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Astrocytes in depression and Alzheimer’s disease

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 829-841 doi: 10.1007/s11684-021-0875-0

Abstract: clinical cases, multiple chronic brain diseases may cause psychosocial and cognitive impairment, such as depressionFor years, complex pathological conditions driven by depression and AD have been widely perceived toInterestingly, correlational research on depression and AD has shown that depression might be a prodromeMounting evidence has shown that astrocytic dysfunction is involved in the progression of depressionherein review the current findings on the roles and mechanisms of astrocytes in the development of depression

Keywords： astrocytes     depression     Alzheimer’s disease     roles     mechanisms    

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Type 2 diabetes is causally associated with depression: a Mendelian randomization analysis

Liping Xuan, Zhiyun Zhao, Xu Jia, Yanan Hou, Tiange Wang, Mian Li, Jieli Lu, Yu Xu, Yuhong Chen, Lu Qi, Weiqing Wang, Yufang Bi, Min Xu

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 678-687 doi: 10.1007/s11684-018-0671-7

Abstract:

Type 2 diabetes (T2D) has been associated with a high prevalence of depression.The T2D_GRS was found to be associated with depression with an OR of 1.21 (95% CI: 1.07–1.37) after adjustmentsT2D_GRS as the IV, we similarly found a causal relationship between genetically determined T2D and depressionThough we found no association between the combined effect of the genetic IVs for T2D and depressionwith Egger MR (OR: 0.95, 95% CI: 0.42–2.14), we found an association for T2D and depression with IVW

Keywords： causal modeling     depression     Mendelian randomization     type 2 diabetes    

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Association of maternal depression with dietary intake, growth, and development of preterm infants: a

Han Wang, Hong Zhou, Yan Zhang, Yan Wang, Jing Sun

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 533-541 doi: 10.1007/s11684-017-0591-y

Abstract:

This study aimed to explore the association of maternal depression with nutrient intake, growth, and(64), non-depression-preterm (70), depression-fullterm (36), and depression-preterm (31).A multivariate analysis was used to evaluate the effects of maternal depression and preterm birth onThe energy, protein, and carbohydrate intake in the depression group was lower than the recommended amountsThe depression preterm groups indicated the lowest Z-scores for length and weight and the lowest Bayley-III

Keywords： maternal depression     preterm     infant     nutrition     growth     development    

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Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 729-746 doi: 10.1007/s11684-022-0978-2

Abstract: The effect of anti-programmed cell death 1 (anti-PD-1) immunotherapy is limited in patients with hepatocellular carcinoma (HCC). Yes-associated protein 1 (YAP1) expression increased in liver tumor cells in early HCC, and Akkermansia muciniphila abundance decreased in the colon. The response to anti-PD-1 treatment is associated with A. muciniphila abundance in many tumors. However, the interaction between A. muciniphila abundance and YAP1 expression remains unclear in HCC. Here, anti-PD-1 treatment decreased A. muciniphila abundance in the colon, but increased YAP1 expression in the tumor cells by mice with liver tumors in situ. Mechanistically, hepatocyte-specific Yap1 knockout (Yap1LKO) maintained bile acid homeostasis in the liver, resulting in an increased abundance of A. muciniphila in the colon. Yap1 knockout enhanced anti-PD-1 efficacy. Therefore, YAP1 inhibition is a potential target for increasing A. muciniphila abundance to promote anti-PD-1 efficacy in liver tumors. Dihydroartemisinin (DHA), acting as YAP1 inhibitor, increased A. muciniphila abundance to sensitize anti-PD-1 therapy. A. muciniphila by gavage increased the number and activation of CD8+ T cells in liver tumor niches during DHA treatment or combination with anti-PD-1. Our findings suggested that the combination anti-PD-1 with DHA is an effective strategy for liver tumor treatment.

Keywords： hepatocellular carcinoma     YAP1     Akkermansia muciniphila     anti-PD-1     dihydroartemisinin     bile acid    

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Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 227-239 doi: 10.1007/s11684-021-0896-8

Abstract: adult hippocampal neurogenesis (AHN), whereas promoting AHN can increase stress resilience against depressionThe nonpsychoactive phytocannabinoid cannabidiol (CBD) has been shown to be effective against depressionThese results revealed a previously unknown neural mechanism for neural differentiation and AHN in depression

Keywords： cannabidiol     depression     radial neural stem cells     neurogenesis    

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Technologies for Pipelining High-Pour-Point and Viscous Crudes and Their Development

Zhang Jinjun

Strategic Study of CAE 2002, Volume 4, Issue 6,   Pages 71-76

Abstract: The up-to-date research and application of technologies for pour point depression and drag reduction

Keywords： pipelining     paraffin-base crude     heavy crude     pour point depression     drag reduction     chemical additives    

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The characteristics of Paleozoic marine hydrocarbon accumulation in China

Kang Yuzhu

Strategic Study of CAE 2010, Volume 12, Issue 5,   Pages 11-17

Abstract:

In the Tarim petroleum geology investigation from 1970 to 1978, the author proposed for the first time that there was developed source rock in the Paleozoic era. A great breakthrough of Paleozoic marine hydrocarbon field was achieved in Shacan No. 2 well in 1982. Through deep research of many Paleozoic marine hydrocarbon fields, the author proposed Paleozoic marine hydrocarbon accumulation theory in 1992, which includes superposition composite basin accumulation, multi-era and multi-layer series petroleum generation, multi-stage accumulation, multi-era and multi-type reservoir-seal assemblage, multi-accumulation model and that hydrocarbon is mainly distributed around paleo-uplift, paleo-slope, fault zone and unconformity.

Keywords： Paleozoic era     marine hydrocarbon field     basin     uplift     depression     hydrocarbon distribution    

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Formation conditions of shale oil and gas in Bonan subsag, Jiyang Depression

Zhang Shanwen,Wang Yongshi,Zhang Linye,Li Zheng,Zhu Jiajun,Gong Jianqiang,Hao Yunqing

Strategic Study of CAE 2012, Volume 14, Issue 6,   Pages 49-55

Abstract: , it is concluded that the shale of Paleogene Es1, Lower Es3 and Upper Es4 in Bonan sub-sag, Jiyang Depression

Keywords： shale oil and gas     Paleogene     terrestrial shale     mineral composition     organic carbon content    

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Title Author Date Type Operation

Astrocytes in depression and Alzheimer’s disease

Journal Article

Type 2 diabetes is causally associated with depression: a Mendelian randomization analysis

Liping Xuan, Zhiyun Zhao, Xu Jia, Yanan Hou, Tiange Wang, Mian Li, Jieli Lu, Yu Xu, Yuhong Chen, Lu Qi, Weiqing Wang, Yufang Bi, Min Xu

Journal Article

Association of maternal depression with dietary intake, growth, and development of preterm infants: a

Han Wang, Hong Zhou, Yan Zhang, Yan Wang, Jing Sun

Journal Article

Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma

Journal Article

Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

Journal Article

Technologies for Pipelining High-Pour-Point and Viscous Crudes and Their Development

Zhang Jinjun

Journal Article

The characteristics of Paleozoic marine hydrocarbon accumulation in China

Kang Yuzhu

Journal Article

Formation conditions of shale oil and gas in Bonan subsag, Jiyang Depression

Zhang Shanwen,Wang Yongshi,Zhang Linye,Li Zheng,Zhu Jiajun,Gong Jianqiang,Hao Yunqing

Journal Article