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Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine

Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 157-162 doi: 10.1007/s11684-011-0128-8

Abstract: At present, clinical pathway has become one of the most important health care reform measures in manyIn this study, the authors introduced basic concepts and explored the application of the clinical pathwaySuch concepts provide examples and experiences, on which the application of clinical pathway in Chinese

Keywords： evidence-based medicine     clinical pathway     methodology     concept     technical difficulty    

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Physiological functions and clinical implications of the N-end rule pathway

Yujiao Liu,Chao Liu,Wen Dong,Wei Li

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 258-270 doi: 10.1007/s11684-016-0458-7

Abstract:

The N-end rule pathway is a unique branch of the ubiquitin-proteasome system in which the determinationThe molecular basis of the N-end rule pathway has been elucidated and its physiological functions haveDisturbance of this pathway often causes the failure of these processes, resulting in some human diseasesThis review summarized the physiological functions of the N-end rule pathway, introduced the relatedbiological processes and diseases, with an emphasis on the inner link between this pathway and certain

Keywords： N-end rule pathway     Ate1     cardiovascular development     neurogenesis     spermatogenesis     neurodegenerative disorders    

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Low-temperature caproate production, microbial diversity, and metabolic pathway in xylose anaerobic fermentation

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 3, doi: 10.1007/s11783-023-1637-9

Abstract:

● Converting xylose to caproate under a low temperature of 20 °C by MCF was verified.

Keywords： Xylose fermentation     Caproate     Low temperature     Bifidobacterium     FAB pathway     RBO pathway    

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FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Frontiers of Medicine   Pages 714-728 doi: 10.1007/s11684-022-0959-5

Abstract: FRMD6 interacts and colocalizes with mTOR and S6K, which are the key molecules of the mTOR signaling pathwayFurthermore, knocking out FRMD6 inhibits the activation of the mTOR signaling pathway in Frmd6our results show that FRMD6 contributes to lung cancer progression by activating the mTOR signaling pathway

Keywords： FRMD6     lung cancer     mTOR pathway    

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Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 403-409 doi: 10.1007/s11684-017-0522-y

Abstract:

Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation

Keywords： arterial thrombosis     conditional knockout mice     tissue factor pathway inhibitor     vascular smooth muscle    

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Clinical applications of neurolinguistics in neurosurgery

Peng Wang, Zehao Zhao, Linghao Bu, Nijiati Kudulaiti, Qiao Shan, Yuyao Zhou, N. U. Farrukh Hameed, Yangming Zhu, Lei Jin, Jie Zhang, Junfeng Lu, Jinsong Wu

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 562-574 doi: 10.1007/s11684-020-0771-z

Abstract: The protection of language function is one of the major challenges of brain surgery. Over the past century, neurosurgeons have attempted to seek the optimal strategy for the preoperative and intraoperative identification of language-related brain regions. Neurosurgeons have investigated the neural mechanism of language, developed neurolinguistics theory, and provided unique evidence to further understand the neural basis of language functions by using intraoperative cortical and subcortical electrical stimulation. With the emergence of modern neuroscience techniques and dramatic advances in language models over the last 25 years, novel language mapping methods have been applied in the neurosurgical practice to help neurosurgeons protect the brain and reduce morbidity. The rapid advancements in brain–computer interface have provided the perfect platform for the combination of neurosurgery and neurolinguistics. In this review, the history of neurolinguistics models, advancements in modern technology, role of neurosurgery in language mapping, and modern language mapping methods (including noninvasive neuroimaging techniques and invasive cortical electroencephalogram) are presented.

Keywords： neurolinguistics     language mapping     dual pathway model     neurosurgery    

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Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 637-650 doi: 10.1007/s11684-021-0864-3

Abstract: Further evidence suggested that the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway

Keywords： apigenin     aminoglycosides     ototoxicity     oxidative stress     Nrf2 signaling pathway    

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Biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus

Xiaoxuan Zhu,Xinyi Zeng,Chao Sun,Shilin Chen

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 285-293 doi: 10.1007/s11684-014-0350-2

Abstract: Here we review the recent advances in the biosynthetic pathway of terpenoid indole alkaloids (TIAs) inSecologanin is derived from terpenoid (isoprenoid) biosynthetic pathway, while tryptamine is derivedfrom indole biosynthetic pathway.Although many genes and corresponding enzymes have been characterized in this pathway, our knowledgeon the whole TIA biosynthetic pathway still remains largely unknown up to date.

