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Journal Article 9

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2019 3

2014 4

2009 1

Keywords

embryonic stem cells 4

induced pluripotent stem cells 2

pluripotent stem cells 2

DNA damage 1

DNA damage repair 1

MOF 1

X-inactive specific transcript 1

bovine 1

bovine cloning 1

cardiac fibroblast 1

cardiac regeneration 1

cell cycle 1

cell proliferation 1

cell–cell communication 1

double-strand breaks (DSBs) 1

embryo 1

embryo development 1

embryonic 1

embryonic germ cells 1

gene knockout 1

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Effects of DNA damage on oocyte meiotic maturation and early embryonic development

Shen YIN,Junyu MA,Wei SHEN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3, Pages 185-190 doi: 10.15302/J-FASE-2014035

Abstract: Specially, we addressed the different effects of DNA damage on mouse oocytes and embryonic development

Keywords： DNA damage double-strand breaks (DSBs) oocyte embryo

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Factors affecting early embryonic development in cattle: relevance for bovine cloning

Yanna DANG, Kun ZHANG

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 33-41 doi: 10.15302/J-FASE-2018228

Abstract:

Female infertility represents a major challenge for improving the production efficiency in the dairy industry. Historically, fertility has declined whereas milk yield has increased tremendously due to intensive genetic selection. evidence reveals about 60% pregnancy loss takes place during the first month following fertilization. Meanwhile, early embryo development is significant for somatic cell nuclear transfer in cattle as a large proportion of cloned embryos fail to develop beyond peri-implantation stage. Oocyte quality is of utmost importance for the early embryo to develop to term for both fertilized and cloned embryos. Epigenetic reprogramming is a key process occurring after fertilization and critical roles of epigenetic modifiers during preimplantation development are now clear. Incomplete epigenetic reprogramming is believed to be a major limitation to cloning efficiency. Treatment of cloned embryos with epigenetic modifying drugs (e.g., Trichostatin A) could greatly improve cloning efficiency in both mice and cattle. Recently, the rapid progress in high-throughput sequencing technologies has enabled detailed deciphering of the molecular mechanisms underlying these events. The robust efficiency of genomic editing tools also presents an alternative approach to the functional annotation of genes critical to early development.

Keywords： bovine cloning embryo development somatic cell nuclear transfer X-inactive specific transcript

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Distinct mononuclear diploid cardiac subpopulation with minimal cell–cell communications persists in embryonic

Frontiers of Medicine Pages 939-956 doi: 10.1007/s11684-023-0987-9

Abstract: To this end, 12 645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 micefurther proved that the Myl4⁺Tnni1⁺ MNDCMs persisted in embryonic

Keywords： mononuclear diploid cardiomyocytes cell–cell communication cardiac fibroblast single-cell RNA sequencing cardiac regeneration

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Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 8-27 doi: 10.15302/J-FASE-2018233

Abstract: characterized by their capacity for high self-renewal and multiple differentiation potential and include embryonicstem cells, embryonic germ cells and induced PSCs.

Keywords： embryonic germ cells embryonic stem cells induced pluripotent stem cells pigs pluripotent stem cells

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Transcriptomics and proteomics in stem cell research

Hai Wang,Qian Zhang,Xiangdong Fang

Frontiers of Medicine 2014, Volume 8, Issue 4, Pages 433-444 doi: 10.1007/s11684-014-0336-0

Abstract:

Stem cells are capable of self-renewal and differentiation, and the processes regulating these events are among the most comprehensively investigated topics in life sciences. In particular, the molecular mechanisms of the self-renewal, proliferation, and differentiation of stem cells have been extensively examined. Multi-omics integrative analysis, such as transcriptomics combined with proteomics, is one of the most promising approaches to the systemic investigation of stem cell biology. We reviewed the available information on stem cells by examining published results using transcriptomic and proteomic characterization of the different stem cell processes. Comprehensive understanding of these important processes can only be achieved using a systemic methodology, and employing such method will strengthen the study on stem cell biology and promote the clinical applications of stem cells.

Keywords： embryonic stem cells transcriptomics proteomics

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The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 3-7 doi: 10.15302/J-FASE-2018247

Abstract:

Although the pursuit of bovine embryonic stem cells started more than 26 years ago for the purpose

Keywords： bovine embryonic induced pluripotent stem cells

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Effect of PRAK gene knockout on the proliferation of mouse embryonic fibroblasts

Xiaowei GONG MD, PhD, Xiaoyan MING MD, Xu WANG MM, Daan WANG MD, Peng DENG MM, Yong JIANG MD, PhD, Aihua LIU MD, PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4, Pages 379-383 doi: 10.1007/s11684-009-0073-y

Abstract: The growth of and mouse embryonic fibroblast (MEF) cells was measured by methylthiazoletetrazolium

Keywords： p38 regulated/activated protein kinase gene knockout cell cycle cell proliferation

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Regulation and function of histone acetyltransferase MOF

Yang Yang, Xiaofei Han, Jingyun Guan, Xiangzhi Li

Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 79-83 doi: 10.1007/s11684-014-0314-6

Abstract: We also analyze the role of MOF as a key regulator of the core transcriptional network of embryonic stem

Keywords： MOF histone acetyltransferase DNA damage repair tumorigenesis embryonic stem cells

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Progress, problems and prospects of porcine pluripotent stem cells

Hanning WANG,Yangli PEI,Ning LI,Jianyong HAN

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1, Pages 6-15 doi: 10.15302/J-FASE-2014009

Abstract: Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced PSCs (iPSCs), can differentiateThus, exploration of the unique porcine gene regulation network of preimplantation embryonic development

Keywords： induced pluripotent stem cells embryonic stem cells pig reprogramming