponent Microparticle Microfiber

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A Brief Summary of Current Therapeutic Strategies for Spinal Cord Injury Review

Chun Yao, Xin Tang, Yuqi Cao, Xuhua Wang, Bin Yu

Engineering 2022, Volume 13, Issue 6, Pages 46-52 doi: 10.1016/j.eng.2021.07.018

Abstract: progress that has been made in SCI repair based on the lesion microenvironment, neural circuits, and biomaterial

Keywords： Spinal cord injury Microenvironment Neural circuits Biomaterial scaffolds

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Wang Yingjun: Biomaterial Research Technology (2018-6-2)

24 May 2021

Keywords：医学

Hierarchically Inverse Opal Porous Scaffolds from Droplet Microfluidics for Biomimetic 3D Cell Co-Culture Article

Changmin Shao, Yuxiao Liu, Junjie Chi, Fangfu Ye, Yuanjin Zhao

Engineering 2021, Volume 7, Issue 12, Pages 1778-1785 doi: 10.1016/j.eng.2020.06.031

Abstract:

With the advantages of better mimicking the specificity of natural tissues, three-dimensional (3D) cell culture plays a major role in drug development, toxicity testing, and tissue engineering. However, existing scaffolds or microcarriers for 3D cell culture are often limited in size and show suboptimal performance in simulating the vascular complexes of living organisms. Therefore, we present a novel hierarchically inverse opal porous scaffold made via a simple microfluidic approach for promoting 3D cell co-culture techniques. The designed scaffold is constructed using a combined concept involving an emulsion droplet template and inert polymer polymerization. This work demonstrates that the resultant scaffolds ensure a sufficient supply of nutrients during cell culture, so as to achieve large-volume cell culture. In addition, by serially planting different cells in the scaffold, a 3D co-culture system of endothelial-cell-encapsulated hepatocytes can be developed for constructing certain functional tissues. It is also demonstrated that the use of the proposed scaffold for a co-culture system helps hepatocytes to maintain specific in vivo functions. These hierarchically inverse opal scaffolds lay the foundation for 3D cell culture and even the construction of biomimetic tissues.

Keywords： Microfluidics Inverse opal Cell culture Droplet Biomaterial

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Jingming Gao, Xiaoye Yu, Xinlei Wang, Yingning He, Jiandong Ding

Engineering 2022, Volume 13, Issue 6, Pages 31-45 doi: 10.1016/j.eng.2021.11.025

Abstract: This review focuses on six aspects of biomaterial-related cell microenvironments: ① chemical composition

Keywords： Tissue engineering Regenerative medicine Biomaterials Cell microenvironment Porous scaffold Surface patterning Cell-material interactions

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A Micro Peristaltic Pump Using an Optically Controllable Bioactuator Article

Eitaro Yamatsuta, Sze Ping Beh, Kaoru Uesugi, Hidenobu Tsujimura, Keisuke Morishima

Engineering 2019, Volume 5, Issue 3, Pages 580-585 doi: 10.1016/j.eng.2018.11.033

Abstract:

Peristalsis is widely seen in nature, as this pumping action is important in digestive systems for conveying sustenance to every corner of the body. In this paper, we propose a muscle-powered tubular micro pump that provides peristaltic transport. We utilized Drosophila melanogaster larvae that express channelrhodopsin-2 (ChR2) on the cell membrane of skeletal muscles to obtain light-responsive muscle tissues. The larvae were forced to contract with blue light stimulation. While changing the speed of the propagating light stimulation, we observed displacement on the surface of the contractile muscle tissues. We obtained peristaltic pumps from the larvae by dissecting them into tubular structures. The average inner diameter of the tubular structures was about 400 μm and the average outer diameter was about 750 μm. Contractions of this tubular structure could be controlled with the same blue light stimulation. To make the inner flow visible, we placed microbeads into the peristaltic pump, and thus determined that the pump could transport microbeads at a speed of 120 μm·s⁻¹.

Keywords： Tubular structure Bioactuator Peristaltic pump Optogenetics Biomaterial Muscle actuator Tissue engineered

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Quality Monitoring of Porous Zein Scaffolds: A Novel Biomaterial

Yue Zhang, Wei-Ying Li, Run Lan, Jin-Ye Wang

Engineering 2017, Volume 3, Issue 1, Pages 130-135 doi: 10.1016/J.ENG.2017.01.001

Abstract:

Our previous studies have shown that zein has good biocompatibility and good mechanical properties. The first product from a porous scaffold of zein, a resorbable bone substitute, has passed the biological evaluation of medical devices (ISO 10993) by the China Food and Drug Administration. However, Class III medical devices need quality monitoring before being placed on the market, and such monitoring includes quality control of raw materials, choice of sterilization method, and evaluation of biocompatibility. In this paper, we investigated four sources of zein through amino acid analysis (AAA) and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) in order to monitor the composition and purity, and control the quality of raw materials. We studied the effect of three kinds of sterilization method on a porous zein scaffold by SDS-PAGE. We also compared the changes in SDS-PAGE patterns when irradiated with different doses of gamma radiation. We found that polymerization or breakage did not occur on peptide chains of zein during gamma-ray (γ-ray) sterilization in the range of 20–30 kGy, which suggested that γ-ray sterilization is suitable for porous zein scaffolds. Regarding cell compatibility, we found a difference between using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and a cell-counting kit-8 (CCK-8) assay to assess cell proliferation on zein film, and concluded that the CCK-8 assay is more suitable, due to its low background optical density.

Keywords： Zein Amino acid analysis SDS-PAGE Gamma-ray sterilization MTT assay CCK-8 assay