Keywords： Catharanthus roseus     terpenoidindole alkaloids     biosynthetic pathway     vinblastine     vincristine    

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Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

Chunquan Cai, Ouyan Shi

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 68-78 doi: 10.1007/s11684-014-0308-4

Abstract: The planar cell polarity (PCP) pathway controls the process of convergent extension (CE) during gastrulationThis review summarizes the cumulative results of recent studies on PCP signaling pathway and human NTDs

Keywords： planar cell polarity     neural tube defects     rare mutations    

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NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 263-274 doi: 10.1007/s11684-022-0935-0

Abstract: Herein, we found that NETO2 expression was augmented in melanoma clinical tissues and associated withof calcium ions (Ca2+) and the expression of key genes involved in the calcium signaling pathway

Keywords： melanoma     neuropilin and tolloid-like 2     Ca2+/CaMKII signaling pathway    

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Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 688-696 doi: 10.1007/s11684-018-0662-8

Abstract: an effective drug for T2DM by ameliorating insulin resistance and regulating the PI3K/Akt signaling pathway

Keywords： XKQ     type 2 diabetes mellitus     KKAy mice     PI3K/Akt pathway     diabetic liver disease    

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Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 358-361 doi: 10.1007/s11684-014-0348-9

Abstract:

This study proposes the ontological reconstruction of the current clinical terminology of traditionalof preliminary work related to the said reconstruction, including the ontology-based analysis of TCM clinicalWe conclude that the ontological reconstruction of TCM clinical terminology provides a proper translation

Keywords： ontology     traditional Chinese medicine     clinical terminology    

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Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 216-228 doi: 10.1007/s11684-008-0042-x

Abstract: -catenin signaling pathway has been identified as a key cellular pathway in embryogenesis and diseaseobserved and their exact functions approached, thus ensuring the most complicated understanding of this pathwayIn hepatocellular carcinoma (HCC), with a deeply understanding of this pathway, more and more genes which-catenin signaling pathway has recently been identified and their exact roles in HCC pursued.In this review, we will focus on a mostly updated understanding of this pathway and its observed role

Keywords： interacting     complicated understanding     embryogenesis     activation     organism development    

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 527-533 doi: 10.1007/s11684-022-0967-5

Abstract: In this study, we aim to elucidate the clinical impact and long-term course of tricuspid regurgitation

Keywords： orthotopic heart transplant     tricuspid regurgitation     clinical impact     biatrial heart transplantation    

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Title Author Date Type Operation

Exploring the methodology and application of clinical pathway in evidence-based Chinese medicine

Sicheng Wang, He Yu, Jianping Liu, Baoyan Liu

Journal Article

Physiological functions and clinical implications of the N-end rule pathway

Yujiao Liu,Chao Liu,Wen Dong,Wei Li

Journal Article

Low-temperature caproate production, microbial diversity, and metabolic pathway in xylose anaerobic fermentation

Journal Article

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Journal Article

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

Jichun Yang, Kaiyue Jin, Jiajun Xiao, Jing Ma, Duan Ma

Journal Article

Clinical applications of neurolinguistics in neurosurgery

Peng Wang, Zehao Zhao, Linghao Bu, Nijiati Kudulaiti, Qiao Shan, Yuyao Zhou, N. U. Farrukh Hameed, Yangming Zhu, Lei Jin, Jie Zhang, Junfeng Lu, Jinsong Wu

Journal Article

Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair

Journal Article

Biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus

Xiaoxuan Zhu,Xinyi Zeng,Chao Sun,Shilin Chen

Journal Article

Genetic evidence in planar cell polarity signaling pathway in human neural tube defects

Chunquan Cai, Ouyan Shi

Journal Article

NETO2 promotes melanoma progression via activation of the Ca/CaMKII signaling pathway

Journal Article

Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Journal Article

Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Journal Article

Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma

ZHANG Xufeng, YU Liang, LU Yi

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Journal Article